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The acetyl-CoA carboxylase enzyme: a target for cancer therapy?

The acetyl-CoA carboxylase enzyme: a target for cancer therapy? As a rate-limiting enzyme, the acetyl-CoA carboxylase (ACC) is essential for fatty acid synthesis. Traditionally, the ACC has been a target of metabolic syndrome and obesity. Recent research has demonstrated that malignant tumors have a high energy flow, thus having a great ability to synthesize fatty acids. ACCs are occasionally found to be overexpressed in cancer cells, and using chemical or RNA interference to inhibit ACC can lead to cancer cell cycle arrest and apoptosis. This suggests that ACC and relative fatty acids may be critical for the survival of cancer cells. In this review, we summarize the role of ACC in tumor development. We also discuss the signaling pathways possibly affected by ACC, which may give insight into future research for cancer therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Expert Review of Anticancer Therapy Taylor & Francis

The acetyl-CoA carboxylase enzyme: a target for cancer therapy?

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References (106)

Publisher
Taylor & Francis
Copyright
© Informa UK, Ltd.
ISSN
1744-8328
eISSN
1473-7140
DOI
10.1586/14737140.2015.1038246
pmid
25979092
Publisher site
See Article on Publisher Site

Abstract

As a rate-limiting enzyme, the acetyl-CoA carboxylase (ACC) is essential for fatty acid synthesis. Traditionally, the ACC has been a target of metabolic syndrome and obesity. Recent research has demonstrated that malignant tumors have a high energy flow, thus having a great ability to synthesize fatty acids. ACCs are occasionally found to be overexpressed in cancer cells, and using chemical or RNA interference to inhibit ACC can lead to cancer cell cycle arrest and apoptosis. This suggests that ACC and relative fatty acids may be critical for the survival of cancer cells. In this review, we summarize the role of ACC in tumor development. We also discuss the signaling pathways possibly affected by ACC, which may give insight into future research for cancer therapy.

Journal

Expert Review of Anticancer TherapyTaylor & Francis

Published: Jun 3, 2015

Keywords: acetyl-CoA carboxylase; cell cycle; cell signaling; fatty acids synthesis; tumor metabolism

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