Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Hogenesch, W. Chan, V. Jackiw, Brownlee Rc, Yinhong Gu, M. Pray-Grant, G. Perdew, C. Bradfield (1997)Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway*
The Journal of Biological Chemistry, 272
A. Azab, Jinsong Hu, Phong Quang, F. Azab, C. Pitsillides, R. Awwad, B. Thompson, P. Maiso, Jessica Sun, C. Hart, A. Roccaro, A. Sacco, H. Ngo, Charles Lin, A. Kung, Ruben Carrasco, K. Vanderkerken, I. Ghobrial (2011)Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
Blood, 119 24
A. Chambers, A. Groom, I. Macdonald (2002)Metastasis: Dissemination and growth of cancer cells in metastatic sites
Nature Reviews Cancer, 2
CP Guise, AM Mowday, A Ashoorzadeh, R Yuan, WH Lin, DH Wu (2014)Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia
Chin J Cancer, 33
R. Bruick, S. McKnight (2001)A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
G. Comito, E. Giannoni, C. Segura, Pedro Barcellos-de-Souza, M. Raspollini, G. Baroni, M. Lanciotti, S. Serni, P. Chiarugi (2014)Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression
C. Corzo, T. Condamine, Lily Lu, M. Cotter, Je-in Youn, P. Cheng, Hyun-Il Cho, E. Celis, D. Quiceno, T. Padhya, T. Mccaffrey, J. Mccaffrey, D. Gabrilovich (2010)HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
The Journal of Experimental Medicine, 207
Hiroshi Nakamura, Y. Makino, K. Okamoto, L. Poellinger, K. Ohnuma, C. Morimoto, Hirotoshi Tanaka (2005)TCR Engagement Increases Hypoxia-Inducible Factor-1α Protein Synthesis via Rapamycin-Sensitive Pathway under Hypoxic Conditions in Human Peripheral T Cells1
The Journal of Immunology, 174
Binzhi Qian (2017)Inflammation fires up cancer metastasis.
Seminars in cancer biology, 47
A. Karnoub, A. Dash, A. Vo, Andrew Sullivan, M. Brooks, G. Bell, A. Richardson, K. Polyak, R. Tubo, R. Weinberg (2007)Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
T. Kitamura, Binzhi Qian, D. Soong, Luca Cassetta, R. Noy, Gaël Sugano, Yu Kato, Jiu-feng Li, J. Pollard (2015)CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
The Journal of Experimental Medicine, 212
A. Neesse, K. Frese, T. Bapiro, Tomoaki Nakagawa, M. Sternlicht, T. Seeley, C. Pilarsky, D. Jodrell, S. Spong, D. Tuveson (2013)CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
Proceedings of the National Academy of Sciences, 110
F. Hunter, B. Wouters, W. Wilson (2016)Hypoxia-activated prodrugs: paths forward in the era of personalised medicine
British Journal of Cancer, 114
Laura Bonapace, Marie-May Coissieux, J. Wyckoff, K. Mertz, Z. Varga, T. Junt, M. Bentires-Alj (2014)Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis
P. Chaturvedi, Daniele Gilkes, C. Wong, Kshitiz, W. Luo, Huafeng Zhang, Hong Wei, Naoharu Takano, L. Schito, A. Levchenko, G. Semenza (2013)Erratum: Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis (Journal of Clinical Investigation (2013) 123: 1 (189-205) DOI: 10.1172/JCI64993)
Journal of Clinical Investigation, 123
T. S. (1924)GROWTH
The Ulster Medical Journal, 2
Hongbo Lu, K. Kojima, V. Battula, Borys Korchin, Yue-xi Shi, Ye Chen, S. Spong, D. Thomas, H. Kantarjian, R. Lock, M. Andreeff, M. Konopleva (2014)Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth
Annals of Hematology, 93
Yongseok Choi, Song-Kyu Park, Hwan‐Mook Kim, J. Kang, Y. Yoon, S. Han, Jeung-Whan Han, Jee Yang, G. Han (2008)Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
Experimental & Molecular Medicine, 40
R. Gabitass, N. Annels, D. Stocken, H. Pandha, G. Middleton (2011)Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13
Cancer Immunology, Immunotherapy, 60
Jasdeep Saggar, I. Tannock (2014)Activity of the hypoxia‐activated pro‐drug TH‐302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy
International Journal of Cancer, 134
Fen Liu, Feiyan Ai, Li Tian, Shaojun Liu, Lian Zhao, Xiaoyan Wang (2016)Infliximab enhances the therapeutic effects of 5-fluorouracil resulting in tumor regression in colon cancer
OncoTargets and therapy, 9
C. Murdoch, A. Giannoudis, C. Lewis (2004)Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.
Blood, 104 8
Xianmin Luo, Yujie Fu, Andrew Loza, Bhavna Murali, K. Leahy, Megan Ruhland, Margery Gang, X. Su, Aliyeh Zamani, Yu Shi, K. Lavine, D. Ornitz, K. Weilbaecher, Fanxin Long, D. Novack, R. Faccio, G. Longmore, S. Stewart (2016)Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.
Cell reports, 14 1
H. Tian, S. McKnight, D. Russell (1997)Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
Genes & development, 11 1
T. Bald, T. Quast, J. Landsberg, Meri Rogava, N. Glodde, D. Lopez-Ramos, J. Kohlmeyer, S. Riesenberg, D. Boorn-Konijnenberg, Cornelia Hömig-Hölzel, R. Reuten, Benjamin Schadow, H. Weighardt, D. Wenzel, I. Helfrich, D. Schadendorf, W. Bloch, M. Bianchi, C. Lugassy, R. Barnhill, M. Koch, B. Fleischmann, I. Förster, W. Kastenmüller, W. Kolanus, M. Hölzel, E. Gaffal, T. Tüting (2014)Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
P. Chaturvedi, Daniele Gilkes, C. Wong, W. Luo, Huafeng Zhang, Hong Wei, Naoharu Takano, L. Schito, A. Levchenko, G. Semenza (2012)Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
The Journal of clinical investigation, 123 1
Q. Le, N. Denko, A. Giaccia (2004)Hypoxic gene expression and metastasis
Cancer and Metastasis Reviews, 23
S. Hung, Muh-Hwa Yang, K. Tseng, O. Lee (2013)Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression
Cell Transplantation, 22
R. Iannitti, A. Casagrande, A. Luca, C. Cunha, G. Sorci, F. Riuzzi, M. Borghi, C. Galosi, Cristina Massi-Benedetti, T. Oury, L. Cariani, M. Russo, L. Porcaro, C. Colombo, F. Majo, V. Lucidi, E. Fiscarelli, G. Ricciotti, C. Lass‐Flörl, L. Ratclif, A. Esposito, F. Benedictis, R. Donato, A. Carvalho, L. Romani (2013)Hypoxia promotes danger-mediated inflammation via receptor for advanced glycation end products in cystic fibrosis.
