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Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons Tumour necrosis factor (TNF) and lymphotoxin were initially described as tumoricidal proteins that are produced by activated macrophages1,2 and lymphocytes3,4, respectively. Since TNF and lymphotoxin are structurally related, bind to the same cell surface receptor5 and have indistinguishable biological activities6,7, they have been designated as TNF-α and TNF-β, respectively8. The multiple activities8–15 of these molecules indicate their importance in immunoregulative responses. Here we report that both TNF-α and TNF-β have antiviral activity and synergize with interferons (IFNs) in the induction of resistance to both RNA and DNA virus infection in diverse cell types. These effects of TNFs are not due to the induction of IFN synthesis. Virus-infected cells are selectively killed by TNFs and this activity is accelerated by IFN-γ. The production of TNFs is induced by viruses, further suggesting the importance of TNFs in the physiological antiviral response. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

Nature , Volume 323 (6091) – Oct 30, 1986

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References (37)

Publisher
Springer Journals
Copyright
Copyright © Nature Publishing Group 1986
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/323819a0
Publisher site
See Article on Publisher Site

Abstract

Tumour necrosis factor (TNF) and lymphotoxin were initially described as tumoricidal proteins that are produced by activated macrophages1,2 and lymphocytes3,4, respectively. Since TNF and lymphotoxin are structurally related, bind to the same cell surface receptor5 and have indistinguishable biological activities6,7, they have been designated as TNF-α and TNF-β, respectively8. The multiple activities8–15 of these molecules indicate their importance in immunoregulative responses. Here we report that both TNF-α and TNF-β have antiviral activity and synergize with interferons (IFNs) in the induction of resistance to both RNA and DNA virus infection in diverse cell types. These effects of TNFs are not due to the induction of IFN synthesis. Virus-infected cells are selectively killed by TNFs and this activity is accelerated by IFN-γ. The production of TNFs is induced by viruses, further suggesting the importance of TNFs in the physiological antiviral response.

Journal

NatureSpringer Journals

Published: Oct 30, 1986

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