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Pesticides, Chromosomal Aberrations, and Non-Hodgkin's Lymphoma

Pesticides, Chromosomal Aberrations, and Non-Hodgkin's Lymphoma An excessive incidence of non-Hodgkin's lymphoma (NHL) has been reported among farmers and other occupational groups working with pesticides. Some pesticides exhibit immunotoxic and genotoxic activities. Individuals exposed to pesticides have also been found to have an increased prevalence of chromosomal abnormalities including the t(14;18)(q32;q21), one of the most common chromosomal abnormalities in NHL. Two recent epidemiologic studies reported that the association between pesticide exposures and risk of NHL was largely limited to NHL cases with the chromosomal translocation t(14;18). This review summarizes the findings from these epidemiologic studies, speculates on implications, and suggests the research needed to clarify the role of pesticides in NHL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal Of Agromedicine Taylor & Francis

Pesticides, Chromosomal Aberrations, and Non-Hodgkin's Lymphoma

Journal Of Agromedicine , Volume 14 (2): 6 – May 7, 2009
6 pages

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References (21)

Publisher
Taylor & Francis
Copyright
Copyright Taylor & Francis Group, LLC
ISSN
1545-0813
eISSN
1059-924X
DOI
10.1080/10599240902773140
pmid
19437285
Publisher site
See Article on Publisher Site

Abstract

An excessive incidence of non-Hodgkin's lymphoma (NHL) has been reported among farmers and other occupational groups working with pesticides. Some pesticides exhibit immunotoxic and genotoxic activities. Individuals exposed to pesticides have also been found to have an increased prevalence of chromosomal abnormalities including the t(14;18)(q32;q21), one of the most common chromosomal abnormalities in NHL. Two recent epidemiologic studies reported that the association between pesticide exposures and risk of NHL was largely limited to NHL cases with the chromosomal translocation t(14;18). This review summarizes the findings from these epidemiologic studies, speculates on implications, and suggests the research needed to clarify the role of pesticides in NHL.

Journal

Journal Of AgromedicineTaylor & Francis

Published: May 7, 2009

Keywords: Chromosomal abnormalities; epidemiology; lymphoma; pesticides; t(14;18)

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