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Synthesis, Spectral Characterization and Antitubercular Study of Novel Quinoline Schiff Base and Its Metal Complexes

Synthesis, Spectral Characterization and Antitubercular Study of Novel Quinoline Schiff Base and... Abstract Synthesis of novel Schiff base from 2-hydroxy-6-methylquinolin-3-carbaldehyde and 4-methyl-benzenesulfonohydrazide has been carried out in the present work. Also, the metal complexes of Cu(II), Ni(II), Co(II) and Cd(II) have been synthesized. Schiff base and metal complexes were characterized by various analytical techniques such as CHN analyzer, XRD, FT-IR, UV-Visible, ESR, 1H NMR, 13C NMR, MASS and TGA. Very low value of molar conductance indicates non electrolytic nature of the complexes. The analytical data shows that the ratio of metal to ligand in Cu(II), Ni(II), Co(II) and Cd(II) complexes is 1:2. FT-IR spectral data suggest that the ligand behaves as a tridentate O, N, O donor system. Magnetic susceptibility measurements reveal the paramagnetic behavior of all the complexes except Cd-complex. Further, the Schiff base and the metal complexes were screened for their antimycobacterial activity against M. Bovis BCG and M. tuberculosis H37Ra strains. Compounds 7, 8a, 8c & 8d exhibit very promising results against M. Bovis BCG and MTB H37Ra strains. Among all, Cu-complex shows highest MIC (2.8) value. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical Chemistry Letters Taylor & Francis

Synthesis, Spectral Characterization and Antitubercular Study of Novel Quinoline Schiff Base and Its Metal Complexes

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Synthesis, Spectral Characterization and Antitubercular Study of Novel Quinoline Schiff Base and Its Metal Complexes

Abstract

Abstract Synthesis of novel Schiff base from 2-hydroxy-6-methylquinolin-3-carbaldehyde and 4-methyl-benzenesulfonohydrazide has been carried out in the present work. Also, the metal complexes of Cu(II), Ni(II), Co(II) and Cd(II) have been synthesized. Schiff base and metal complexes were characterized by various analytical techniques such as CHN analyzer, XRD, FT-IR, UV-Visible, ESR, 1H NMR, 13C NMR, MASS and TGA. Very low value of molar conductance indicates non electrolytic nature of the...
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Publisher
Taylor & Francis
Copyright
© 2021 Har Krishan Bhalla & Sons
ISSN
2230-7532
eISSN
2229-7928
DOI
10.1080/22297928.2021.1921616
Publisher site
See Article on Publisher Site

Abstract

Abstract Synthesis of novel Schiff base from 2-hydroxy-6-methylquinolin-3-carbaldehyde and 4-methyl-benzenesulfonohydrazide has been carried out in the present work. Also, the metal complexes of Cu(II), Ni(II), Co(II) and Cd(II) have been synthesized. Schiff base and metal complexes were characterized by various analytical techniques such as CHN analyzer, XRD, FT-IR, UV-Visible, ESR, 1H NMR, 13C NMR, MASS and TGA. Very low value of molar conductance indicates non electrolytic nature of the complexes. The analytical data shows that the ratio of metal to ligand in Cu(II), Ni(II), Co(II) and Cd(II) complexes is 1:2. FT-IR spectral data suggest that the ligand behaves as a tridentate O, N, O donor system. Magnetic susceptibility measurements reveal the paramagnetic behavior of all the complexes except Cd-complex. Further, the Schiff base and the metal complexes were screened for their antimycobacterial activity against M. Bovis BCG and M. tuberculosis H37Ra strains. Compounds 7, 8a, 8c & 8d exhibit very promising results against M. Bovis BCG and MTB H37Ra strains. Among all, Cu-complex shows highest MIC (2.8) value.

Journal

Analytical Chemistry Letters – Taylor & Francis

Published: Jul 4, 2021

Keywords: Schiff base; ESI MS; ESR; antimycobacterial; MIC

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