American journal of respiratory and critical care medicine, 188 11
D. Chan, A. Giaccia (2007)Hypoxia, gene expression, and metastasis
Cancer and Metastasis Reviews, 26
Kyeong Lee, Hwan‐Mook Kim (2011)A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor
Archives of Pharmacal Research, 34
M. Augsten (2014)Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
Frontiers in Oncology, 4
A. Doedens, C. Stockmann, M. Rubinstein, D. Liao, Na Zhang, D. DeNardo, L. Coussens, M. Karin, A. Goldrath, R. Johnson (2010)Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression.
Cancer research, 70 19
T. Zhao, H. Ren, L. Jia, Jing Chen, Wen Xin, Fan Yan, Jing Li, Xiuchao Wang, Song Gao, D. Qian, Chongbiao Huang, J. Hao (2014)Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
E. Giannoni, F. Bianchini, L. Calorini, P. Chiarugi (2011)Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness.
Antioxidants & redox signaling, 14 12
E. Campbell, W. Bruyninckx, Caleb Kelly, L. Glover, E. McNamee, Brittelle Bowers, A. Bayless, M. Scully, B. Saeedi, L. Golden‐Mason, S. Ehrentraut, V. Curtis, Adrianne Burgess, J. Garvey, Amber Sorensen, R. Nemenoff, P. Jedlicka, C. Taylor, D. Kominsky, S. Colgan (2014)Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation.
Immunity, 40 1
A. Ikejiri, S. Nagai, N. Goda, Y. Kurebayashi, Mayuko Osada-Oka, K. Takubo, T. Suda, S. Koyasu (2012)Dynamic regulation of Th17 differentiation by oxygen concentrations.
International immunology, 24 3
Tina Rayes, R. Catena, Sharrell Lee, Marcin Stawowczyk, N. Joshi, C. Fischbach, C. Powell, A. Dannenberg, N. Altorki, Dingcheng Gao, V. Mittal (2015)Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1
Proceedings of the National Academy of Sciences, 112
C. Murdoch, M. Muthana, C. Lewis (2005)Hypoxia Regulates Macrophage Functions in Inflammation1
The Journal of Immunology, 175
M. Noman, G. Desantis, B. Janji, M. Hasmim, S. Karray, P. Dessen, V. Bronte, S. Chouaib (2014)PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
The Journal of Experimental Medicine, 211
Sheridan Hoy (2017)Pomalidomide: A Review in Relapsed and Refractory Multiple Myeloma
S. Tohme, H. Yazdani, A. Al-Khafaji, A. Chidi, P. Loughran, K. Mowen, Yanming Wang, R. Simmons, Hai Huang, A. Tsung (2016)Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress.
Cancer research, 76 6
BZ Olenyuk, G-J Zhang, JM Klco, NG Nickols, WG Kaelin, PB Dervan (2004)Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
Proc Natl Acad Sci U S A, 101
T. Nagasaki, M. Hara, Hayao Nakanishi, Hiroki Takahashi, Mikinori Sato, H. Takeyama (2013)Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction
British Journal of Cancer, 110
Victoria Liu, Larry Wong, T. Jang, Ali Shah, I. Park, Ximing Yang, Qiang Zhang, S. Lonning, B. Teicher, Chung Lee (2007)Tumor Evasion of the Immune System by Converting CD4+CD25− T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-β
The Journal of Immunology, 178
C. Tripathi, B. Tewari, R. Kanchan, K. Baghel, Naveen Nautiyal, R. Shrivastava, Harbeer Kaur, M. Bhatt, S. Bhadauria (2014)Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin
Honor Hugo, C. Saunders, R. Ramsay, E. Thompson (2015)New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis
Journal of Mammary Gland Biology and Neoplasia, 20
Yaozhong Hu, Jing Liu, He-sheng Huang (2013)Recent agents targeting HIF‐1α for cancer therapy
Journal of Cellular Biochemistry, 114
Long-yun Ye, Wei Chen, X. Bai, Xingyuan Xu, Qi Zhang, X. Xia, Xu Sun, Guogang Li, Qi-da Hu, Q. Fu, T. Liang (2016)Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis.
Cancer research, 76 4
E. Francesco, R. Lappano, M. Santolla, S. Marsico, A. Caruso, M. Maggiolini (2013)HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs)
Breast Cancer Research : BCR, 15
T. Condamine, I. Ramachandran, Je-in Youn, D. Gabrilovich (2015)Regulation of tumor metastasis by myeloid-derived suppressor cells.
Annual review of medicine, 66
T. Cramer, Y. Yamanishi, B. Clausen, I. Förster, R. Pawlinski, N. Mackman, V. Haase, R. Jaenisch, M. Corr, V. Nizet, G. Firestein, H. Gerber, N. Ferrara, R. Johnson (2003)HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
GL Wang, BH Jiang, EA Rue, GL Semenza (1995)Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
Proc Natl Acad Sci U S A, 92
Elena Sierra-Filardi, Concha Nieto, Ángeles Domínguez-Soto, Ruben Barroso, P. Sánchez-Mateos, A. Puig-Kroger, María López-Bravo, J. Joven, Carlos Ardavín, J. Rodríguez-Fernández, C. Sánchez-Torres, M. Mellado, Á. Corbí (2014)CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile
The Journal of Immunology, 192
Candace Carroll, Yayun Liang, Indira Benakanakere, C. Besch-Williford, S. Hyder (2012)The anticancer agent YC-1 suppresses progestin-stimulated VEGF in breast cancer cells and arrests breast tumor development
International Journal of Oncology, 42
Elizabeth Finger, Chao Cheng, T. Williams, E. Rankin, B. Bedogni, L. Tachiki, S. Spong, A. Giaccia, Marianne Powell (2014)CTGF is a therapeutic target for metastatic melanoma
B. Mann, John Johnson, M. Cohen, R. Justice, R. Pazdur (2007)FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.
The oncologist, 12 10
Jonathan Mitchem, D. Brennan, Brett Knolhoff, B. Belt, Yu Zhu, D. Sanford, Larisa Belaygorod, D. Carpenter, Lynne Collins, D. Piwnica-Worms, S. Hewitt, G. Udupi, W. Gallagher, C. Wegner, B. West, A. Wang-Gillam, P. Goedegebuure, D. Linehan, D. DeNardo (2013)Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.
