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IL-10 Gene Promoter Polymorphisms in Rheumatoid Arthritis: SHORT REPORT

IL-10 Gene Promoter Polymorphisms in Rheumatoid Arthritis: SHORT REPORT IL-10 is an anti-inflammatory cytokine which may modulate disease expression in RA. Three dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression. The -1082*A allele has been associated with low and the -1082*G allele with high in vitro IL-10 production. We have analysed 117 unrelated Caucasoid RA patients and 119 ethnically matched controls. No significant differences in the allele frequencies of the three polymorphisms were found between controls and RA patients. In contrast, a significant association between the -1082*A allele and the (-1082*A/ -819*C/ -592*C) haplotype and IgA RF+ve/IgG RF-ve patients was observed. The association of genotypes encoding low IL-10 production with IgA RF in RA is incompatible with its suggested role in antibody isotype switching. IgA RF has been associated with severe RA and may thus be indirectly correlated with a genotype encoding low IL-10 production. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Rheumatology Taylor & Francis

IL-10 Gene Promoter Polymorphisms in Rheumatoid Arthritis: SHORT REPORT

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References (12)

Publisher
Taylor & Francis
Copyright
© 1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
ISSN
1502-7732
eISSN
0300-9742
DOI
10.1080/030097498441029
Publisher site
See Article on Publisher Site

Abstract

IL-10 is an anti-inflammatory cytokine which may modulate disease expression in RA. Three dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression. The -1082*A allele has been associated with low and the -1082*G allele with high in vitro IL-10 production. We have analysed 117 unrelated Caucasoid RA patients and 119 ethnically matched controls. No significant differences in the allele frequencies of the three polymorphisms were found between controls and RA patients. In contrast, a significant association between the -1082*A allele and the (-1082*A/ -819*C/ -592*C) haplotype and IgA RF+ve/IgG RF-ve patients was observed. The association of genotypes encoding low IL-10 production with IgA RF in RA is incompatible with its suggested role in antibody isotype switching. IgA RF has been associated with severe RA and may thus be indirectly correlated with a genotype encoding low IL-10 production.

Journal

Scandinavian Journal of RheumatologyTaylor & Francis

Published: Jan 1, 1998

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