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Marked improvement of overall survival in mantle cell lymphoma: a population based study from the Swedish Lymphoma Registry

Marked improvement of overall survival in mantle cell lymphoma: a population based study from the... AbstractIn recent years, more intensive chemotherapy regimens for mantle cell lymphoma (MCL) have been associated with prolongation of survival. In this study, our aim was to investigate prognostic factors and evaluate improvement in survival in MCL on a population level. The cohort included all patients diagnosed with MCL from 1 January 2000 to 31 March 2010 in the Swedish Lymphoma Registry. At total of 785 patients with MCL were identified. Age, performance status, and B-symptoms were significant prognostic factors for overall survival (OS) in multivariate analysis. In addition, OS was markedly improved (hazard ratio 0.8, 95% confidence interval 0.7–0.9) for patients diagnosed during the latest time period, 2006–2010, also when corrected for prognostic factors as above. Estimated OS at 3 years was 62%, compared to 47% for patients diagnosed earlier (p < 0.01). The reasons for this dramatic improvement in OS are not yet clear, but may be due to the introduction of specific and more potent therapeutic regimens. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Leukemia & Lymphoma Taylor & Francis

Marked improvement of overall survival in mantle cell lymphoma: a population based study from the Swedish Lymphoma Registry

Leukemia & Lymphoma , Volume 52 (10): 7 – Oct 1, 2011
7 pages

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References (12)

Publisher
Taylor & Francis
Copyright
© 2011 Informa Uk, Ltd.
ISSN
1029-2403
eISSN
1042-8194
DOI
10.3109/10428194.2011.587560
pmid
21702648
Publisher site
See Article on Publisher Site

Abstract

AbstractIn recent years, more intensive chemotherapy regimens for mantle cell lymphoma (MCL) have been associated with prolongation of survival. In this study, our aim was to investigate prognostic factors and evaluate improvement in survival in MCL on a population level. The cohort included all patients diagnosed with MCL from 1 January 2000 to 31 March 2010 in the Swedish Lymphoma Registry. At total of 785 patients with MCL were identified. Age, performance status, and B-symptoms were significant prognostic factors for overall survival (OS) in multivariate analysis. In addition, OS was markedly improved (hazard ratio 0.8, 95% confidence interval 0.7–0.9) for patients diagnosed during the latest time period, 2006–2010, also when corrected for prognostic factors as above. Estimated OS at 3 years was 62%, compared to 47% for patients diagnosed earlier (p < 0.01). The reasons for this dramatic improvement in OS are not yet clear, but may be due to the introduction of specific and more potent therapeutic regimens.

Journal

Leukemia & LymphomaTaylor & Francis

Published: Oct 1, 2011

Keywords: Mantle cell lymphoma; population; Swedish Lymphoma Registry

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