Cancer research, 73 3
Laura D'Ignazio, D. Bandarra, S. Rocha (2015)NF‐κB and HIF crosstalk in immune responses
The Febs Journal, 283
M. Höckel, C. Knoop, K. Schlenger, B. Vorndran, Evmarie Bauβnann, M. Mitze, P. Knapstein, P. Vaupel (1993)Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 26 1
Selma Pennacchietti, P. Michieli, M. Galluzzo, M. Mazzone, S. Giordano, P. Comoglio (2003)Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.
Cancer cell, 3 4
Author Affiliations, C. Guise, A. Mowday, Amir Ashoorzadeh, Ran Yuan, Wan-Hua Lin, Dong-hai Wu, J. Smaill, A. Patterson, K. DingChinese Journal of Cancer
Wenyang Pang, N. Lou, C. Jin, Changyuan Hu, Chandoo Arvine, Guangbao Zhu, Xian Shen (2016)Combination of preoperative platelet/lymphocyte and neutrophil/lymphocyte rates and tumor-related factors to predict lymph node metastasis in patients with gastric cancer
European Journal of Gastroenterology & Hepatology, 28
H. Dvorak (1986)Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
The New England journal of medicine, 315 26
Yu Zheng, Dennis Basel, Shu-Oi Chow, Colette Fong-Yee, Sarah Kim, F. Buttgereit, C. Dunstan, Hong Zhou, M. Seibel (2014)Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone
Clinical & Experimental Metastasis, 31
Guifu Wu, Arjuna Mannam, Jiaping Wu, Simona Kirbiš, J. Shie, Christopher Chen, R. Laham, F. Sellke, Jian Li (2003)Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF.
American journal of physiology. Heart and circulatory physiology, 285 6
S. Chawla, L. Cranmer, B. Tine, D. Reed, S. Okuno, J. Butrynski, D. Adkins, A. Hendifar, S. Kroll, K. Ganjoo (2014)Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32 29
M. Hansen, B. Forst, Natascha Cremers, L. Quagliata, N. Ambartsumian, Birgitte Grum-Schwensen, J. Klingelhöfer, A. Abdul-Al, P. Herrmann, M. Osterland, U. Stein, G. Nielsen, P. Scherer, Lukanidin Em, J. Sleeman, M. Grigorian (2014)A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4
J. Rice, J. Veal, P. Fadden, A. Barabasz, Jeffrey Partridge, T. Barta, Laura Dubois, K. Huang, S. Mabbett, M. Silinski, P. Steed, S. Hall (2008)Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
Arthritis and rheumatism, 58 12
L. Greenberger, I. Horak, D. Filpula, P. Sapra, M. Westergaard, H. Frydenlund, Charlotte Albæk, H. Schrøder, H. Ørum (2008)A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth
Molecular Cancer Therapeutics, 7
J. Yeh, William Kim (2015)Targeting tumor hypoxia with hypoxia-activated prodrugs.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33 13
D. Palmieri, P. Lockman, Fancy Thomas, Emily Hua, J. Herring, Elizabeth Hargrave, Matthew Johnson, N. Flores, Yongzhen Qian, Eleazar Vega-Valle, Kunal Taskar, Vinay Rudraraju, R. Mittapalli, Julie Gaasch, K. Bohn, H. Thorsheim, D. Liewehr, S. Davis, J. Reilly, R. Walker, J. Bronder, L. Feigenbaum, S. Steinberg, K. Camphausen, P. Meltzer, V. Richon, Q. Smith, P. Steeg (2009)Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks
Clinical Cancer Research, 15
Bo Huang, Z. Lei, Jie Zhao, W. Gong, Jinwen Liu, Zhen-zhen Chen, Yi Liu, Dong Li, Ye Yuan, Gui-mei Zhang, Zuo-hua Feng (2007)CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers.
Cancer letters, 252 1
Rui Zhang, Xuejiao Song, Chao Liang, Xuan Yi, Guosheng Song, Y. Chao, Yu Yang, Kai Yang, Liangzhu Feng, Zhuang Liu (2017)Catalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancer.
Damya Laoui, Eva Overmeire, G. Conza, Chiara Aldeni, J. Keirsse, Yannick Morias, K. Movahedi, Isabelle Houbracken, E. Schouppe, Y. Elkrim, O. Karroum, B. Jordan, P. Carmeliet, C. Gysemans, P. Baetselier, M. Mazzone, J. Ginderachter (2014)Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.
Cancer research, 74 1
P. Maxwell, M. Wiesener, G. Chang, S. Clifford, E. Vaux, M. Cockman, C. Wykoff, C. Pugh, E. Maher, P. Ratcliffe (1999)The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Robert D'Amato, Suzanne Lentzsch, K. Anderson, Michael Rogers (2001)Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma.
Seminars in oncology, 28 6
Liwen Chen, E. Tredget, P. Wu, Yaojiong Wu (2008)Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing
PLoS ONE, 3
M. Höckel, K. Schlenger, Billur Aral, M. Mitze, U. Schäffer, P. Vaupel (1996)Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.
