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Type distribution of human papillomavirus in HIV-infected women with cervical intraepithelial neoplasia (CIN) stages 2 and 3 in Botswana

Type distribution of human papillomavirus in HIV-infected women with cervical intraepithelial... Ramogola-Masire et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A83 http://www.infectagentscancer.com/content/5/S1/A83 MEETING ABSTRACTS Open Access Type distribution of human papillomavirus in HIV- infected women with cervical intraepithelial neoplasia (CIN) stages 2 and 3 in Botswana 1,2* 1,2 2 2 2 Doreen Ramogola-Masire , Nicola M Zetola , Veronica de Klerk , Barati Monare , Bakgaki Ratshaa , 2 2 2 3 1 Gracious Ditlhabang , Elisabeth Chibaya , Metlha Nchunga , Mukendi K Kayembe , Kurt T Barnhart , 1 1,2 Cindy M McGrath , Harvey M Friedman th From 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 26-27 April, 2010 Background Results Human papillomavirus (HPV) vaccines containing This is an interim analysis of an intended sample size types 16 and 18 are remarkably effective in preventing of 100 women. We identified 30 HIV-infected women cervical cancer associated with these HPV types. No with CIN stages 2 or 3 between August 11, 2009, and information currently exists in Botswana concerning January 29, 2010. The median age was 36 (interquartile the HPV types causing precancerous or cancerous range [IQR], 33 - 38) and the median CD4 cell count 3 3 lesions. was 427 cells/mm (IQR, 360-560 cells/mm ). Of the 30 women enrolled, 28 (93%) had co-infection by mul- Methods tiple HPV types. HPV type 52 was found in the 2 (7%) The goal of this pilot project was to determine the HPV women carrying a single type. 15 (50%) had HPV types types causing precancerous cervical intraepithelial neo- 16, 18, or both. 25 (83%) women, including all the plasia (CIN) stages 2 and 3 in HIV-infected women in ones not carrying the 16 or 18 types, carried other Gaborone, Botswana. HIV-infected women referred to high-risk HPV types. Among the other high-risk types, our clinic with high-grade intraepithelial lesion (HSIL) HPV types 33, 35, and 58 were the most prevalent, on the Pap smear were enrolled in the study. Two speci- accounting for 7 (23%), 8 (27%), and 10 (33%) cases, mens were obtained on all subjects, one for histopathol- respectively. ogy and the other for HPV typing. HPV typing was performed only if the histopathology results demon- Conclusion strated CIN stage 2 or 3 disease. Histopathology results HPV 16 and 18 are the most common types in HIV- were corroborated at two sites: Lancet Laboratories infected women with CIN 2 or 3 in Gaborone, Bots- (Johannesburg, South Africa) and University of Pennsyl- wana. However, other high-risk HPV types may vania (Pennsylvania, United States). HPV typing was account for a significant number of advanced CIN performed using linear arraygenotyping(CE-IVD, lesions in this population. Roche Diagnostics). Acknowledgements This article has been published as part of Infectious Agents and Cancer th Volume 5 Supplement 1, 2010: Proceedings of the 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1. *Correspondence: doreen.masire@gmail.com Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA Full list of author information is available at the end of the article © 2010 Ramogola-Masire et al; licensee BioMed Central Ltd. Ramogola-Masire et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A83 Page 2 of 2 http://www.infectagentscancer.com/content/5/S1/A83 Author details Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2 3 Botswana-UPenn Partnership, Gaborone, Botswana. National Health Laboratory, Gaborone, Botswana. Published: 11 October 2010 doi:10.1186/1750-9378-5-S1-A83 Cite this article as: Ramogola-Masire et al.: Type distribution of human papillomavirus in HIV-infected women with cervical intraepithelial neoplasia (CIN) stages 2 and 3 in Botswana. Infectious Agents and Cancer 2010 5(Suppl 1):A83. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infectious Agents and Cancer Springer Journals

Type distribution of human papillomavirus in HIV-infected women with cervical intraepithelial neoplasia (CIN) stages 2 and 3 in Botswana

