Access the full text.
Sign up today, get DeepDyve free for 14 days.
(2001)Chapter 16. Urease
I. Konieczna, P. Żarnowiec, M. Kwinkowski, B. Kolesińska, J. Frączyk, Z. Kaminski, W. Kaca (2012)Bacterial Urease and its Role in Long-Lasting Human Diseases
Current Protein & Peptide Science, 13
L. Prasad, T. Khan, T. Jahangir, S. Sultana (2006)Effect of gallic acid on renal biochemical alterations in male Wistar rats induced by ferric nitriloacetic acid
Human and Experimental Toxicology, 25
B. Krajewska (2009)Ureases I. Functional, catalytic and kinetic properties: A review
Journal of Molecular Catalysis B-enzymatic, 59
(2019)Antifungal and antileishmanial activities of fractions and Emeka E
Ghias Uddina, Ismaila, Abdur Raufa, Muslim Razaa, Haroon Khanb, Nasruddina, Majid Khanc, Umar Farooqd, Ajmal Khand, Abdul Khan (2016)Urease inhibitory profile of extracts and chemical constituents of Pistacia atlantica ssp. cabulica Stocks
Natural Product Research, 30
Wakawa Yusufu, F. Ahmad, Z. Ahmad (2017)Antibacterial activity of leaves and root extracts of Abrus precatorius
Journal of Medicinal Plants Studies, 5
Uroko Ikechukwu, Sangodare Adeyi, M. Hadiza, A. Lilian (2015)Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)
Journal of Biological Sciences, 15
(2010)Biochemical effects of aqueous leaf extract of Abrus precatorius (Jecquirity bean) in Swiss albino mice
(2016)Diversity of medicinal plants in Pt
A. Balasubramanian, K. Ponnuraj (2010)Crystal structure of the first plant urease from jack bean: 83 years of journey from its first crystal to molecular structure.
Journal of molecular biology, 400 3
Farrukh Mansoor, I. Anis, Ajmal Khan, B. Marasini, M. Choudhary, M. Shah (2014)Urease inhibitory constituents from Daphne retusa
Journal of Asian Natural Products Research, 16
Yixiong Chen, J. Liao, Min Chen, Qiaoyin Huang, Qiming Lu (2015)Gossypol : New class of urease inhibitors , molecular docking and inhibition assay
(2016)Diversity of medicinal plants in Pt. Ravishankar Shukla University campus, Raipur, Chhattisgarh, India
(2008)Insights into the role and structure of plant ureases. Phytochemistry
E. Okoro, M. Ahmad, O. Osoniyi, F. Onajobi (2019)Antifungal and antileishmanial activities of fractions and isolated isoflavanquinones from the roots of Abrus precatorius
Comparative Clinical Pathology, 29
S. Kuo, Sheng-Chih Chen, Lin Chen, Jin-Bin Wu, Jih Wang, C. Teng (1995)Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius.
Planta medica, 61 4
E. Okoro, O. Osoniyi, A. Jabeen, Sidrah Shams, M. Choudhary, F. Onajobi (2019)Anti-proliferative and immunomodulatory activities of fractions from methanol root extract of Abrus precatorius L
Clinical Phytoscience, 5
O. Adelowotan, I. Aibinu, E. Adenipekun, Tolu Odugbemi (2008)The in-vitro antimicrobial activity of Abrus precatorius (L) fabaceae extract on some clinical pathogens.
