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Ecofriendly Spectrophotometric Methods for the Simultaneous Determination of Flupirtine Maleate and Thiocolchicoside: Evaluation of Greenness Profile

Ecofriendly Spectrophotometric Methods for the Simultaneous Determination of Flupirtine Maleate... Abstract The present study represents four simple UV spectrophotometric methods that are accurate, precise, and ecofriendly for estimating flupirtine maleate and thiocolchicoside in pharmaceutical formulation. The four methods are the second order derivative of zero order spectra, the first derivative of ratio spectra, the extended ratio subtraction technique, and the absorption factor method. The proposed methods have linear calibration curves in the range of 14-26 to 2.80-5.2 µg mL-1 for flupirtine maleate and thiocolchicoside, correspondingly. The proposed methods are evaluated toward synthetic mixtures of the drugs as mentioned earlier and then extended to commercial pharmaceutical formulations of the analytes of interest. The findings of the assay for determining the cited drugs in pharmaceutical tablets were statistically analysed with those of the published HPLC method, implying that no discernible difference exists between the suggested and published procedures. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. The methods have been validated according to ICH criteria and confirmed to be within acceptable limits. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Ecofriendly Spectrophotometric Methods for the Simultaneous Determination of Flupirtine Maleate and Thiocolchicoside: Evaluation of Greenness Profile

Seetharaman, R; Lakshmi, K S
Analytical Chemistry Letters , Volume 12 (2): 9 – Mar 4, 2022
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Ecofriendly Spectrophotometric Methods for the Simultaneous Determination of Flupirtine Maleate and Thiocolchicoside: Evaluation of Greenness Profile

Abstract

Abstract The present study represents four simple UV spectrophotometric methods that are accurate, precise, and ecofriendly for estimating flupirtine maleate and thiocolchicoside in pharmaceutical formulation. The four methods are the second order derivative of zero order spectra, the first derivative of ratio spectra, the extended ratio subtraction technique, and the absorption factor method. The proposed methods have linear calibration curves in the range of 14-26 to 2.80-5.2 µg mL-1...
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Publisher
Taylor & Francis
Copyright
© 2022 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2022.2034528
Publisher site
See Article on Publisher Site

Abstract

Abstract The present study represents four simple UV spectrophotometric methods that are accurate, precise, and ecofriendly for estimating flupirtine maleate and thiocolchicoside in pharmaceutical formulation. The four methods are the second order derivative of zero order spectra, the first derivative of ratio spectra, the extended ratio subtraction technique, and the absorption factor method. The proposed methods have linear calibration curves in the range of 14-26 to 2.80-5.2 µg mL-1 for flupirtine maleate and thiocolchicoside, correspondingly. The proposed methods are evaluated toward synthetic mixtures of the drugs as mentioned earlier and then extended to commercial pharmaceutical formulations of the analytes of interest. The findings of the assay for determining the cited drugs in pharmaceutical tablets were statistically analysed with those of the published HPLC method, implying that no discernible difference exists between the suggested and published procedures. The analytical Eco scale, Agree metrics, and Green analytical procedure index was used to assess the method's greenness scores. The methods have been validated according to ICH criteria and confirmed to be within acceptable limits.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Mar 4, 2022

Keywords: Flupirtine maleate; Thiocolchicoside; Second and ratio first derivative; extended ratio subtraction; absorption factor

References

  • Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound
  • The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
  • Developemnt and validation of RP-HPLC method for simultaneous estimation of thiocolchicoside and flupirtine maleate in pharmaceutical dosage form
  • Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Thiocolchicoside and Flupirtine Maleate in Pharmaceutical Formulation
  • A new spectrophotometric method for quantitative multicomponent analysis resolution of mixtures of salicylic and salicyluric acids
  • Smart Stability-Indicating Spectrophotometric Methods for Determination of Binary Mixtures Without Prior Separation
  • Simultaneous determination of some cholesterol-lowering drugs in their binary mixture by novel spectrophotometric methods
  • Validated Absorption Factor Spectrophotometric and Reversed-Phase High-Performance Liquid Chromatographic Methods for the Determination of Ramipril and Olmesartan Medoxomil in Pharmaceutical Formulations Chintan
  • Analytical Eco-Scale for assessing the greenness of analytical procedures
  • A new tool for the evaluation of the analytical procedure: Green Analytical Procedure Index
  • AGREE-Analytical GREEnness Metric Approach and Software
  • Spectrophotometric resolution of ternary mixtures of Dexamethasone, Polymyxin B and Trimethoprim in synthetic and pharmaceutical formulations
  • First derivative spectrophotometric, TLC-densitometric, and HPLC determination of acebutolol HCL in presence of its acid-induced degradation product