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Progress in the molecular diagnosis of Lyme disease

Progress in the molecular diagnosis of Lyme disease Introduction: Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered.Areas covered: This review represent summary and discussion of the published data obtained from literature searches from PubMed and The National Library of Medicine (USA) together with our own experience on molecular diagnosis of Lyme disease.Expert commentary: Molecular methods are promising and currently serve as supporting diagnostic testing in Lyme borreliosis. Since the field of molecular diagnostics is under rapid development, molecular testing could become an important diagnostic modality. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Expert Review of Molecular Diagnostics Taylor & Francis

Progress in the molecular diagnosis of Lyme disease

Progress in the molecular diagnosis of Lyme disease

Expert Review of Molecular Diagnostics , Volume 17 (1): 12 – Jan 2, 2017

Abstract

Introduction: Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered.Areas covered: This review represent summary and discussion of the published data obtained from literature searches from PubMed and The National Library of Medicine (USA) together with our own experience on molecular diagnosis of Lyme disease.Expert commentary: Molecular methods are promising and currently serve as supporting diagnostic testing in Lyme borreliosis. Since the field of molecular diagnostics is under rapid development, molecular testing could become an important diagnostic modality.

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References (173)

Publisher
Taylor & Francis
Copyright
© 2016 Informa UK Limited, trading as Taylor & Francis Group
ISSN
1744-8352
eISSN
1473-7159
DOI
10.1080/14737159.2016.1246959
Publisher site
See Article on Publisher Site

Abstract

Introduction: Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered.Areas covered: This review represent summary and discussion of the published data obtained from literature searches from PubMed and The National Library of Medicine (USA) together with our own experience on molecular diagnosis of Lyme disease.Expert commentary: Molecular methods are promising and currently serve as supporting diagnostic testing in Lyme borreliosis. Since the field of molecular diagnostics is under rapid development, molecular testing could become an important diagnostic modality.

Journal

Expert Review of Molecular DiagnosticsTaylor & Francis

Published: Jan 2, 2017

Keywords: Borrelia burgdorferi sensu lato; Lyme borreliosis; PCR; molecular methods; molecular diagnostics; serology; erythema migrans; Lyme neuroborreliosis; acrodermatitis chronica atrophicans; cerebrospinal fluid

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