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Automated determination of an angiotensin ii receptor antagonist, cgp 48 933, in plasma by high-performance liquid chromatography

Automated determination of an angiotensin ii receptor antagonist, cgp 48 933, in plasma by... Abstract A fully automated high-performance liquid chromatography method with fluorimetric detection is described for the determination of CGP 48 933 in human plasma. Liquid-solid extraction was performed automatically on C8 reversed phase column using the Gilson ASPEC system. The on-line chromatography was performed on a ODS Hypersil C18 5 μm column. The mobile phase, acetonitrile- pH 2.8 phosphate buffer (50:50, v/v) was used at a flow rate of 1.3 ml/min. The fluorimetric excitation and emission wavelengths were set at 265 and 378 nm, respectively. The limit of quantitation of CGP 48 933 was 11.5 nmol per litre of plasma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Liquid Chromatography Taylor & Francis

Automated determination of an angiotensin ii receptor antagonist, cgp 48 933, in plasma by high-performance liquid chromatography

Automated determination of an angiotensin ii receptor antagonist, cgp 48 933, in plasma by high-performance liquid chromatography

Journal of Liquid Chromatography , Volume 17 (10): 8 – Jun 1, 1994

Abstract

Abstract A fully automated high-performance liquid chromatography method with fluorimetric detection is described for the determination of CGP 48 933 in human plasma. Liquid-solid extraction was performed automatically on C8 reversed phase column using the Gilson ASPEC system. The on-line chromatography was performed on a ODS Hypersil C18 5 μm column. The mobile phase, acetonitrile- pH 2.8 phosphate buffer (50:50, v/v) was used at a flow rate of 1.3 ml/min. The fluorimetric excitation and emission wavelengths were set at 265 and 378 nm, respectively. The limit of quantitation of CGP 48 933 was 11.5 nmol per litre of plasma.

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References (2)

Publisher
Taylor & Francis
Copyright
Copyright Taylor & Francis Group, LLC
ISSN
0148-3919
DOI
10.1080/10826079408013539
Publisher site
See Article on Publisher Site

Abstract

Abstract A fully automated high-performance liquid chromatography method with fluorimetric detection is described for the determination of CGP 48 933 in human plasma. Liquid-solid extraction was performed automatically on C8 reversed phase column using the Gilson ASPEC system. The on-line chromatography was performed on a ODS Hypersil C18 5 μm column. The mobile phase, acetonitrile- pH 2.8 phosphate buffer (50:50, v/v) was used at a flow rate of 1.3 ml/min. The fluorimetric excitation and emission wavelengths were set at 265 and 378 nm, respectively. The limit of quantitation of CGP 48 933 was 11.5 nmol per litre of plasma.

Journal

Journal of Liquid ChromatographyTaylor & Francis

Published: Jun 1, 1994

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