The Nigerian postgraduate medical journal, 15 1
J. Klastersky, M. Aoun (2004)Opportunistic infections in patients with cancer.
Annals of oncology : official journal of the European Society for Medical Oncology, 15 Suppl 4
B. Umamahesh, C. Veeresham (2016)Antihyperglycemic and Insulin Secretagogue Activities of Abrus precatorius Leaf Extract
Pharmacognosy Research, 8
T. Halgren (1996)Merck molecular force field. I. Basis, form, scope, parameterization, and performance of MMFF94
Journal of Computational Chemistry, 17
Song Chun (1998)ABRUQUINONE A,B,D,E,F AND G FROM THE ROOT OF ABRUS PRECATORIUS
Acta Botanica Sinica
K. Chinsembu (2016)Ethnobotanical Study of Plants Used in the Management of HIV/AIDS-Related Diseases in Livingstone, Southern Province, Zambia
Evidence-based Complementary and Alternative Medicine : eCAM, 2016
L. Modolo, Aline Souza, Lívia Horta, D. Araujo, Â. Fátima (2014)An overview on the potential of natural products as ureases inhibitors: A review
Journal of Advanced Research, 6
C. Reynolds (2015)Ligand efficiency metrics: why all the fuss?
Future medicinal chemistry, 7 11
A. Coates, Gerry Halls, Yanmin Hu (2011)Novel classes of antibiotics or more of the same?
British Journal of Pharmacology, 163
Vandana Janghel, P. Patel, S. Chandel (2019)Plants used for the treatment of icterus (jaundice) in Central India: A review.
Annals of hepatology
M. LÃƒÂ©bri, M. Tilaoui, C. Bahi, H. Achibat, S. Akhramez, Y. FofiÃƒÂ, G. GnahouÃƒÂ, S. Lagou, G. Zirihi, A. Coulibaly, A. Zyad, A. Hafid, M. Khouili (2015)Phytochemical analysis and in vitro anticancer effect of aqueous extract of Abrus precatorius Linn
S. Benini, W. Rypniewski, K. Wilson, S. Miletti, S. Ciurli, S. Mangani (2000)The complex of Bacillus pasteurii urease with acetohydroxamate anion from X-ray data at 1.55 Å resolution
JBIC Journal of Biological Inorganic Chemistry, 5
C. Follmer (2008)Insights into the role and structure of plant ureases.
Phytochemistry, 69 1
S. Gafner, C. Bergeron, Jacquelyn Villinski, M. Godejohann, P. Kessler, J. Cardellina, D. Ferreira, K. Feghali, D. Grenier (2011)Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification.
Journal of natural products, 74 12
A. Lupi, F. Monache, G. Marini-Bettolo, D. Costa, I.Leoncio d'Albuquerque (1979)ABRUQUINONES: NEW NATURAL ISOFLAVANQUINONES
S. Al-Nasiry, N. Geusens, M. Hanssens, C. Luyten, R. Pijnenborg (2007)The use of Alamar Blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells.
Human reproduction, 22 5
E. Okoro, Rukesh Maharjan, A. Jabeen, M. Ahmad, M. Azhar, Nuzhat Shehla, Wajid Zaman, Sidrah Shams, O. Osoniyi, F. Onajobi, M. Choudhary (2021)Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects.
Yixi Xie, Weijie Yang, Fen Tang, Xiaoqing Chen, L. Ren (2014)Antibacterial activities of flavonoids: structure-activity relationship and mechanism.
Current medicinal chemistry, 22 1
(2021)Isoflavanquinones from Abrus precatorius roots with their antiproliferative and antiinflammatory effects. Phytochemistry
D. Mora, S. Arioli (2014)Microbial Urease in Health and Disease
PLoS Pathogens, 10
福田能啓, ほか (2003)Helicobacter pylori 除菌の問題点
(2010)Determination of Antibacterial Activity of MIC of Crude Extract of Abrus precatorius L
Shreyasi Palit, S. Kar, G. Sharma, P. Das (2015)Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway
Journal of Cellular Physiology, 230
F. Farhadi, B. Khameneh, M. Iranshahi, Milad Iranshahy (2018)Antibacterial activity of flavonoids and their structure–activity relationship: An update review
Phytotherapy Research, 33
A. Gnanamani, P. Hariharan, M. Paul-Satyaseela (2017)Staphylococcus aureus: Overview of Bacteriology, Clinical Diseases, Epidemiology, Antibiotic Resistance and Therapeutic Approach
T. Mosmann (1983)Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
Journal of immunological methods, 65 1-2
S. Sarker, L. Nahar, Y. Kumarasamy (2007)Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals
Methods (San Diego, Calif.), 42
A. Adamczak, M. Ożarowski, T. Karpiński (2019)Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants
Journal of Clinical Medicine, 9
P. Kafarski, M. Talma (2018)Recent advances in design of new urease inhibitors: A review
Journal of Advanced Research, 13
(2006)The effects of gallic acid on renal biochemical alterations in male rats
M. Orita, K. Ohno, Masaichi Warizaya, Y. Amano, T. Niimi (2011)Lead generation and examples opinion regarding how to follow up hits.
