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Stability Indicating Spectrophotometric Methods for the Determination of Cefoxitin Sodium in Pure form and in Pharmaceutical Preparations

Stability Indicating Spectrophotometric Methods for the Determination of Cefoxitin Sodium in Pure... AbstractFour simple, accurate and precise stability-indicating spectrophotometric methods were developed and validated for the simultaneous determination of cefoxitin sodium in presence of its alkaliinduced degradation product without prior separation namely; Q-analysis, absorbance subtraction, absorbance ratio, and amplitude modulation. These methods were validated for accuracy and precision. The four proposed methods were successfully applied for the determination of the cited drug in pure form and in pharmaceutical preparation also in the presence of its alkaline degradation product. The obtained results were statistically compared with those of a reported method. The comparison showed that there are no significant differences between the proposed methods and the reported method. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Stability Indicating Spectrophotometric Methods for the Determination of Cefoxitin Sodium in Pure form and in Pharmaceutical Preparations

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Stability Indicating Spectrophotometric Methods for the Determination of Cefoxitin Sodium in Pure form and in Pharmaceutical Preparations

Abstract

AbstractFour simple, accurate and precise stability-indicating spectrophotometric methods were developed and validated for the simultaneous determination of cefoxitin sodium in presence of its alkaliinduced degradation product without prior separation namely; Q-analysis, absorbance subtraction, absorbance ratio, and amplitude modulation. These methods were validated for accuracy and precision. The four proposed methods were successfully applied for the determination of the cited drug in pure...
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Publisher
Taylor & Francis
Copyright
© 2017 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2017.1320228
Publisher site
See Article on Publisher Site

Abstract

AbstractFour simple, accurate and precise stability-indicating spectrophotometric methods were developed and validated for the simultaneous determination of cefoxitin sodium in presence of its alkaliinduced degradation product without prior separation namely; Q-analysis, absorbance subtraction, absorbance ratio, and amplitude modulation. These methods were validated for accuracy and precision. The four proposed methods were successfully applied for the determination of the cited drug in pure form and in pharmaceutical preparation also in the presence of its alkaline degradation product. The obtained results were statistically compared with those of a reported method. The comparison showed that there are no significant differences between the proposed methods and the reported method.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: May 4, 2017

Keywords: Cefoxitin sodium; stability indicating methods; Q-analysis spectrophotometric; absorbance subtraction; absorbance ratio; amplitude modulation

References

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