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Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of Mesua borneensis L.

Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of Mesua... AbstractThe aim of this study was to assess the antimalarial and antioxidant effects of the n-hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1),mammea A/ AA cyclo D (2) and mesuol (3) from the stem bark of M. borneensis L. The n-hexane and ethyl acetate extracts, as well as compounds 1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging. Compound 2 exhibited slightly more active than chloroquine. Compounds 1 and 3 showed very high activity against DPPH radical. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biologically Active Products from Nature Taylor & Francis

Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of Mesua borneensis L.

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Publisher
Taylor & Francis
Copyright
© 2016 Har Krishan Bhalla & Sons
ISSN
2231-1874
eISSN
2231-1866
DOI
10.1080/22311866.2016.1188726
Publisher site
See Article on Publisher Site

Abstract

AbstractThe aim of this study was to assess the antimalarial and antioxidant effects of the n-hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1),mammea A/ AA cyclo D (2) and mesuol (3) from the stem bark of M. borneensis L. The n-hexane and ethyl acetate extracts, as well as compounds 1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging. Compound 2 exhibited slightly more active than chloroquine. Compounds 1 and 3 showed very high activity against DPPH radical.

Journal

Journal of Biologically Active Products from Nature – Taylor & Francis

Published: Mar 3, 2016

Keywords: Isoprenylated coumarin; Mesua borneensis L; Antimalarial; Antioxidant

References

  • In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L.seed oil
  • 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase
  • Daphnifolin, a new xanthone from Mesua daphnifolia
  • Pyranoxan- thones from Messua ferrea
  • 4-Alkyl and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials
  • Antiplasmodial activity of triterpenoid isolated from thr whole plants of Viola genus from South Korea
  • Antiplasmodial and other conctituents from four Garcinia spp
  • Antioxidant and cytotoxic agent from the rhizomes of Kaempferia pandurata
  • Chemical composition and antioxidant of Algerian Juniperus phoeniceae L
  • The systematic identification of organic compounds
  • In vitro antiplasmodial, antiamoebic and cytotoxic activities of a series of bisbenylisoquinoline alkaloids