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Effect of Endosulfan Organochlorine-based Insecticide on Human Mental Health at the Molecular Level using Panther

Effect of Endosulfan Organochlorine-based Insecticide on Human Mental Health at the Molecular... Abstract Endosulfan is an organochlorine insecticide that is extensively used in agriculture. Humans get exposed to this contaminant either directly through farms or indirectly by consumption of contaminated food. Endosulfan exposure can have serious health consequences including endocrine disruption, infertility, and neurological disorders. However, the central nervous system is the main target of its acute toxicity. In this context, we selected putative genes involved in mental disorders from a comparative toxicogenomics database. Further, pathway analysis was done for targeted disorders using PANTHER. An initial database search shows the involvement of endosulfan in 149 different mental disorders. Among them, we targeted five disorders including Autistic, Alzheimer, Schizophrenia, Intellectual disability, and Cognition. Pathway analysis for these disorders shows the involvement of several pathways from which significant pathways were selected by statistical overrepresentation test analysis. The finding shows that the gonadotropin-releasing hormone receptor pathway was most expected in autistic disorder while CCKR signaling pathway was found to be most expected in Alzheimer’s. In schizophrenia, the most expected pathway was chemokine and cytokine inflammatory pathway. In addition, we also analyzed genes present in most affected pathways. In conclusion, this study shed light on various molecular pathways of mental disorders that are influenced by endosulfan and thereby imparts information about potential genes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Effect of Endosulfan Organochlorine-based Insecticide on Human Mental Health at the Molecular Level using Panther

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Effect of Endosulfan Organochlorine-based Insecticide on Human Mental Health at the Molecular Level using Panther

Abstract

Abstract Endosulfan is an organochlorine insecticide that is extensively used in agriculture. Humans get exposed to this contaminant either directly through farms or indirectly by consumption of contaminated food. Endosulfan exposure can have serious health consequences including endocrine disruption, infertility, and neurological disorders. However, the central nervous system is the main target of its acute toxicity. In this context, we selected putative genes involved in mental disorders...
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Publisher
Taylor & Francis
Copyright
© 2021 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2021.1919547
Publisher site
See Article on Publisher Site

Abstract

Abstract Endosulfan is an organochlorine insecticide that is extensively used in agriculture. Humans get exposed to this contaminant either directly through farms or indirectly by consumption of contaminated food. Endosulfan exposure can have serious health consequences including endocrine disruption, infertility, and neurological disorders. However, the central nervous system is the main target of its acute toxicity. In this context, we selected putative genes involved in mental disorders from a comparative toxicogenomics database. Further, pathway analysis was done for targeted disorders using PANTHER. An initial database search shows the involvement of endosulfan in 149 different mental disorders. Among them, we targeted five disorders including Autistic, Alzheimer, Schizophrenia, Intellectual disability, and Cognition. Pathway analysis for these disorders shows the involvement of several pathways from which significant pathways were selected by statistical overrepresentation test analysis. The finding shows that the gonadotropin-releasing hormone receptor pathway was most expected in autistic disorder while CCKR signaling pathway was found to be most expected in Alzheimer’s. In schizophrenia, the most expected pathway was chemokine and cytokine inflammatory pathway. In addition, we also analyzed genes present in most affected pathways. In conclusion, this study shed light on various molecular pathways of mental disorders that are influenced by endosulfan and thereby imparts information about potential genes.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: May 4, 2021

Keywords: Endosulfan; mental disorder; comparative toxicogenomics database; PANTHER; CCKR pathway

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