Cancer research, 56 19
J. Klune, R. Dhupar, Jon Cardinal, T. Billiar, A. Tsung (2008)HMGB1: Endogenous Danger Signaling
Molecular Medicine, 14
Guang-lan Wang, G. Semenza (1995)Purification and Characterization of Hypoxia-inducible Factor 1 (*)
The Journal of Biological Chemistry, 270
Guang-lei Wang, B. Jiang, E. Rue, G. Semenza (1995)Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Proceedings of the National Academy of Sciences of the United States of America, 92 12
H. Semba, Norihiko Takeda, T. Isagawa, Y. Sugiura, Kurara Honda, Masaki Wake, Hidenobu Miyazawa, Y. Yamaguchi, M. Miura, Dana Jenkins, Hyunsung Choi, Jung-whan Kim, M. Asagiri, A. Cowburn, Hajime Abe, K. Soma, K. Koyama, Manami Katoh, Keimon Sayama, N. Goda, R. Johnson, I. Manabe, R. Nagai, I. Komuro (2016)HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Nature Communications, 7
M. Ohh, Cheol Park, Cheol Park, M. Ivan, M. Hoffman, Tae-You Kim, Tae-You Kim, L. Huang, N. Pavletich, N. Pavletich, V. Chau, W. Kaelin, W. Kaelin (2000)Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
Nature Cell Biology, 2
G. Semenza (2003)Targeting HIF-1 for cancer therapy
Nature Reviews Cancer, 3
Y Choi, S-K Park, HM Kim, JS Kang, YD Yoon, SB Han (2008)Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp. Mol
H. Ban, Yoshikazu Uto, M. Won, Hiroyuki Nakamura (2016)Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)
Expert Opinion on Therapeutic Patents, 26
Yao-Ting Huang, S. Pan, J. Guh, Ya-Ling Chang, F. Lee, S. Kuo, C. Teng (2005)YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells
Molecular Cancer Therapeutics, 4
David Chiu, I. Xu, R. Lai, Aki Tse, Larry Wei, Hui-Yu Koh, Lynna Li, Derek Lee, R. Lo, Chun‐Ming Wong, I. Ng, C. Wong (2016)Hypoxia induces myeloid‐derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C‐C motif) ligand 26
Daiki Eguchi, Naoki Ikenaga, K. Ohuchida, S. Kozono, Lin Cui, K. Fujiwara, M. Fujino, T. Ohtsuka, K. Mizumoto, Masao Tanaka (2013)Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor.
The Journal of surgical research, 181 2
A. Kai, L. Chan, R. Lo, J. Lee, C. Wong, J. Wong, I. Ng (2016)Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma
Hepatology (Baltimore, Md.), 64
M Ema, S Taya, N Yokotani, K Sogawa, Y Matsuda, Y Fujii-Kuriyama (1997)A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1 regulates the VEGF expression and is potentially involved in lung and vascular development
Proc Natl Acad Sci U S A, 94
Daniele Gilkes, S. Bajpai, P. Chaturvedi, D. Wirtz, G. Semenza (2013)Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts*
The Journal of Biological Chemistry, 288
E. Petrangeli, G. Coroniti, A. Brini, L. Girolamo, D. Stanco, S. Niada, G. Silecchia, E. Morgante, C. Lubrano, M. Russo, L. Salvatori (2016)Hypoxia Promotes the Inflammatory Response and Stemness Features in Visceral Fat Stem Cells From Obese Subjects
Journal of Cellular Physiology, 231
A. Casazza, Damya Laoui, M. Wenes, S. Rizzolio, Nicklas Bassani, M. Mambretti, S. Deschoemaeker, J. Ginderachter, L. Tamagnone, M. Mazzone (2013)Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.
Cancer cell, 24 6
M. Tamm, M. Bihl, O. Eickelberg, P. Stulz, A. Perruchoud, M. Roth (1998)Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells.
American journal of respiratory cell and molecular biology, 19 4
L. Hawinkels, M. Paauwe, H. Verspaget, E. Wiercinska, J. Zon, K. Ploeg, P Koelink, J Lindeman, W. Mesker, P. Dijke, C Sier (2014)Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts
吉田 茂生 (1999)Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis
W. Jeong, A. Rapisarda, Sook Park, R. Kinders, A. Chen, G. Melillo, B. Turkbey, S. Steinberg, P. Choyke, J. Doroshow, S. Kummar (2014)Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
Cancer Chemotherapy and Pharmacology, 73
Vasilios Liapis, A. Zysk, M. DeNichilo, Irene Zinonos, S. Hay, V. Panagopoulos, Alexandra Shoubridge, Christopher Difelice, V. Ponomarev, W. Ingman, G. Atkins, D. Findlay, A. Zannettino, A. Evdokiou (2017)Anticancer efficacy of the hypoxia‐activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma
Cancer Medicine, 6
A. Nevler, E. Shabtai, M. Gutman, M. Shabtai (2014)The effects of hormonal replacement therapy (HRT) on mammographic breast density and abnormal mammograms prompting further investigation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32 26_suppl
P. Voorhees, R. Manges, P. Sonneveld, S. Jagannath, G. Somlo, A. Krishnan, S. Lentzsch, R. Frank, S. Zweegman, P. Wijermans, R. Orlowski, B. Kranenburg, B. Hall, T. Casneuf, X. Qin, H. Velde, H. Xie, Sheeba Thomas (2013)A phase 2 multicentre study of siltuximab, an anti‐interleukin‐6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
British Journal of Haematology, 161
Qingmin Fan, Ying-ying Jing, Guo-feng Yu, Xing-rui Kou, Fei Ye, Lu Gao, Rong Li, Qiu-dong Zhao, Yang Yang, Zheng-hua Lu, Li-xin Wei (2014)Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma.
Cancer letters, 352 2
Hasini Jayatilaka, Pranay Tyle, Jonathan Chen, Minsuk Kwak, Julia Ju, Hyun Kim, Jerry Lee, Pei-Hsun Wu, Daniele Gilkes, R. Fan, D. Wirtz (2017)Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration
Nature Communications, 8
R. Sullivan, Geneviève Paré, Lisa Frederiksen, G. Semenza, C. Graham (2008)Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity
Molecular Cancer Therapeutics, 7
AF Chambers, AC Groom, IC MacDonald (2002)Dissemination and growth of cancer cells in metastatic sites
Nat Rev Cancer, 2
Balraj Singh, Jacob Berry, A. Shoher, A. Shoher, G. Ayers, G. Ayers, Caimiao Wei, Anthony Lucci (2007)COX-2 involvement in breast cancer metastasis to bone
