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Electro-oxidation and Determination of Procainamide at Glassy Carbon Electrode and its Analytical Applications

Electro-oxidation and Determination of Procainamide at Glassy Carbon Electrode and its Analytical... AbstractAn electrochemical method has been described for the voltammetric oxidation and determination of an antiarrhythmic drug, procainamide (PAH), at a glassy carbon electrode by using cyclic and differential pulse voltammetry (DPV) in phosphate buffer solution under physiological condition, i.e., pH = 7.0. The oxidation process was shown to be irreversible over the pH range studied. PAH undergoes two electron and one proton change and is a diffusion controlled process. The anodic peak current varied linearly with PAH concentration in the range 2.0 × 10-4 to 5.0 × 10-6 M with a limit of detection (LOD) of 1.966 × 10-6 M and limit of quantification (LOQ) 6.554 ×10-6 M. High percentage recovery and study of excipients showed that the method is free from the interferences of the commonly used excipients in the formulations of drug. The proposed method offered advantages of accuracy and time saving as well as simplicity of reagents and apparatus. This method can be employed in clinical analysis, quality control and routine determination of drugs in pharmaceutical formulations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Electro-oxidation and Determination of Procainamide at Glassy Carbon Electrode and its Analytical Applications

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Electro-oxidation and Determination of Procainamide at Glassy Carbon Electrode and its Analytical Applications

Abstract

AbstractAn electrochemical method has been described for the voltammetric oxidation and determination of an antiarrhythmic drug, procainamide (PAH), at a glassy carbon electrode by using cyclic and differential pulse voltammetry (DPV) in phosphate buffer solution under physiological condition, i.e., pH = 7.0. The oxidation process was shown to be irreversible over the pH range studied. PAH undergoes two electron and one proton change and is a diffusion controlled process. The anodic peak...
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Publisher
Taylor & Francis
Copyright
© 2016 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2016.1196606
Publisher site
See Article on Publisher Site

Abstract

AbstractAn electrochemical method has been described for the voltammetric oxidation and determination of an antiarrhythmic drug, procainamide (PAH), at a glassy carbon electrode by using cyclic and differential pulse voltammetry (DPV) in phosphate buffer solution under physiological condition, i.e., pH = 7.0. The oxidation process was shown to be irreversible over the pH range studied. PAH undergoes two electron and one proton change and is a diffusion controlled process. The anodic peak current varied linearly with PAH concentration in the range 2.0 × 10-4 to 5.0 × 10-6 M with a limit of detection (LOD) of 1.966 × 10-6 M and limit of quantification (LOQ) 6.554 ×10-6 M. High percentage recovery and study of excipients showed that the method is free from the interferences of the commonly used excipients in the formulations of drug. The proposed method offered advantages of accuracy and time saving as well as simplicity of reagents and apparatus. This method can be employed in clinical analysis, quality control and routine determination of drugs in pharmaceutical formulations.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: May 3, 2016

Keywords: Procainamide; voltammetry; Glassy carbon electrode; urine analysis; oxidation

References

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