Methods in enzymology, 493
E. Pettersen, Thomas Goddard, Conrad Huang, Gregory Couch, Daniel Greenblatt, E. Meng, T. Ferrin (2004)UCSF Chimera—A visualization system for exploratory research and analysis
Journal of Computational Chemistry, 25
Sherif Hassan, Miroslava Šudomová (2017)The Development of Urease Inhibitors: What Opportunities Exist for Better Treatment of Helicobacter pylori Infection in Children?
Vangelis Economou, Panagiota Gousia, A. Kansouzidou, H. Sakkas, P. Karanis, C. Papadopoulou (2013)Prevalence, antimicrobial resistance and relation to indicator and pathogenic microorganisms of Salmonella enterica isolated from surface waters within an agricultural landscape.
International journal of hygiene and environmental health, 216 4
Divyashree Ravishankar, A. Rajora, F. Greco, H. Osborn (2013)Flavonoids as prospective compounds for anti-cancer therapy.
The international journal of biochemistry & cell biology, 45 12
C. Reynolds, S. Bembenek, B. Tounge (2007)The role of molecular size in ligand efficiency.
Bioorganic & medicinal chemistry letters, 17 15
A. Shenoy, B. Varghese, M. Rajan, S. Koshy (2012)ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF ABRUS PRECATORIUS LEAVES
E. Boix (2010)Assessment of antimicrobial compounds by microscopy techniques
Sebastian Salentin, Sven Schreiber, V. Haupt, Melissa Adasme, M. Schroeder (2015)PLIP: fully automated protein–ligand interaction profiler
Nucleic Acids Research, 43
D. Hanahan, R. Weinberg (2011)Hallmarks of Cancer: The Next Generation
Abstract Phytochemical studies of methanol soluble fractions of Abrus precatorius Linn (Fabaceae) led to the isolation of four abruquinones (abruquinones M, A, E, and B). Structures of the compounds were elucidated using spectroscopic analyses - 1D, 2D NMR, HRESI-MS. Evaluation of the therapeutic effects of A. precatorius fractions showed significant (p < 0.05) antibacterial and antiurease activities. Further therapeutic evaluation of the compounds showed that abruquinones M, A, E, and B demonstrated antibacterial activities by inhibiting significantly (p < 0.05) the growth of multidrug resistant S. aureus (MIC values ranged from 20 - 30 μg/mL) (µM) via induction of morphological damages with concomitant membrane segmentation. Abruquinones A and B showed significant (p < 0.05) urease inhibiting activity (IC50 values 35.2 and 37.7 µM, respectively), docked tightly to the side chains of urease enzyme active site via π-cation interactions, as well as showed cytotoxicity against AU565 and MDA-MB231 breast cancer cells (IC50 values 23.13 and 9.05 μM, respectively). These findings suggest abruquinones (isoflavanquinones) from A. precatorius roots as viable candidates for further mechanistic studies on possible antibacterial, antiurease, and anticancer drug development.
Journal of Biologically Active Products from Nature – Taylor & Francis
Published: May 4, 2022
Keywords: Abrus precatorius; Abruquinone; Antibacterial; Antiurease; Breast cancer
Access the full text.
Sign up today, get DeepDyve free for 14 days.