M. Tsujii, S. Kawano, R. Dubois (1997)Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential.
Proceedings of the National Academy of Sciences of the United States of America, 94 7
B. Wei, Minya Yao, Chunyang Xing, W. Wang, Jianyun Yao, Y. Hong, Yu Liu, Peifen Fu (2016)The neutrophil lymphocyte ratio is associated with breast cancer prognosis: an updated systematic review and meta-analysis
OncoTargets and therapy, 9
A. Epstein, J. Gleadle, L. McNeill, K. Hewitson, J. O'rourke, D. Mole, Mridul Mukherji, E. Metzen, Michael Wilson, A. Dhanda, Ya-min Tian, N. Masson, D. Hamilton, P. Jaakkola, R. Barstead, J. Hodgkin, P. Maxwell, C. Pugh, C. Schofield, P. Ratcliffe (2001)C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
F. Leoni, G. Fossati, E. Lewis, Jae-Kwon Lee, G. Porro, P. Pagani, D. Modena, M. Moras, P. Pozzi, L. Reznikov, B. Siegmund, G. Fantuzzi, C. Dinarello, P. Mascagni (2005)The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo
Molecular Medicine, 11
G. Semenzato (2003)TARGETING HIF-1 FOR CANCER THERAPY
D. Hanahan, R. Weinberg (2011)Hallmarks of Cancer: The Next Generation
N. Kundu, A. Fulton (2002)Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer.
Cancer research, 62 8
P. Munster, K. Thurn, Scott Thomas, P. Raha, M. Lacevic, Ashleigh Miller, M. Melisko, R. Ismail-Khan, H. Rugo, M. Moasser, S. Minton (2011)A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
British Journal of Cancer, 104
G. Semenza (2009)Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
M. Mimeault, S. Batra (2013)Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
Journal of Cellular and Molecular Medicine, 17
H. Nesbitt, Niall Byrne, Niall Byrne, Nicole Williams, L. Ming, J. Worthington, R. Errington, L. Patterson, Paul Smith, S. Mckeown, D. McKenna (2016)Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression
Clinical Cancer Research, 23
Lei Xu, K. Xie, N. Mukaida, K. Matsushima, I. Fidler (1999)Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer research, 59 22
N. Rohwer, T. Cramer (2011)Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 14 3
Wenchao Zhou, Susan Ke, Zhi Huang, William Flavahan, X. Fang, J. Paul, Ling Wu, A. Sloan, R. McLendon, Xiaoxia Li, J. Rich, S. Bao (2014)Periostin Secreted by Glioblastoma Stem Cells Recruits M2 Tumor-associated Macrophages and Promotes Malignant Growth
Nature cell biology, 17
Li Yang, Yi Zhang (2017)Tumor-associated macrophages: from basic research to clinical application
Journal of Hematology & Oncology, 10
Xiaomeng Zhang, Jonathan Wojtkowiak, G. Martinez, H. Cornnell, C. Hart, A. Baker, R. Gillies (2016)MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts
PLoS ONE, 11
S. Yoshida, M. Ono, T. Shono, H. Izumi, T. Ishibashi, Hideo Suzuki, M. Kuwano (1997)Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis
Molecular and Cellular Biology, 17
R. Snodgrass, Marcel Boss, E. Zezina, A. Weigert, N. Dehne, I. Fleming, B. Brüne, D. Namgaladze (2015)Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages*
The Journal of Biological Chemistry, 291
S. Ha, So-Young Yeo, Yan-hiua Xuan, Seok-Hyung Kim (2014)The Prognostic Significance of Cancer-Associated Fibroblasts in Esophageal Squamous Cell Carcinoma
PLoS ONE, 9
B. Bao, Aamir Ahmad, D. Kong, Shadan Ali, A. Azmi, Yiwei Li, Sanjeev Banerjee, S. Padhye, F. Sarkar (2012)Hypoxia Induced Aggressiveness of Prostate Cancer Cells Is Linked with Deregulated Expression of VEGF, IL-6 and miRNAs That Are Attenuated by CDF
PLoS ONE, 7
G. Semenza (2000)HIF-1: mediator of physiological and pathophysiological responses to hypoxia.
Journal of applied physiology, 88 4
Xin Lu, Yibin Kang (2010)Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis
Clinical Cancer Research, 16
Y. Tamura, T. Torigoe, G. Kutomi, K. Hirata, N. Sato (2012)New paradigm for intrinsic function of heat shock proteins as endogenous ligands in inflammation and innate immunity.
Current molecular medicine, 12 9
Kota Wakiyama, Y. Kitajima, Tomokazu Tanaka, M. Kaneki, K. Yanagihara, S. Aishima, Jun Nakamura, H. Noshiro (2017)Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis
Scientific Reports, 7
Hang Chang, K. Shyu, Bao-wei Wang, P. Kuan (2003)Regulation of hypoxia-inducible factor-1alpha by cyclical mechanical stretch in rat vascular smooth muscle cells.
Clinical science, 105 4
D. Hutt, D. Roth, H. Vignaud, C. Cullin, M. Bouchecareilh (2014)The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition
PLoS ONE, 9
A. Loboda, A. Józkowicz, J. Dulak (2010)HIF-1 and HIF-2 transcription factors — Similar but not identical
Molecules and Cells, 29
Daniele Gilkes, G. Semenza (2013)Role of hypoxia-inducible factors in breast cancer metastasis.
Future oncology, 9 11
V. Falanga, S. Qian, D. Danielpour, M. Katz, A. Roberts, M. Sporn (1991)Hypoxia upregulates the synthesis of tgf-β1 by human dermal fibroblasts
Journal of Investigative Dermatology, 97
D. Marvel, D. Gabrilovich (2015)Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected.
The Journal of clinical investigation, 125 9
F Leoni, A Zaliani, G Bertolini, G Porro, P Pagani, P Pozzi (2002)The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
Proc Natl Acad Sci U S A, 99
L. Shi, Ruoning Wang, Gonghua Huang, P. Vogel, G. Neale, D. Green, H. Chi (2011)HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
The Journal of Experimental Medicine, 208
S. Chouaib, S. Chouaib, M. Noman, M. Noman, K. Kosmatopoulos, M. Curran (2017)Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
A Neesse, KK Frese, TE Bapiro, T Nakagawa, MD Sternlicht, TW Seeley (2013)CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
Proc Natl Acad Sci U S A, 110
T Rayes, R Catena, S Lee, M Stawowczyk, N Joshi, C Fischbach (2015)Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1
Proc Natl Acad Sci U S A, 112
Y. Yu, C. Xiao, Li-Duan Tan, Q.S. Wang, X-Q Li, Yu-mei Feng (2013)Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
British Journal of Cancer, 110
Li Yang, Jianhua Huang, X. Ren, Agnieszka Gorska, A. Chytil, M. Aakre, D. Carbone, L. Matrisian, A. Richmond, P. Lin, H. Moses (2008)Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
Cancer cell, 13 1
Hyun‐Ja Jeong, Seung-Heon Hong, R. Park, T. Shin, N. An, Hyung‐Min Kim (2005)Hypoxia-induced IL-6 production is associated with activation of MAP kinase, HIF-1, and NF-κB on HEI-OC1 cells
Hearing Research, 207
Xinhai Wan, Zhi-gang Li, J. Yingling, Jun Yang, M. Starbuck, M. Ravoori, V. Kundra, E. Vazquez, N. Navone (2012)Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth.
