Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Interspecies Pharmacokinetic Scaling and the Evolutionary-Comparative Paradigm

Interspecies Pharmacokinetic Scaling and the Evolutionary-Comparative Paradigm 1072 B 0 XE NB A UM D . Allometric Adjustments to Pharmacokinetic Time Coordinates ............................... 1090 E . Pharmacokinetic Clocks, Abnutzungstheorie, and Fourth-Dimensional Space .................. 1099 F. Retrospective ................................... 1103 v. ANNOTATED GLOSSARY ............................ 1103 References ......................................... 1114 I. INTRODUCTION For definitions and explanations of terms, see the Annotated Glossary. Anything that allows science to achieve objectives can be part In this global context, a of or otherwise involved in a paradigm. paradigm embraces the shared commitments of a scientific commu- nity [ 11 . Although ambiguities may exist, mature scientific com - munities can usually determine their paradigms with relative ease [ 21. In pharmacokinetics, three basic paradigms have been iden- tified [ 31 : the methodological, ontogenetic, and evolutionary-com- parative. The methodological paradigm entails the development of models capable of abstracting relevant characteristics of pharma- cokinetic systems [ 41. The ontogenetic paradigm seeks to opti- mize the time-course of drug and metabolite levels in response to transient or progressive changes occurring within cells and tis- sues during an organism's lifetime. The third, or evolutionary- comparative paradigm infers the existence of a basic pharmacoki- netic rhythm intrinsic to the organism. It looks for differences in genetically determined http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Metabolism Reviews Taylor & Francis

Interspecies Pharmacokinetic Scaling and the Evolutionary-Comparative Paradigm

Drug Metabolism Reviews , Volume 15 (5-6): 51 – Jan 1, 1984

Interspecies Pharmacokinetic Scaling and the Evolutionary-Comparative Paradigm

Drug Metabolism Reviews , Volume 15 (5-6): 51 – Jan 1, 1984

Abstract

1072 B 0 XE NB A UM D . Allometric Adjustments to Pharmacokinetic Time Coordinates ............................... 1090 E . Pharmacokinetic Clocks, Abnutzungstheorie, and Fourth-Dimensional Space .................. 1099 F. Retrospective ................................... 1103 v. ANNOTATED GLOSSARY ............................ 1103 References ......................................... 1114 I. INTRODUCTION For definitions and explanations of terms, see the Annotated Glossary. Anything that allows science to achieve objectives can be part In this global context, a of or otherwise involved in a paradigm. paradigm embraces the shared commitments of a scientific commu- nity [ 11 . Although ambiguities may exist, mature scientific com - munities can usually determine their paradigms with relative ease [ 21. In pharmacokinetics, three basic paradigms have been iden- tified [ 31 : the methodological, ontogenetic, and evolutionary-com- parative. The methodological paradigm entails the development of models capable of abstracting relevant characteristics of pharma- cokinetic systems [ 41. The ontogenetic paradigm seeks to opti- mize the time-course of drug and metabolite levels in response to transient or progressive changes occurring within cells and tis- sues during an organism's lifetime. The third, or evolutionary- comparative paradigm infers the existence of a basic pharmacoki- netic rhythm intrinsic to the organism. It looks for differences in genetically determined

Loading next page...
 
/lp/taylor-francis/interspecies-pharmacokinetic-scaling-and-the-evolutionary-comparative-OTW02r8Bqm

References (95)

Publisher
Taylor & Francis
Copyright
© 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
ISSN
1097-9883
eISSN
0360-2532
DOI
10.3109/03602538409033558
Publisher site
See Article on Publisher Site

Abstract

1072 B 0 XE NB A UM D . Allometric Adjustments to Pharmacokinetic Time Coordinates ............................... 1090 E . Pharmacokinetic Clocks, Abnutzungstheorie, and Fourth-Dimensional Space .................. 1099 F. Retrospective ................................... 1103 v. ANNOTATED GLOSSARY ............................ 1103 References ......................................... 1114 I. INTRODUCTION For definitions and explanations of terms, see the Annotated Glossary. Anything that allows science to achieve objectives can be part In this global context, a of or otherwise involved in a paradigm. paradigm embraces the shared commitments of a scientific commu- nity [ 11 . Although ambiguities may exist, mature scientific com - munities can usually determine their paradigms with relative ease [ 21. In pharmacokinetics, three basic paradigms have been iden- tified [ 31 : the methodological, ontogenetic, and evolutionary-com- parative. The methodological paradigm entails the development of models capable of abstracting relevant characteristics of pharma- cokinetic systems [ 41. The ontogenetic paradigm seeks to opti- mize the time-course of drug and metabolite levels in response to transient or progressive changes occurring within cells and tis- sues during an organism's lifetime. The third, or evolutionary- comparative paradigm infers the existence of a basic pharmacoki- netic rhythm intrinsic to the organism. It looks for differences in genetically determined

Journal

Drug Metabolism ReviewsTaylor & Francis

Published: Jan 1, 1984

There are no references for this article.