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Spectrophotometric Analysis of Azithromycin and Clarithromycin in Tablets and Human Plasma Using p-Chloranilic Acid

Spectrophotometric Analysis of Azithromycin and Clarithromycin in Tablets and Human Plasma Using... AbstractA novel spectrophotometric method for rapid estimation of clarithromycin and azithromycin in authentic sample, pharmaceutical dosage forms and in human plasma was developed using p-chloranilic acid. The method depends on charge transfer reaction between p-chloranilic acid and the mentioned drugs. Linearity was observed over a concentration range of 5 to 50 μg/mL-1 clarithromycin and azithromycin. The results indicate that the proposed method is very sensitive, rapid, accurate, selective, and reproducible. The method was validated according to ICH guidelines. The method has been successfully applied for the analysis of marketed formulations and spiked human plasma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Spectrophotometric Analysis of Azithromycin and Clarithromycin in Tablets and Human Plasma Using p-Chloranilic Acid

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Spectrophotometric Analysis of Azithromycin and Clarithromycin in Tablets and Human Plasma Using p-Chloranilic Acid

Abstract

AbstractA novel spectrophotometric method for rapid estimation of clarithromycin and azithromycin in authentic sample, pharmaceutical dosage forms and in human plasma was developed using p-chloranilic acid. The method depends on charge transfer reaction between p-chloranilic acid and the mentioned drugs. Linearity was observed over a concentration range of 5 to 50 μg/mL-1 clarithromycin and azithromycin. The results indicate that the proposed method is very sensitive, rapid, accurate,...
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Publisher
Taylor & Francis
Copyright
© 2019 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2018.1483266
Publisher site
See Article on Publisher Site

Abstract

AbstractA novel spectrophotometric method for rapid estimation of clarithromycin and azithromycin in authentic sample, pharmaceutical dosage forms and in human plasma was developed using p-chloranilic acid. The method depends on charge transfer reaction between p-chloranilic acid and the mentioned drugs. Linearity was observed over a concentration range of 5 to 50 μg/mL-1 clarithromycin and azithromycin. The results indicate that the proposed method is very sensitive, rapid, accurate, selective, and reproducible. The method was validated according to ICH guidelines. The method has been successfully applied for the analysis of marketed formulations and spiked human plasma.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: May 4, 2019

Keywords: Spectrophotometric; azithromycin; clarithromycin; p-chloranilic acid; human plasma

References

  • Chemistry and mode of action of macrolides
  • Spectrophotometric Estimation of Azithromycin in Tablets
  • Novel spectrophotometric method for the determination of azithromycin in pharmaceutical formulations based on its charge transfer reaction with quinalizarin
  • New Spectrophoto-metric Method for Azithromycin Determination
  • Determination of Azithromycin in pharmaceutical dosage forms by Spectrophotometric method
  • Spectrophotometric Analysis of Azithromycin and its. Pharmaceutical Dosage Forms: Comparison between Spectrophotometry and HPLC
  • Development of a Simple RP-HPLC-UV Method for Determination of Azithromycin in Bulk and Pharmaceutical Dosage forms as an Alternative to the USP Method
  • Development and application of liquid chromatographic method for determination of azithromycin in fixed dosage form
  • Determination of azithromycin in raw materials and pharmaceutical formulations by HPLC coupled with an evaporative light scattering detector
  • Analysis of azithromycin and its related compounds by RP-HPLC with UV detection
  • Method development and validation of HPLC method for determination of azithromycin
  • A study of the electrochemical activity of some macrolide antibiotics on a gold electrode in a neutral electrolyte
  • Adsorptive stripping voltammetric determination of azithromycin at a glassy carbon electrode modified by electrochemical oxidation
  • Fluorescence Determination of Azithromycin in Pharmaceutical Formulations by Using the Synchronous Scanning Approach After its Acid Derivatization
  • A validated spectrofluorometric assay for the determination of certain macrolide antibiotics in pharmaceutical formulations and spiked biological fluids
  • Spectrofluorimetric determination of macrolide antibiotics using eosin-G dye
  • Determination of azithromycin in human plasma by LC-MS-MS and its pharmacokinetics
  • Azithromycin and the Risk of Cardiovascular Death”
  • Simple UV spectrophotometric assay of Clarithromycin
  • Development of UV Spectrophotometric Method for Estimation of Clarithromycin in Pharmaceutical DosageForms by using Folin-Ciocalteu Reagent
  • Simple Spectrophotometric Methods for Determination of Clarithromycin in Pure State and Tablets
  • Spectrophotometric Determination of Clarithromycin Based on the Charge Transfer Reaction between Clarithromycin and Purpurin
  • New Spectrophotometric and Conductometric Methods for Macrolide Antibiotics Determination in Pure and Pharmaceutical Dosage Forms Using Rose Bengal
  • Rapid High Performance Liquid Chromatographic Method for Determination of Clarithromycin in Human Plasma Using Amperometric Detection: Application in Pharmacokinetic and Bioequivalence Studies
  • Liquid chromatographic determination of the macrolide antibiotics roxithromycin and clarithromycin in plasma by automated solid-phase extraction an electrochemical detection
  • Sensitive Liquid Chromatographic Determination of Clarithromycin and 14-Hydroxy Clarithromycin in Human Plasma with Tandem Mass Spectrometry
  • Determination and Stability Assessment of Clarithromycin in Human Plasma using RP-LC with Electrochemical Detection
  • Sensitive polarographic electrochemical determination of clarithromycin in blood Serum
  • The qualitative electrochemical determination of clarithromycin and spectroscopic detection of its structural changes at gold electrode
  • Spectrofluorimetric analysis of certain macrolide antibiotics in bulk and pharmaceutical formulations
  • LC-MS/MS method for the simultaneous determination of clarithromycin, rifampicin and their main metabolites in horse plasma, epithelial lining fluid and broncho-alveolar cells
  • Analysis of Certain Tetracyclines and Oxytetracyclines through Charge Transfer Complexation
  • Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate
  • Analytical study of charge transfer complexation of rabeprazole with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone
  • Method of Continuous Variations: applications of job plots to the molecular associations in organometallic chemistry
  • Spectrophotometric Determination of Certain Macrolide Antibiotics in Pharmaceutical Preparations