Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Modified Screen-Printed and Carbon Paste as Ion-Selective Electrodes for the Determination of Ramipril Drug in Pharmaceutical and Biological Samples

Modified Screen-Printed and Carbon Paste as Ion-Selective Electrodes for the Determination of... AbstractRamipril was a prodrug and it was an angiotensin converting enzyme (ACE) inhibitor which can be used to treat congestive heart failure and hypertension. In this study, the electro activity and the performance characteristics of modified screen-printed (MSPEs) and carbon paste (MCPEs) electrodes with different types of ion pairs had been studied in order to determine ramipril (RAM) drug in pure solution, pharmaceutical formulations and biological fluid samples. The ion pair formation between RAM and phosphomolybdic acid (PMA) or phosphotungstic acid (PTA) or sodium teteraphenyl borate (Na-TPB) was the basis of preparation of modified ion selective electrodes used in this study. The surface analysis of the electrodes was studied using scanning electron microscope (SEM) and X-ray diffraction (XRD). The electrodes showed linear response with good Nernstian slope of 58.50±1.08, 59.00±0.96, 59.60±0.73 mV decade-1 for MSPEs modified with RAM-TPB, RAM-PMA and RAM-PTA ion pairs, respectively, and 59.20±0.96, 58.90±1.01 mV decade-1 for MCPEs modified with RAM-TPB and RAM-PTA ion pairs, respectively, over the concentration range from 5.0 x 10-7 to 1.0 x 10-2 mol L-1. Although, the two types of electrodes provided response time of about 4 s for MSPEs and 5 s for MCPEs and exhibited lifetimes of 99 to 92 days for MSPE electrodes and 67 days for both electrodes of MCPEs on pH range from 2 to 5 for MSPEs and 2 to 4 for MCPEs. They showed high thermal stability according to the isothermal coefficients values. Selectivity coefficients of RAM sensors relative to a number of potential interfering materials were investigated. The developed method was found to be simple, precise and accurate when compared with the reported method. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Modified Screen-Printed and Carbon Paste as Ion-Selective Electrodes for the Determination of Ramipril Drug in Pharmaceutical and Biological Samples

Download PDF

Modified Screen-Printed and Carbon Paste as Ion-Selective Electrodes for the Determination of Ramipril Drug in Pharmaceutical and Biological Samples

Abstract

AbstractRamipril was a prodrug and it was an angiotensin converting enzyme (ACE) inhibitor which can be used to treat congestive heart failure and hypertension. In this study, the electro activity and the performance characteristics of modified screen-printed (MSPEs) and carbon paste (MCPEs) electrodes with different types of ion pairs had been studied in order to determine ramipril (RAM) drug in pure solution, pharmaceutical formulations and biological fluid samples. The ion pair formation...
Loading next page...
 
/lp/taylor-francis/modified-screen-printed-and-carbon-paste-as-ion-selective-electrodes-G1c00H3yFE
Publisher
Taylor & Francis
Copyright
© 2019 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2019.1645042
Publisher site
See Article on Publisher Site

Abstract

AbstractRamipril was a prodrug and it was an angiotensin converting enzyme (ACE) inhibitor which can be used to treat congestive heart failure and hypertension. In this study, the electro activity and the performance characteristics of modified screen-printed (MSPEs) and carbon paste (MCPEs) electrodes with different types of ion pairs had been studied in order to determine ramipril (RAM) drug in pure solution, pharmaceutical formulations and biological fluid samples. The ion pair formation between RAM and phosphomolybdic acid (PMA) or phosphotungstic acid (PTA) or sodium teteraphenyl borate (Na-TPB) was the basis of preparation of modified ion selective electrodes used in this study. The surface analysis of the electrodes was studied using scanning electron microscope (SEM) and X-ray diffraction (XRD). The electrodes showed linear response with good Nernstian slope of 58.50±1.08, 59.00±0.96, 59.60±0.73 mV decade-1 for MSPEs modified with RAM-TPB, RAM-PMA and RAM-PTA ion pairs, respectively, and 59.20±0.96, 58.90±1.01 mV decade-1 for MCPEs modified with RAM-TPB and RAM-PTA ion pairs, respectively, over the concentration range from 5.0 x 10-7 to 1.0 x 10-2 mol L-1. Although, the two types of electrodes provided response time of about 4 s for MSPEs and 5 s for MCPEs and exhibited lifetimes of 99 to 92 days for MSPE electrodes and 67 days for both electrodes of MCPEs on pH range from 2 to 5 for MSPEs and 2 to 4 for MCPEs. They showed high thermal stability according to the isothermal coefficients values. Selectivity coefficients of RAM sensors relative to a number of potential interfering materials were investigated. The developed method was found to be simple, precise and accurate when compared with the reported method.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: May 4, 2019

