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Complement

Complement Complement is part of the innate immune system and underlies one of the main effector mechanisms of antibody-mediated immunity. It has three overarching physiologic activities (Table 1): defending against pyogenic bacterial infection, bridging innate and adaptive immunity, and disposing of immune complexes and the products of inflammatory injury. In this review, each of these activities will be placed in a clinical context. Complement was first identified as a heat-labile principle in serum that “complemented” antibodies in the killing of bacteria. We now know that complement is a system of more than 30 proteins in plasma and on cell surfaces. Complement . . . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The New England Journal of Medicine The New England Journal of Medicine

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References (45)

Publisher
The New England Journal of Medicine
Copyright
Copyright © 2001 Massachusetts Medical Society. All rights reserved.
ISSN
0028-4793
eISSN
1533-4406
DOI
10.1056/NEJM200104053441406
pmid
11287977
Publisher site
See Article on Publisher Site

Abstract

Complement is part of the innate immune system and underlies one of the main effector mechanisms of antibody-mediated immunity. It has three overarching physiologic activities (Table 1): defending against pyogenic bacterial infection, bridging innate and adaptive immunity, and disposing of immune complexes and the products of inflammatory injury. In this review, each of these activities will be placed in a clinical context. Complement was first identified as a heat-labile principle in serum that “complemented” antibodies in the killing of bacteria. We now know that complement is a system of more than 30 proteins in plasma and on cell surfaces. Complement . . .

Journal

The New England Journal of MedicineThe New England Journal of Medicine

Published: Apr 5, 2001

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