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Wee1 kinase as a target for cancer therapy

Wee1 kinase as a target for cancer therapy Wee1, a protein kinase, regulates the G2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer. MK-1775, a selective and potent small-molecule inhibitor of wee1, is under clinical development as a potentiator of DNA damage caused by cytotoxic chemotherapies. We present a review of the role of wee1 in the cell cycle and DNA replication and summarize the clinical development to date of this novel class of anticancer agents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Cycle Taylor & Francis

Wee1 kinase as a target for cancer therapy

Cell Cycle , Volume 12 (19): 6 – Oct 1, 2013
6 pages

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Publisher
Taylor & Francis
Copyright
Copyright © 2013 Landes Bioscience
ISSN
1551-4005
eISSN
1538-4101
DOI
10.4161/cc.26062
pmid
24013427
Publisher site
See Article on Publisher Site

Abstract

Wee1, a protein kinase, regulates the G2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer. MK-1775, a selective and potent small-molecule inhibitor of wee1, is under clinical development as a potentiator of DNA damage caused by cytotoxic chemotherapies. We present a review of the role of wee1 in the cell cycle and DNA replication and summarize the clinical development to date of this novel class of anticancer agents.

Journal

Cell CycleTaylor & Francis

Published: Oct 1, 2013

Keywords: DNA damage; cell cycle; cyclin-dependent kinase; G2 checkpoint; MK 1775

There are no references for this article.