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Spectrophotometric Determination of Olanzapine in the Presence of its Acidic Degradation Product; Application of Kinetic Study

Spectrophotometric Determination of Olanzapine in the Presence of its Acidic Degradation Product;... AbstractSimple, accurate, selective and sensitive UV spectrophotometric methods have been developed and validated for the determination of olanzapine (OLZ) in presence of its acidic degradation product without preliminary separation. These methods include ratio subtraction, absorbance subtraction and amplitude modulation methods. Ratio subtraction method was used to study the kinetic of OLZ acidic degradation that was found to follow a pseudo-first-order reaction. The t1/2 was 4.91 hours while k (reaction rate constant) was 0.1411h-1. These methods were based on extension region of the degradation product. All the proposed methods were validated and successfully applied for determination of OLZ in Olanza® 5 mg tablets. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Spectrophotometric Determination of Olanzapine in the Presence of its Acidic Degradation Product; Application of Kinetic Study

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Spectrophotometric Determination of Olanzapine in the Presence of its Acidic Degradation Product; Application of Kinetic Study

Abstract

AbstractSimple, accurate, selective and sensitive UV spectrophotometric methods have been developed and validated for the determination of olanzapine (OLZ) in presence of its acidic degradation product without preliminary separation. These methods include ratio subtraction, absorbance subtraction and amplitude modulation methods. Ratio subtraction method was used to study the kinetic of OLZ acidic degradation that was found to follow a pseudo-first-order reaction. The t1/2 was 4.91 hours...
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Publisher
Taylor & Francis
Copyright
© 2017 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2017.1372207
Publisher site
See Article on Publisher Site

Abstract

AbstractSimple, accurate, selective and sensitive UV spectrophotometric methods have been developed and validated for the determination of olanzapine (OLZ) in presence of its acidic degradation product without preliminary separation. These methods include ratio subtraction, absorbance subtraction and amplitude modulation methods. Ratio subtraction method was used to study the kinetic of OLZ acidic degradation that was found to follow a pseudo-first-order reaction. The t1/2 was 4.91 hours while k (reaction rate constant) was 0.1411h-1. These methods were based on extension region of the degradation product. All the proposed methods were validated and successfully applied for determination of OLZ in Olanza® 5 mg tablets. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Sep 3, 2017

Keywords: Olanzapine; kinetics study; ratio subtraction; absorbance subtraction; amplitude modulation

References

  • Applied Pharmacokinetics & Pharmacodynamics. Principles of Therapeutic Drug Monitoring
  • Batch and flow-injection methods for the spectrophotometric determination of olanzapine
  • Spectrophotometric determination of olanzapine by its oxidation with n-bromosuccinimide and cerium (iv) sulfate
  • Monatsh. Kinetic and maximum-absorbance spectrophotometric methods for the determination of olanzapine
  • Determination of olanzapine by spectrophotometry using Permanganate
  • Spectrophotometric determination of antipsychotic drug olanzapine in pharmaceuticals
  • Quantitative determination of olanzapine in tablets with visible spectrophotometry using cerium(iv) sulphate and based on redox and complexation reactions
  • Highly sensitive spectrophotometric determination of olanzapine using cerium(iv) and iron(ii) complexes of 1,10-phenanthroline and 2,2'-bipyridyl
  • Sensitive and selective methods for the determination of olanzapine in pharmaceuticals using N-bromosuccinimide and two dyes
  • New extractive spectrophotometric methods for the determination of olanzapine in pharmaceutical formulations using bromocresol green
  • Development and validation of a stability indicating uv spectroscopic method for olanzapine in bulk and pharmaceutical dosage forms
  • Extractive Spectrophotometric Method for the Determination of Some Antipsychotic Drugs Using Eriochrome Black T
  • Quantitation of olanzapine in tablets by HPLC, CZE,derivative spectrometry and linear voltammetry
  • Development of a modified electrode with amine-functionalized TiO2/multi-walled carbon nanotubes nanocomposite for electrochemical sensing of the atypical neuroleptic drug olanzapine
  • Voltammetric, spectrophotometric and high performance liquid chromatographic analysis of olanzapine
  • Electrochemical Studies for the Determination of Quetiapine Fumarate and Olanzapine Antipsychotic Drugs
  • Electrochemical studies and selective detection of thioridazine using a carbon paste electrode modified with zns nanoparticles and simultaneous determination of thioridazine and olanzapine
  • Determination of olanzapine by uv spectrophotometry and non-aqueous titration
  • Microtitrimetric determination of a drug content of pharmaceuticals containing olanzapine in non-aqueous medium
  • Simultaneous determination of olanzapine and fluoxetine hydrochloride in capsules by spectrophotometry, TLC-spectrodensitometry and HPLC
  • Quantitative determination of olanzapine in pharmaceutical preparations by HPLC
  • Determination of olanzapine in serum by high-performance liquid chromatography using ultraviolet detection considering the easy oxidability of the compound and the presence of other psychotropic drugs
  • Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography
  • Determination of olanzapine in plasma by high-performance liquid chromatography using ultraviolet absorbance detection
  • Assay of olanzapine in human plasma by a rapid and sensitive gas chromatography-nitrogen phosphorus selective detection (GN-NPD) method: validation and comparison with high-performance liquid chromatography-coulometric detection
  • Simultaneous high-performance liquid chromatographic determination of Olanzapine and Lamotrigine in plasma of bipolar patients
  • A sensitive high-performance liquid chromatographic method using electrochemical detection for the analysis of Olanzapine and desmethyl-olanzapine in plasma of schizophrenic patients using a new solid-phase extraction procedure
  • Development and validation of new RP-UPLC method for the quantitative determination of olanzapine in tablet dosage form
  • Development of a stability-indicating UPLC method for determining olanzapine and its associated degradation products present
  • Three different spectrophotometric methods manipulating ratio spectra for determination of binary mixture of amlodipine and atorvastatin
  • Smart stability-indicating spectrophotometric methods for determination of binary mixtures without prior separation
  • Spectrophotometric methods for the simultaneous determination of binary mixture of metronidazole and diloxanide furoate without prior separation
  • Novel spectrophotometric method for simultaneous determination of two binary mixtures containing hydrochlorothiazide by ratio subtraction
  • Application of smart spectrophotometric methods and artificial neural network for the simultaneous quantitation of olmesartan medoxamil, amlodipine besylate and hydrochloro-thiazide in their combined pharmaceutical dosage form
  • Absorbance subtraction and amplitude modulation as novel spectrophotometric methods for the analysis of binary mixtures
  • Comparative study of extension area based methods for spectrophotometric determination of etilefrine hydrochloride in the presence of its oxidative degradation product
  • A smart simple spectrophotometric method for simultaneous determination of binary mixtures
  • A Comparative study of the novel ratio difference method versus conventional spectrophotometric techniques for the analysis of binary mixture with overlapped spectra
  • A novel simple method for resolving overlapped spectral data with a wide range of applicability, and its application as a stability indicating method for determination of tazarotene
  • Comparative study of novel spectrophotometric methods manipulating ratio spectra: an application on pharmaceutical ternary mixture of omeprazole, tinidazole and clarithromycin
  • New simple spectrophotometric method for determination of the binary mixtures (atorvastatin calcium and ezetimibe; candesartan cilexetil and hydrochlorothiazide) in tablets