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Publisher
Springer Journals
Copyright
Copyright © 2010 by Ramogola-Masire et al; licensee BioMed Central Ltd.
Subject
Biomedicine; Cancer Research; Infectious Diseases; Oncology
eISSN
1750-9378
DOI
10.1186/1750-9378-5-S1-A83
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Abstract

Ramogola-Masire et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A83 http://www.infectagentscancer.com/content/5/S1/A83 MEETING ABSTRACTS Open Access Type distribution of human papillomavirus in HIV- infected women with cervical intraepithelial neoplasia (CIN) stages 2 and 3 in Botswana 1,2* 1,2 2 2 2 Doreen Ramogola-Masire , Nicola M Zetola , Veronica de Klerk , Barati Monare , Bakgaki Ratshaa , 2 2 2 3 1 Gracious Ditlhabang , Elisabeth Chibaya , Metlha Nchunga , Mukendi K Kayembe , Kurt T Barnhart , 1 1,2 Cindy M McGrath , Harvey M Friedman th From 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI) Bethesda, MD, USA. 26-27 April, 2010 Background Results Human papillomavirus (HPV) vaccines containing This is an interim analysis of an intended sample size types 16 and 18 are remarkably effective in preventing of 100 women. We identified 30 HIV-infected women cervical cancer associated with these HPV types. No with CIN stages 2 or 3 between August 11, 2009, and information currently exists in Botswana concerning January 29, 2010. The median age was 36 (interquartile the HPV types causing precancerous or cancerous range [IQR], 33 - 38) and the median CD4 cell count 3 3 lesions. was 427 cells/mm (IQR, 360-560 cells/mm ). Of the 30 women enrolled, 28 (93%) had co-infection by mul- Methods tiple HPV types. HPV type 52 was found in the 2 (7%) The goal of this pilot project was to determine the HPV women carrying a single type. 15 (50%) had HPV types types causing precancerous cervical intraepithelial neo- 16, 18, or both. 25 (83%) women, including all the plasia (CIN) stages 2 and 3 in HIV-infected women in ones not carrying the 16 or 18 types, carried other Gaborone, Botswana. HIV-infected women referred to high-risk HPV types. Among the other high-risk types, our clinic with high-grade intraepithelial lesion (HSIL) HPV types 33, 35, and 58 were the most prevalent, on the Pap smear were enrolled in the study. Two speci- accounting for 7 (23%), 8 (27%), and 10 (33%) cases, mens were obtained on all subjects, one for histopathol- respectively. ogy and the other for HPV typing. HPV typing was performed only if the histopathology results demon- Conclusion strated CIN stage 2 or 3 disease. Histopathology results HPV 16 and 18 are the most common types in HIV- were corroborated at two sites: Lancet Laboratories infected women with CIN 2 or 3 in Gaborone, Bots- (Johannesburg, South Africa) and University of Pennsyl- wana. However, other high-risk HPV types may vania (Pennsylvania, United States). HPV typing was account for a significant number of advanced CIN performed using linear arraygenotyping(CE-IVD, lesions in this population. Roche Diagnostics). Acknowledgements This article has been published as part of Infectious Agents and Cancer th Volume 5 Supplement 1, 2010: Proceedings of the 12 International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI). The full contents of the supplement are available online at http://www.biomedcentral.com/1750-9378/5?issue=S1. *Correspondence: doreen.masire@gmail.com Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA Full list of author information is available at the end of the article © 2010 Ramogola-Masire et al; licensee BioMed Central Ltd. Ramogola-Masire et al. Infectious Agents and Cancer 2010, 5(Suppl 1):A83 Page 2 of 2 http://www.infectagentscancer.com/content/5/S1/A83 Author details Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 2 3 Botswana-UPenn Partnership, Gaborone, Botswana. National Health Laboratory, Gaborone, Botswana. Published: 11 October 2010 doi:10.1186/1750-9378-5-S1-A83 Cite this article as: Ramogola-Masire et al.: Type distribution of human papillomavirus in HIV-infected women with cervical intraepithelial neoplasia (CIN) stages 2 and 3 in Botswana. Infectious Agents and Cancer 2010 5(Suppl 1):A83. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit

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Infectious Agents and Cancer – Springer Journals

Published: Oct 11, 2010

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