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Stability Indicating Assay of Florfenicol using Capillary Zone Electrophoresis in Veterinary Formulation and in Milk

Stability Indicating Assay of Florfenicol using Capillary Zone Electrophoresis in Veterinary... AbstractA simple and fast capillary zone electrophoresis method with direct ultraviolet detection has been developed for the quantitative analysis of veterinary drug florfenicol. Migration time of 1.22 minute was achieved using 1 mM borate buffer of pH 9.3 as background electrolyte. Limit of detection and limit of quantification for this method are 3.34 μg and 19.5 μg, respectively. Stability indicating assay of florfenicol is studied by exposing the drug to various stress conditions such as acidic, basic, oxidative, thermal, and ultraviolet for inducing degradation. This method was also employed for the analysis of florfenicol in its formulation and its residue in commercially available milk. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Stability Indicating Assay of Florfenicol using Capillary Zone Electrophoresis in Veterinary Formulation and in Milk

Stability Indicating Assay of Florfenicol using Capillary Zone Electrophoresis in Veterinary Formulation and in Milk

Abstract

AbstractA simple and fast capillary zone electrophoresis method with direct ultraviolet detection has been developed for the quantitative analysis of veterinary drug florfenicol. Migration time of 1.22 minute was achieved using 1 mM borate buffer of pH 9.3 as background electrolyte. Limit of detection and limit of quantification for this method are 3.34 μg and 19.5 μg, respectively. Stability indicating assay of florfenicol is studied by exposing the drug to various stress conditions...
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Publisher
Taylor & Francis
Copyright
© 2019 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2019.1595723
Publisher site
See Article on Publisher Site

Abstract

AbstractA simple and fast capillary zone electrophoresis method with direct ultraviolet detection has been developed for the quantitative analysis of veterinary drug florfenicol. Migration time of 1.22 minute was achieved using 1 mM borate buffer of pH 9.3 as background electrolyte. Limit of detection and limit of quantification for this method are 3.34 μg and 19.5 μg, respectively. Stability indicating assay of florfenicol is studied by exposing the drug to various stress conditions such as acidic, basic, oxidative, thermal, and ultraviolet for inducing degradation. This method was also employed for the analysis of florfenicol in its formulation and its residue in commercially available milk.

Journal

Analytical Chemistry LettersTaylor & Francis

Published: Mar 4, 2019

Keywords: Florfenicol; capillary electrophoresis; veterinary formulation analysis; milk analysis

References