Bone, 50 3
M. Krieg, R. Haas, H. Brauch, T. Acker, I. Flamme, K. Plate (2000)Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
Caroline Wigerup, S. Påhlman, D. Bexell (2016)Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer.
Pharmacology & therapeutics, 164
Theerawut Chanmee, Pawared Ontong, Ken-ichi Konno, N. Itano (2014)Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment
Daniele Gilkes, G. Semenza, D. Wirtz (2014)Hypoxia and the extracellular matrix: drivers of tumour metastasis
Nature Reviews Cancer, 14
Shicheng Su, Qiang Liu, Jingqi Chen, Jianing Chen, Fei Chen, Chonghua He, Di Huang, Wei Wu, Ling Lin, Wei Huang, Jin Zhang, X. Cui, Fang Zheng, Haiyan Li, H. Yao, F. Su, E. Song (2014)A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
Cancer cell, 25 5
K. Jhaveri, S. Modi (2015)Ganetespib: research and clinical development
OncoTargets and therapy, 8
Huafeng Zhang, Huafeng Zhang, C. Wong, Hong Wei, Daniele Gilkes, P. Korangath, P. Chaturvedi, L. Schito, L. Schito, Jasper Chen, B. Krishnamachary, P. Winnard, V. Raman, L. Zhen, W. Mitzner, S. Sukumar, G. Semenza (2011)HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs
N. Bhola, J. Balko, T. Dugger, M. Kuba, V. Sanchez, M. Sanders, Jamie Stanford, R. Cook, C. Arteaga (2013)TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer.
The Journal of clinical investigation, 123 3
Wen-fang Chen, Haley Hill, A. Christie, M. Kim, E. Holloman, Andrea Pavía-Jiménez, Farrah Homayoun, Yuanqing Ma, Nirav Patel, Paul Yell, G. Hao, Qurratulain Yousuf, Allison Joyce, I. Pedrosa, Heather Geiger, He Zhang, Jenny Chang, K. Gardner, R. Bruick, C. Reeves, Tae Hwang, K. Courtney, E. Frenkel, Xiankai Sun, N. Zojwalla, T. Wong, Jim Rizzi, E. Wallace, J. Josey, Yang Xie, Xian-Jin Xie, Payal Kapur, R. McKay, J. Brugarolas (2016)Targeting renal cell carcinoma with a HIF-2 antagonist
S. Kondo, S. Kubota, T. Shimo, T. Nishida, Gen Yosimichi, T. Eguchi, T. Sugahara, M. Takigawa (2002)Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.
Carcinogenesis, 23 5
C. Kudo-Saito, Hiromi Shirako, T. Takeuchi, Y. Kawakami (2009)Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
Cancer cell, 15 3
J. Mojsilovic-Petrovic, D. Callaghan, H. Cui, Clare Dean, D. Stanimirovic, Wandong Zhang (2007)Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes
Journal of Neuroinflammation, 4
K. Ganjoo, L. Cranmer, J. Butrynski, D. Rushing, D. Adkins, S. Okuno, G. Lorente, S. Kroll, V. Langmuir, S. Chawla (2011)A Phase I Study of the Safety and Pharmacokinetics of the Hypoxia-Activated Prodrug TH-302 in Combination with Doxorubicin in Patients with Advanced Soft Tissue Sarcoma
E. Wallace, Jim Rizzi, Guangzhou Han, Paul Wehn, Z. Cao, Xinlin Du, Tzuling Cheng, R. Czerwinski, Darryl Dixon, Barry Goggin, J. Grina, Megan Halfmann, Melissa Maddie, Sarah Olive, S. Schlachter, Huiling Tan, Bin Wang, Keshi Wang, S. Xie, Rui Xu, Hanbiao Yang, J. Josey (2016)A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Cancer research, 76 18
Debangshu Samanta, Daniele Gilkes, P. Chaturvedi, Lisha Xiang, G. Semenza (2014)Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
Proceedings of the National Academy of Sciences, 111
Antje Egners, M. Erdem, T. Cramer (2016)The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases
Mediators of Inflammation, 2016
Natalia Baran, M. Konopleva (2017)Molecular Pathways: Hypoxia-Activated Prodrugs in Cancer Therapy
Clinical Cancer Research, 23
M Tsujii, S Kawano, RN DuBois (1997)Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
Proc Natl Acad Sci U S A, 94
Daniele Gilkes (2016)Implications of Hypoxia in Breast Cancer Metastasis to Bone
International Journal of Molecular Sciences, 17
M Ammirante, S Shalapour, Y Kang, CAM Jamieson, M Karin (2014)Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts
Proc Natl Acad Sci U S A, 111
M. Ema, S. Taya, N. Yokotani, K. Sogawa, Youichi Matsuda, Y. Fujii‐Kuriyama (1997)A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.
Proceedings of the National Academy of Sciences of the United States of America, 94 9
Luciana Schwab, D. Peacock, Debeshi Majumdar, J. Ingels, Laura Jensen, Keisha Smith, Richard Cushing, T. Seagroves (2012)Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
Breast Cancer Research : BCR, 14
E. Rofstad, Heidi Rasmussen, Kanthi Galappathi, B. Mathiesen, K. Nilsen, B. Graff (2002)Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.
Cancer research, 62 6
Ngoc Hoang, Tetsuya Kadonosono, T. Kuchimaru, S. Kizaka-Kondoh (2016)Hypoxia‐inducible factor‐targeting prodrug TOP3 combined with gemcitabine or TS‐1 improves pancreatic cancer survival in an orthotopic model
Cancer Science, 107
S. Pan, J. Guh, Chieh-Yu Peng, Ya-Ling Chang, Fong-Chi Cheng, Jau-Hsiang Chang, S. Kuo, F. Lee, C. Teng (2005)A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models
Thrombosis and Haemostasis, 93
Shanthini Crusz, F. Balkwill (2015)Inflammation and cancer: advances and new agents
Nature Reviews Clinical Oncology, 12
N. Obermajer, Ravikumar Muthuswamy, K. Odunsi, R. Edwards, P. Kalinski (2011)PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment.
