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Spectrofluorimetric Determination of Triamterene in Different Body Fluids and Pharmaceutical Tablets

Spectrofluorimetric Determination of Triamterene in Different Body Fluids and Pharmaceutical Tablets Abstract A spectrofluorimetric method is used to determine 6-phenylpteridine-2,4,27-triamine in pharmaceutical dosage form, Urine and human serum samples. The method is simple, sensitive, and accurate and based on the fluorescence enhancement with increasing concentration of the highly fluorescent triamterene containing three amino groups in methanol at pH 6.7. The dynamic range for the determination of triamterene is 5×10-10 – 9.5×10-7 mol L-1 with detection limit and quantitative detection limit (LOD and LOQ) of 2x10-10 and 6.6x10-10, mol L-1, respectively. The low values of LOD and LOQ indicate the high sensitivity of the proposed method if compared to previous methods for the determination of triamterene. Percentage recoveries were found to be 99.30 ± 0.65, 98.6 ± 0.75, and 96.60 ± 0.85 for the pharmaceutical tablets, urine, and serum samples, respectively. The results demonstrated the accuracy as well as the precision of the proposed method. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Spectrofluorimetric Determination of Triamterene in Different Body Fluids and Pharmaceutical Tablets

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Spectrofluorimetric Determination of Triamterene in Different Body Fluids and Pharmaceutical Tablets

Abstract

Abstract A spectrofluorimetric method is used to determine 6-phenylpteridine-2,4,27-triamine in pharmaceutical dosage form, Urine and human serum samples. The method is simple, sensitive, and accurate and based on the fluorescence enhancement with increasing concentration of the highly fluorescent triamterene containing three amino groups in methanol at pH 6.7. The dynamic range for the determination of triamterene is 5×10-10 – 9.5×10-7 mol L-1 with detection limit and...
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Publisher
Taylor & Francis
Copyright
Copyright Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2011.10648215
Publisher site
See Article on Publisher Site

Abstract

Abstract A spectrofluorimetric method is used to determine 6-phenylpteridine-2,4,27-triamine in pharmaceutical dosage form, Urine and human serum samples. The method is simple, sensitive, and accurate and based on the fluorescence enhancement with increasing concentration of the highly fluorescent triamterene containing three amino groups in methanol at pH 6.7. The dynamic range for the determination of triamterene is 5×10-10 – 9.5×10-7 mol L-1 with detection limit and quantitative detection limit (LOD and LOQ) of 2x10-10 and 6.6x10-10, mol L-1, respectively. The low values of LOD and LOQ indicate the high sensitivity of the proposed method if compared to previous methods for the determination of triamterene. Percentage recoveries were found to be 99.30 ± 0.65, 98.6 ± 0.75, and 96.60 ± 0.85 for the pharmaceutical tablets, urine, and serum samples, respectively. The results demonstrated the accuracy as well as the precision of the proposed method.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Jan 1, 2011

Keywords: Triamterene; Fluorescence; Enhancement; Solvent effect; Methanol

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