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Stability Indicating RP-HPLC Method for Analysis ofSoy Isoflavones in Pharmaceutical Formulations

Stability Indicating RP-HPLC Method for Analysis ofSoy Isoflavones in Pharmaceutical Formulations Abstract For evaluating the stability of the Soy Isoflavones in pharmaceutical formulations and for detecting the presence of any degradation product generated during the six months of accelerated stability conditions a simple, isocratic, reverse phase HPLC method was developed for the quantification of Soy aglycones viz. Daidzein, Glycitein and Genistein. The method was found to be specific, linear (r2= 0.9994), precise (RSD for six samples < 2 %) and accurate. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Stability Indicating RP-HPLC Method for Analysis ofSoy Isoflavones in Pharmaceutical Formulations

Deshmukh, K. A.; Amin, P.D.
Analytical Chemistry Letters , Volume 2 (6): 10 – Jan 1, 2012
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Stability Indicating RP-HPLC Method for Analysis ofSoy Isoflavones in Pharmaceutical Formulations

Abstract

Abstract For evaluating the stability of the Soy Isoflavones in pharmaceutical formulations and for detecting the presence of any degradation product generated during the six months of accelerated stability conditions a simple, isocratic, reverse phase HPLC method was developed for the quantification of Soy aglycones viz. Daidzein, Glycitein and Genistein. The method was found to be specific, linear (r2= 0.9994), precise (RSD for six samples < 2 %) and accurate.
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Publisher
Taylor & Francis
Copyright
Copyright Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2012.10662617
Publisher site
See Article on Publisher Site

Abstract

Abstract For evaluating the stability of the Soy Isoflavones in pharmaceutical formulations and for detecting the presence of any degradation product generated during the six months of accelerated stability conditions a simple, isocratic, reverse phase HPLC method was developed for the quantification of Soy aglycones viz. Daidzein, Glycitein and Genistein. The method was found to be specific, linear (r2= 0.9994), precise (RSD for six samples < 2 %) and accurate.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Jan 1, 2012

Keywords: Soy Isoflavones; RP-HPLC method; Isocratic method; Acid hydrolysis

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