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Psychic Disturbances in Adult Coeliac Disease

Psychic Disturbances in Adult Coeliac Disease Untreated adult coeliac patients have previously been shown to have a high frequency of depressive symptoms as reported in a personality inventory (the MMPI). In the present study we determined the concentrations of three major monoamine metabolites in samples of lumbar cerebrospinal fluid of ten consecutive adults with newly detected coeliac disease. They showed significant reduction in levels of 5-HIAA (70.3 ± 25.4 pmol/ml), HVA (128.2 ± 58.3 pmol/ml), and MOPEG (27.7 ± 7.4 pmol/ml), indicating reduced central metabolism in all three monoamine pathways. The concentrations, in particular that of MOPEG, were inversely correlated with depressive symptoms reported on the MMPI scale 2 (‘depression’), which conforms with current concepts on the pathogenesis of depression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Gastroenterology Taylor & Francis

Psychic Disturbances in Adult Coeliac Disease

Psychic Disturbances in Adult Coeliac Disease

Scandinavian Journal of Gastroenterology , Volume 17 (1): 4 – Jan 1, 1982

Abstract

Untreated adult coeliac patients have previously been shown to have a high frequency of depressive symptoms as reported in a personality inventory (the MMPI). In the present study we determined the concentrations of three major monoamine metabolites in samples of lumbar cerebrospinal fluid of ten consecutive adults with newly detected coeliac disease. They showed significant reduction in levels of 5-HIAA (70.3 ± 25.4 pmol/ml), HVA (128.2 ± 58.3 pmol/ml), and MOPEG (27.7 ± 7.4 pmol/ml), indicating reduced central metabolism in all three monoamine pathways. The concentrations, in particular that of MOPEG, were inversely correlated with depressive symptoms reported on the MMPI scale 2 (‘depression’), which conforms with current concepts on the pathogenesis of depression.

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References (30)

Publisher
Taylor & Francis
Copyright
© 1982 Informa UK Ltd
ISSN
1502-7708
eISSN
0036-5521
DOI
10.3109/00365528209181039
Publisher site
See Article on Publisher Site

Abstract

Untreated adult coeliac patients have previously been shown to have a high frequency of depressive symptoms as reported in a personality inventory (the MMPI). In the present study we determined the concentrations of three major monoamine metabolites in samples of lumbar cerebrospinal fluid of ten consecutive adults with newly detected coeliac disease. They showed significant reduction in levels of 5-HIAA (70.3 ± 25.4 pmol/ml), HVA (128.2 ± 58.3 pmol/ml), and MOPEG (27.7 ± 7.4 pmol/ml), indicating reduced central metabolism in all three monoamine pathways. The concentrations, in particular that of MOPEG, were inversely correlated with depressive symptoms reported on the MMPI scale 2 (‘depression’), which conforms with current concepts on the pathogenesis of depression.

Journal

Scandinavian Journal of GastroenterologyTaylor & Francis

Published: Jan 1, 1982

Keywords: Biogenic amines; cerebrospinal fluid; coeliac disease; depression; MMPI

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