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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal growth factor receptor (EGFR) in response to BRAF inhibition. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

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References (27)

Publisher
Springer Journals
Copyright
Copyright © 2012 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/nature10868
Publisher site
See Article on Publisher Site

Abstract

Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal growth factor receptor (EGFR) in response to BRAF inhibition.

Journal

NatureSpringer Journals

Published: Jan 26, 2012

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