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Virgin Coconut Oil (VCO) Ameliorates High Fat Diet (HFD)-Induced Obesity, Dyslipidemia and Bestows Cardiovascular Protection in Rats

Virgin Coconut Oil (VCO) Ameliorates High Fat Diet (HFD)-Induced Obesity, Dyslipidemia and... Effects of hot process-derived virgin coconut oil (VCO) on antiobesity, lipid-lowering and cardio-protection in male Wistar rat models fed with high-fat diet (HFD) were investigated for 7 weeks. The marked increase in body weight, liver weight, epididymal fat weight, and specific growth rate of HFD-fed rats were significantly attenuated when the HFD was supplemented with VCO. Serum lipid profile of VCO-fed rats showed significantly reduced levels of triglycerides, total cholesterol, low and very low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), and increment in high-density lipoprotein cholesterol (HDL-C) level. Significant decrease in cardiac risk indices and CHOLINDEX in all the VCO-treated animal groups were observed. Hepatic enzymatic biomarkers associated with HFD-induced liver damage were reversed with the VCO supplementation. Thus, dose-dependent VCO supplementation can be considered as an effective dietary approach to attenuate obesity and to alleviate the risks of cardiovascular diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Proceedings of the National Academy of Sciences, India Section B:Biological Sciences" Springer Journals

Virgin Coconut Oil (VCO) Ameliorates High Fat Diet (HFD)-Induced Obesity, Dyslipidemia and Bestows Cardiovascular Protection in Rats

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References (32)

Publisher
Springer Journals
Copyright
Copyright © The National Academy of Sciences, India 2022
ISSN
0369-8211
eISSN
2250-1746
DOI
10.1007/s40011-021-01318-y
Publisher site
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Abstract

Effects of hot process-derived virgin coconut oil (VCO) on antiobesity, lipid-lowering and cardio-protection in male Wistar rat models fed with high-fat diet (HFD) were investigated for 7 weeks. The marked increase in body weight, liver weight, epididymal fat weight, and specific growth rate of HFD-fed rats were significantly attenuated when the HFD was supplemented with VCO. Serum lipid profile of VCO-fed rats showed significantly reduced levels of triglycerides, total cholesterol, low and very low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), and increment in high-density lipoprotein cholesterol (HDL-C) level. Significant decrease in cardiac risk indices and CHOLINDEX in all the VCO-treated animal groups were observed. Hepatic enzymatic biomarkers associated with HFD-induced liver damage were reversed with the VCO supplementation. Thus, dose-dependent VCO supplementation can be considered as an effective dietary approach to attenuate obesity and to alleviate the risks of cardiovascular diseases.

Journal

"Proceedings of the National Academy of Sciences, India Section B:Biological Sciences" – Springer Journals

Published: Jun 1, 2022

Keywords: Virgin coconut oil; Anti-obesity; Cardio-protectant effect; High-fat diet; Hypolipidemia; Hepatosteatosis

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