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Iatrogenic cerebral amyloid angiopathy rather than sporadic CAA in younger adults with lobar intracerebral haemorrhage

Iatrogenic cerebral amyloid angiopathy rather than sporadic CAA in younger adults with lobar... AMYLOID https://doi.org/10.1080/13506129.2023.2212394 LETTER TO THE EDITOR Iatrogenic cerebral amyloid angiopathy rather than sporadic CAA in younger adults with lobar intracerebral haemorrhage We must revise our diagnosis. In 2012, in Amyloid,we using human brain homogenates injected in rodent brains reported on two cases of young adults (37 and 42 years old) found that exogenous Ab seeds from various Ab pathologies who experienced recurrent lobar intracerebral haemorrhages induced Ab deposition in the blood vessels rather than in and who were diagnosed with cerebral amyloid angiopathy brain parenchyma [5]. The blood vessel-focused deposition [1]. Diagnosis was confirmed by histological examination was independent of the Ab strain-specific information. These data help to explain why CAA is the predominant and Ab immunostaining of leptomeningeal biopsies. characteristic of iatrogenic Ab transmission. Further Notably, as outlined in 2012, both patients had suffered research is needed to explain the relationship of ApoE geno- from a severe traumatic brain injury (TBI) in childhood [1]. types on the susceptibility to iatrogenic Ab transmissions. In 2022, a 36-year-old woman presented with her fifth spon- While ApoE e2/e4 alleles are associated with an increased taneous intracerebral haemorrhage. Except for recurrent risk of lobar cerebral haemorrhage in sporadic CAA, ApoE intracerebral haemorrhages http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Amyloid Taylor & Francis

Iatrogenic cerebral amyloid angiopathy rather than sporadic CAA in younger adults with lobar intracerebral haemorrhage

Purrucker, J. C.; Röcken, C.; Reuss, D.
Amyloid , Volume 30 (4): 3 – Oct 2, 2023
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Publisher
Taylor & Francis
Copyright
© 2023 Informa UK Limited, trading as Taylor & Francis Group
ISSN
1744-2818
eISSN
1350-6129
DOI
10.1080/13506129.2023.2212394
Publisher site
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Abstract

AMYLOID https://doi.org/10.1080/13506129.2023.2212394 LETTER TO THE EDITOR Iatrogenic cerebral amyloid angiopathy rather than sporadic CAA in younger adults with lobar intracerebral haemorrhage We must revise our diagnosis. In 2012, in Amyloid,we using human brain homogenates injected in rodent brains reported on two cases of young adults (37 and 42 years old) found that exogenous Ab seeds from various Ab pathologies who experienced recurrent lobar intracerebral haemorrhages induced Ab deposition in the blood vessels rather than in and who were diagnosed with cerebral amyloid angiopathy brain parenchyma [5]. The blood vessel-focused deposition [1]. Diagnosis was confirmed by histological examination was independent of the Ab strain-specific information. These data help to explain why CAA is the predominant and Ab immunostaining of leptomeningeal biopsies. characteristic of iatrogenic Ab transmission. Further Notably, as outlined in 2012, both patients had suffered research is needed to explain the relationship of ApoE geno- from a severe traumatic brain injury (TBI) in childhood [1]. types on the susceptibility to iatrogenic Ab transmissions. In 2022, a 36-year-old woman presented with her fifth spon- While ApoE e2/e4 alleles are associated with an increased taneous intracerebral haemorrhage. Except for recurrent risk of lobar cerebral haemorrhage in sporadic CAA, ApoE intracerebral haemorrhages

Journal

Amyloid – Taylor & Francis

Published: Oct 2, 2023

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