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Different Spectrophotometric Methods Applied for the Determination of Aclidinium in Duaklir ® Genuair ® Inhalation Powder

Different Spectrophotometric Methods Applied for the Determination of Aclidinium in Duaklir ®... AbstractThree simple, accurate and selective spectrophotometric methods were developed to determine aclidinium in the presence of formoterol as interferent compound in Duaklir ® Genuair ® inhalation powder. The methods under study are absorbance subtraction, area under the curve and simultaneous equation. The methods were linear over the concentration range of 5-50 μg/mL for aclidinium and validated according to the ICH guidelines. The accuracy and precision were found to be within the acceptable limits. The specificity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. Furthermore, the methods were statistically compared to the RP-HPLC method and good results were obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Different Spectrophotometric Methods Applied for the Determination of Aclidinium in Duaklir ® Genuair ® Inhalation Powder

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Different Spectrophotometric Methods Applied for the Determination of Aclidinium in Duaklir ® Genuair ® Inhalation Powder

Abstract

AbstractThree simple, accurate and selective spectrophotometric methods were developed to determine aclidinium in the presence of formoterol as interferent compound in Duaklir ® Genuair ® inhalation powder. The methods under study are absorbance subtraction, area under the curve and simultaneous equation. The methods were linear over the concentration range of 5-50 μg/mL for aclidinium and validated according to the ICH guidelines. The accuracy and precision were found to be within...
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Publisher
Taylor & Francis
Copyright
© 2018 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2018.1467278
Publisher site
See Article on Publisher Site

Abstract

AbstractThree simple, accurate and selective spectrophotometric methods were developed to determine aclidinium in the presence of formoterol as interferent compound in Duaklir ® Genuair ® inhalation powder. The methods under study are absorbance subtraction, area under the curve and simultaneous equation. The methods were linear over the concentration range of 5-50 μg/mL for aclidinium and validated according to the ICH guidelines. The accuracy and precision were found to be within the acceptable limits. The specificity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. Furthermore, the methods were statistically compared to the RP-HPLC method and good results were obtained.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Jul 4, 2018

Keywords: Aclidinium; formoterol; absorbance subtraction; simultaneous equation; area under the curve

References

  • Aclidinium Bromide Inhalation Powder (Tudorza): A Long-Acting Anticholinergic for the Management Of Chronic Obstructive Pulmonary Disease
  • Electrochemical Behavior of Formoterol Fumarate and Its Determination in Capsules for Inhalation and Human Serum using Differential Pulse and Square Wave Voltammetry
  • Quantitative determination of the β-adrenoceptor stimulant formoterol in urine by gas chromatography mass spectrometry
  • Development and validation of spectro-photometric methods for estimation of formoterol bulk drug and its pharmaceutical dosage forms
  • Validated stability indicating derivative and derivative ratio methods for the determination of some drugs used to alleviate respiratory tract disorders and their degradation products
  • Forced degradation of mometasone furoate and development of two RP-HPLC methods for its determination with formoterol fumarate or salicylic acid
  • High performance liquid chromatography assay method for simultaneous quantitation of formoterol and budesonide in Symbicort Turbuhaler
  • Sensitive and Robust Methods for Simultaneous Determination of Beclomethasone Dipropionate and Formoterol Fumarate Dihydrate in Rotacaps
  • A validated TLC-densitometric method for the simultaneous determination of formoterol fumarate and budesonide in pressurized metered-dose inhaler
  • Validated chromato-graphic methods for the simultaneous determination of Mometasone furoate and Formoterol fuma-rate dihydrate in a combined dosage form
  • Simultaneous RP-HPLC Method for determination of impurities in Formoterol Fumarate and Aclidinium Bromide in Pharmaceutical Dosage Forms
  • Different spectrophotometric methods applied for the analysis of simeprevir in the presence of its oxidative degradation product: A comparative study
  • Stability indicating methods for the analysis of cefprozil in the presence of its alkaline induced degradation product
  • Firefly algorithm versus genetic algorithm as powerful variable selection tools and their effect on different multivariate calibration models in spectroscopy: A comparative study
  • Different spectrophotometric methods applied for the analysis of binary mixture of flucloxacillin and amoxicillin: A comparative study
  • Absorbance subtraction and amplitude modulation as novel spectrophotometric methods for the analysis of binary mixtures
  • Zero order and signal processing spectrophotometric techniques applied for resolving interference of metronidazole with ciprofloxacin in their pharmaceutical dosage form
  • Two wavelengths dependant stability indicating spectrophotometric methods for determination of labetalol hydrochloride in the presence of its oxidative degradation product: A Comparative study