Cancer research, 71 24
P. Mehlen, A. Puisieux (2006)Metastasis: a question of life or death
Nature Reviews Cancer, 6
Leilei Tao, Shu-Jing Shi, Long-Bang Chen, Guichun Huang (2014)Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia.
World journal of gastroenterology, 20 15
Sadashib Ghosh, Arkoprovo Paul, E. Sen (2013)Tumor Necrosis Factor Alpha-Induced Hypoxia-Inducible Factor 1α–β-Catenin Axis Regulates Major Histocompatibility Complex Class I Gene Activation through Chromatin Remodeling
Molecular and Cellular Biology, 33
F. Leoni, A. Zaliani, G. Bertolini, G. Porro, P. Pagani, P. Pozzi, G. Dona, G. Fossati, S. Sozzani, T. Azam, P. Bufler, G. Fantuzzi, I. Goncharov, Soohyun Kim, B. Pomerantz, L. Reznikov, B. Siegmund, C. Dinarello, P. Mascagni (2002)The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
Proceedings of the National Academy of Sciences of the United States of America, 99
Lisha Xiang, Daniele Gilkes, P. Chaturvedi, W. Luo, Hongxia Hu, Naoharu Takano, Houjie Liang, G. Semenza (2014)Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer
Journal of Molecular Medicine, 92
E. Dang, J. Barbi, Huang-Yu Yang, Dilini Jinasena, Hong-gang Yu, Ying Zheng, Zachary Bordman, Juan Fu, Y. Kim, Hung-Rong Yen, W. Luo, K. Zeller, L. Shimoda, S. Topalian, G. Semenza, C. Dang, D. Pardoll, F. Pan (2011)Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
P Chaturvedi, DM Gilkes, N Takano, GL Semenza (2014)Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
Proc Natl Acad Sci U S A, 111
I. Almendros, Yang Wang, L. Becker, Frances Lennon, Jiamao Zheng, Brittney Coats, Kelly Schoenfelt, A. Carreras, F. Hakim, Shelley Zhang, R. Farré, D. Gozal (2014)Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea.
American journal of respiratory and critical care medicine, 189 5
Junjie Xu, Longbo Zheng, Jiang Chen, Yin Sun, Hui Lin, Ren’an Jin, M. Tang, X. Liang, Xiujun Cai (2017)Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals
Cell Death & Disease, 8
E. Guida, Alastair Stewart (1998)Influence of Hypoxia and Glucose Deprivation on Tumour Necrosis Factor-Alpha and Granulocyte- Macrophage Colony-Stimulating Factor Expression in Human Cultured Monocytes
Cellular Physiology and Biochemistry, 8
Xiaoming Li, H. Shepard, J. Cowell, Chunmei Zhao, R. Osgood, S. Rosengren, B. Blouw, S. Garrovillo, M. Pagel, Clifford Whatcott, Haiyong Han, D. Hoff, D. Taverna, M. LaBarre, D. Maneval, Curtis Thompson (2018)Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression
Clinical Cancer Research, 24
Binzhi Qian, Jiu-feng Li, Hui Zhang, T. Kitamura, Jinghang Zhang, Liam Campion, E. Kaiser, L. Snyder, J. Pollard (2011)CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Meng-Yu Wu, Giuo-Teng Yiang, P. Cheng, P. Chu, Chia-Jung Li (2018)Molecular Targets in Hepatocarcinogenesis and Implications for Therapy
Journal of Clinical Medicine, 7
G. Semenza (2001)HIF-1 and mechanisms of hypoxia sensing.
Current opinion in cell biology, 13 2
T. Shimo, S. Kubota, S. Kondo, T. Nakanishi, Akira Sasaki, H. Mese, T. Matsumura, M. Takigawa (2001)Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line.
Cancer letters, 174 1
Jagdeep Singh, Bruno Simões, S. Howell, G. Farnie, R. Clarke (2013)Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Breast Cancer Research : BCR, 15
P. Vaupel, A. Mayer, M. Höckel (2009)Tumor hypoxia and malignant progression.
Methods in enzymology, 381
D Samanta, DM Gilkes, P Chaturvedi, L Xiang, GL Semenza (2014)Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
Proc Natl Acad Sci U S A, 111
S. Kondo, S. Kubota, Y. Mukudai, Norifumi Moritani, T. Nishida, H. Matsushita, S. Matsumoto, T. Sugahara, M. Takigawa (2006)Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3′-untranslated region interacting with a cellular protein in human chondrosarcoma cells
V. Picozzi, J. Pipas, A. Koong, A. Giaccia, N. Bahary, S. Krishnamurthi, C. Lopez, P. O'dwyer, K. Modelska, Mairead Carney, H. Hernandez, J. Chou, Tyson Lee, M. Zhong, Seth Porter, T. Neff, F. Valone (2014)FG-3019, a human monoclonal antibody to connective tissue growth factor (CTGF), with gemcitabine/erlotinib (G/E) in patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).
Journal of Clinical Oncology, 32
A. Deisseroth, C. Ko, L. Nie, J. Zirkelbach, Liang Zhao, J. Bullock, N. Mehrotra, P. Valle, H. Saber, Christopher Sheth, Brenda Gehrke, R. Justice, A. Farrell, R. Pazdur (2015)FDA Approval: Siltuximab for the Treatment of Patients with Multicentric Castleman Disease
Clinical Cancer Research, 21
N. Klempt, E. Sirimanne, A. Gunn, M. Klempt, K. Singh, C. Williams, P. Gluckman (1992)Hypoxia-ischemia induces transforming growth factor beta 1 mRNA in the infant rat brain.
Brain research. Molecular brain research, 13 1-2
P. Koivunen, Stuart Fell, Wenyun Lu, J. Rabinowitz, A. Kung, S. Schlisio (2016)The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth
D. Thomas, P. Radhakrishnan (2019)Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis
Molecular Cancer, 18
Yingming Zhu, Yuanwei Zang, F. Zhao, Zhenxiang Li, Jianbo Zhang, Liang Fang, Minghuan Li, L. Xing, Zhonghua Xu, Jinming Yu (2017)Inhibition of HIF-1α by PX-478 suppresses tumor growth of esophageal squamous cell cancer in vitro and in vivo.