Keywords: Ramipril; modified screen printed and carbon paste electrodes; scanning electron microscope; pharmaceutical preparations; and biological fluids samples

References

  • A spectrophotometric method for the determination of ramipril in solid dosage forms
  • Spectrophotometric determination of enalapril maleate and ramipril in dosage forms
  • Kinetic spectrophotometric method for the determination of ramipril in pharmaceutical formulations
  • Spectrophotometric and spectrofluorimetric methods for the determination of ramipril in its pure and dosage form
  • Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules
  • Liquid chromatography-mass spectrometry method for determination of ramipril and its active metabolite ramiprilat in human plasma
  • Development of a method for the detection of Angiotensin converting enzyme inhibitors using Electron Capture-Gas Chromatography detection
  • Hochempfindliche GC/MS-MethodezurBestimmung des stabilen Prostacyclin Metaboliten 6-oxo-PGF 1α in Humanurin, Fresenius
  • Spectrophotometric and atomic absorption spectrometric determination of ramipril and perindopril through ternary complex formation with eosin and Cu (II), J
  • Enalapril and Ramipril Selective Membranes
  • Preparation, Characterization, and Analytical Application of Ramipril Membrane-Based Ion-Selective Electrode
  • Simultaneous determination of hydrochlorothiazide and several inhibitors of angiotensin-converting enzyme by capillary electrophoresis
  • A radioimmunoassay for the angiotensin converting enzyme inhibitor ramipril and its active metabolite
  • In situ modified screen printed and carbon paste ion selective electrodes for potentiometric determination of naphazoline hydrochloride in its formulation
  • Carbon paste and PVC electrodes for the flow injection potentiometric determination of dextromethorphan
  • Modified screen printed and carbon paste ion selective electrodes for potentiometric determination of naphazoline hydro-chloride in pure and pharmaceutical preparations
  • Groove electrodes: A new alternative of using carbon pastes in electroanalysis
  • Electrochemical characterization of screen-printed and conventional carbon paste electrodes
  • Determination of phosphorus and tungsten in heteropoly acids by EDTA-titration
  • Potentiometric titration of thallium (I) with sodium tetraphenylborate, using ion-selective electrodes
  • Construction and performance characterization of screen printed and carbon paste ion selective electrodes for potentiometric determination of naphazoline hydrochloride in pharmaceutical preparations
  • Potentiometric determination of antihistaminic diphenhydramine hydrochloride in pharmaceutical preparations and biological fluids using screen-printed electrode
  • Construction of modified screen-printed and carbon paste electrodes for electrochemical determination of antihistaminic diphenhydramine hydrochloride in pure and pharmaceutical preparations
  • Construction and performance characterization of ion selective electrodes for potentiometric determination of ranitidine hydrochloride in pharmaceutical preparations and biological fluids
  • Disposable screen-printed sensors for determination of duloxetine hydrochloride
  • Comparative Study of Different Modified Potentiometric Sensors for Determination of Moxifloxacin HCl in Dosage Forms
  • Voltammetry with carbon paste electrodes containing membrane plasticizers used for PVC-based ion-selective electrodes
  • “Recommendations for nomenclature of ionselective electrodes (IUPAC Recommendations
  • Electrochemical study of ivabradine hydrochloride ion selective electrodes using different ionophores
  • Ceram
  • Studies on potentiometric titrations using simple liquied membrane-based electrodes: coated wire VS. Carbon pastes, Scientific papers of the University of Pardubice. Series A
  • A novel naphazoline-selective membrane sensor and its pharmaceutical applications
  • The maximum hydrogen (deuterium) loading ratio in the Pd| H2O (D2O) electrochemical system
  • Polymer membrane sensors for sildenafil citrate (Viagra) determination in pharmaceutical preparations
  • A novel potassium ion membrane sensor based on rifamycin neutral ionophore
  • Potentiometric selectivity coefficients of ion-selective electrodes. Part I. Inorganic cations (technical report)
  • Quantitative determination of telmisartan, ramipril, amlodipine besylate, and atorvastatin calcium by HPLC. J. Liq
  • Novel and selective potentiometric membrane sensor for amiloride determination in pharmaceutical compounds and urine
  • A novel naphazoline-selective membrane sensor and its pharmaceutical applications
  • United States of Pharmacopeia-National Formulary, USP30-NF25