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Spectrophotometric Methods for Resolving Ternary Mixture of Diflunisal, Naproxen and Diflunisal Toxic Impurity

Spectrophotometric Methods for Resolving Ternary Mixture of Diflunisal, Naproxen and Diflunisal... AbstractTwo spectrophotometric methods have been investigated for determination of Diflunisal (DIF), Naproxen (NAP) and Diflunisal toxic impurity; Biphenyl-4-ol (BIP). Method (I) is modified ratio difference spectrophotometric method. This method can determine DIF and NAP in presence of BIP. In this method DIF has been determined by measuring the difference of amplitudes values between 250.2 and 260.4 nm in the obtained ratio spectra (using standard spectrum of 3 μg/mL of NAP as a divisor) while NAP has been determined using the difference between 216.8 and 239.8 nm (using standard spectrum of 1 μg/mL DIF as a divisor). Method (II) is multivariate calibration models including principal component regression (PCR) and partial least square (PLS), using wavelength range of 200-350 nm for both models. Regarding to the preprocessing state, non-scale was applied for PCR model while mean center of data for PLS one. The developed models were successfully applied to predict the concentration of studied components in validation set and good results were obtained. The developed methods have been successfully applied for resolving the three studied components in their ternary laboratory prepared mixtures. Also they have been used for measuring DIF and NAP in their pharmaceutical dosage form where good results were obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Spectrophotometric Methods for Resolving Ternary Mixture of Diflunisal, Naproxen and Diflunisal Toxic Impurity

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Spectrophotometric Methods for Resolving Ternary Mixture of Diflunisal, Naproxen and Diflunisal Toxic Impurity

Abstract

AbstractTwo spectrophotometric methods have been investigated for determination of Diflunisal (DIF), Naproxen (NAP) and Diflunisal toxic impurity; Biphenyl-4-ol (BIP). Method (I) is modified ratio difference spectrophotometric method. This method can determine DIF and NAP in presence of BIP. In this method DIF has been determined by measuring the difference of amplitudes values between 250.2 and 260.4 nm in the obtained ratio spectra (using standard spectrum of 3 μg/mL of NAP as a divisor)...
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Publisher
Taylor & Francis
Copyright
© 2017 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2017.1294990
Publisher site
See Article on Publisher Site

Abstract

AbstractTwo spectrophotometric methods have been investigated for determination of Diflunisal (DIF), Naproxen (NAP) and Diflunisal toxic impurity; Biphenyl-4-ol (BIP). Method (I) is modified ratio difference spectrophotometric method. This method can determine DIF and NAP in presence of BIP. In this method DIF has been determined by measuring the difference of amplitudes values between 250.2 and 260.4 nm in the obtained ratio spectra (using standard spectrum of 3 μg/mL of NAP as a divisor) while NAP has been determined using the difference between 216.8 and 239.8 nm (using standard spectrum of 1 μg/mL DIF as a divisor). Method (II) is multivariate calibration models including principal component regression (PCR) and partial least square (PLS), using wavelength range of 200-350 nm for both models. Regarding to the preprocessing state, non-scale was applied for PCR model while mean center of data for PLS one. The developed models were successfully applied to predict the concentration of studied components in validation set and good results were obtained. The developed methods have been successfully applied for resolving the three studied components in their ternary laboratory prepared mixtures. Also they have been used for measuring DIF and NAP in their pharmaceutical dosage form where good results were obtained.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Jan 2, 2017

Keywords: Diflunisal; Naproxen; Biphenyl-4-ol; Modified ratio difference; Multivariate methods

References

  • Application of derivative and derivative-ratio spectrophotometry in the determination of a binary mixture of naproxen and diflunisal and ternary mixture of orphenadrine, caffeine and aspirin
  • Simultaneous determination of the two non-steroidal anti-inflammatory drugs; diflunisal and naproxen in their tablets by chemometric Spectrometry and HPLC
  • Simultaneous determination of naproxen and diflunisal using synchronous luminescence spectrometry
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  • Validation of a liquid chromatographic method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring
  • Simultaneous determination of some multicomponent dosage forms by quantitative thin layer chromatography densitometric method
  • Development and Validation of Chromatographic Methods for Resolving Ternary Mixture of Diflunisal, Naproxen and DiflunisalToxic Impurity
  • Comparative study of novel spectrophotometric methods manipulating ratio spectra: an application on pharmaceutical ternary mixture of omeprazole, tinidazole and clarithromycin; Spectrochim
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