American journal of cancer research, 7 5
Keunhee Oh, Ok-Young Lee, Suh-Youn Shon, Onyou Nam, Po Ryu, M. Seo, Dong-Sup Lee (2013)A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model
Breast Cancer Research : BCR, 15
B. Olenyuk, Guo‐Jun Zhang, J. Klco, N. Nickols, W. Kaelin, P. Dervan (2004)Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist.
Proceedings of the National Academy of Sciences of the United States of America, 101 48
Lei Chen, Yingbin Xu, Jingling Zhao, Zhaoqiang Zhang, Ronghua Yang, Julin Xie, Xusheng Liu, S. Qi (2014)Conditioned Medium from Hypoxic Bone Marrow-Derived Mesenchymal Stem Cells Enhances Wound Healing in Mice
PLoS ONE, 9
D. Stiehl, W. Jelkmann, R. Wenger, T. Hellwig-Bürgel (2002)Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway
FEBS Letters, 512
Yu Zheng, Shu-Oi Chow, K. Boernert, Dennis Basel, A. Mikuscheva, Sarah Kim, Colette Fong-Yee, T. Trivedi, F. Buttgereit, R. Sutherland, C. Dunstan, Hong Zhou, M. Seibel (2014)Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto‐Amplification of IL‐6 and RANKL Signaling Pathways
Journal of Bone and Mineral Research, 29
Debangshu Samanta, Youngrok Park, S. Andrabi, Laura Shelton, Daniele Gilkes, G. Semenza (2016)PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
Cancer research, 76 15
J. Miguel, K. Weisel, P. Moreau, M. Lacy, K. Song, M. Delforge, L. Karlin, H. Goldschmidt, A. Banos, A. Oriol, A. Alegre, Christine Chen, M. Cavo, L. Garderet, V. Ivanova, J. Martínez-López, A. Belch, A. Palumbo, S. Schey, P. Sonneveld, Xin Yu, L. Sternås, C. Jacques, M. Zaki, M. Dimopoulos (2013)Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial.
The Lancet. Oncology, 14 11
G. Semenza, Guang-lei Wang (1992)A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Molecular and Cellular Biology, 12
K. Sun, Nils Halberg, Mahmood Khan, U. Magalang, P. Scherer (2012)Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
Molecular and Cellular Biology, 33
I. Lohse, Joanna Rasowski, P. Cao, M. Pintilie, Trevor Do, M. Tsao, R. Hill, D. Hedley (2016)Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
A. Lilja, C. Weeden, K. McArthur, T. Nguyen, A. Donald, Z. Wong, Lovisa Dousha, S. Bozinovski, R. Vlahos, C. Burns, M. Asselin-Labat, G. Anderson (2015)HSP90 Inhibition Suppresses Lipopolysaccharide-Induced Lung Inflammation In Vivo
PLoS ONE, 10
M. Ammirante, S. Shalapour, Youngjin Kang, C. Jamieson, M. Karin (2014)Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts
Proceedings of the National Academy of Sciences, 111
H. Nesbitt, J. Worthington, R. Errington, L. Patterson, Paul Smith, S. Mckeown, D. McKenna (2017)The unidirectional hypoxia‐activated prodrug OCT1002 inhibits growth and vascular development in castrate‐resistant prostate tumors
The Prostate, 77
S. Wculek, I. Malanchi (2015)Neutrophils support lung colonization of metastasis-initiating breast cancer cells
S. Chafe, Y. Lou, Jaclyn Sceneay, M. Vallejo, M. Hamilton, P. McDonald, K. Bennewith, A. Möller, S. Dedhar (2015)Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.
Cancer research, 75 6
Lihui Wang, Guoliang Chen, Xiuhong Lu, Shuang Wang, S. Han, Yi Li, Guanfang Ping, Xiaorui Jiang, Huahuan Li, Jingyu Yang, Chunfu Wu (2015)Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: synthesis, anti-invasive and anti-angiogenic properties.
European journal of medicinal chemistry, 89
D. Pardoll (2012)The blockade of immune checkpoints in cancer immunotherapy
Nature Reviews Cancer, 12
長﨑 高也 (2014)Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis : anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour-stroma interaction
Christine Hudson, Mei Liu, G. Chiang, D. Otterness, Dawn Loomis, F. Kaper, A. Giaccia, R. Abraham (2002)Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
Molecular and Cellular Biology, 22
A. Kaidi, D. Qualtrough, A. Williams, C. Paraskeva (2006)Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
Cancer research, 66 13
Julia Ju, I. Godet, I. Ye, J. Byun, Hasini Jayatilaka, S. Lee, Lisha Xiang, Debangshu Samanta, Meng-Horng Lee, Pei-Hsun Wu, D. Wirtz, G. Semenza, Daniele Gilkes (2017)Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis
Molecular Cancer Research, 15
P. Chaturvedi, Daniele Gilkes, Naoharu Takano, G. Semenza (2014)Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
Proceedings of the National Academy of Sciences, 111
Metastasis is the leading cause of cancer-related deaths. Recent research has implicated tumor inflammation as a promoter of metastasis. Myeloid, lymphoid, and mesenchymal cells in the tumor microenvironment promote inflammatory signaling amongst each other and together with cancer cells to modulate sustained inflammation, which may enhance cancer invasiveness. Tumor hypoxia, a state of reduced available oxygen present in the majority of solid tumors, acts as a prognostic factor for a worse outcome and is known to have a role in tumor inflammation through the regulation of inflammatory mediator signals in both cancer and neighboring cells in the microenvironment. Multiple methods to target tumor hypoxia have been developed and tested in clinical trials, and still more are emerging as the impacts of hypoxia become better understood. These strategies include mechanistic inhibition of the hypoxia inducible factor signaling pathway and hypoxia activated pro-drugs, leading to both anti-tumor and anti-inflammatory effects. This prompts a need for further research on the prevention of hypoxia-mediated inflammation in cancer. Hypoxia-targeting strategies seem to have the most potential for therapeutic benefit when combined with traditional chemotherapy agents. This paper will serve to summarize the role of the inflammatory response in metastasis, to discuss how hypoxia can enable or enhance inflammatory signaling, and to review established and emerging strategies to target the hypoxia-inflammation-metastasis axis.
Targeted Oncology – Springer Journals
Published: Feb 8, 2018
Access the full text.
Sign up today, get DeepDyve free for 14 days.