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Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa

Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa Human T-cell lymphotropic virus type I (HTLV-I)1 is the etiologic agent of adult T-cell leukemia-lymphoma.2 The serum of patients with this disease contains antibodies to HTLV-I,3 and there is monoclonal integration of HTLV-I proviruses in the malignant cells.4 The principal clinical features of adult T-cell leukemia-lymphoma5 are lymphadenopathy, hepatosplenomegaly, skin lesions, and hypercalcemia. Compromise of the immune system can allow opportunistic infection. The blood contains abnormal lymphocytes with characteristic indented or convoluted nuclei (``flower cells''). These malignant lymphocytes are activated CD4-positive T cells with increased expression of the alpha chain of the interleukin-2 receptor. Four different clinical subtypes of adult . . . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The New England Journal of Medicine The New England Journal of Medicine

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References (20)

Publisher
The New England Journal of Medicine
Copyright
Copyright © 1995 Massachusetts Medical Society. All rights reserved.
ISSN
0028-4793
eISSN
1533-4406
DOI
10.1056/NEJM199506293322604
pmid
7760891
Publisher site
See Article on Publisher Site

Abstract

Human T-cell lymphotropic virus type I (HTLV-I)1 is the etiologic agent of adult T-cell leukemia-lymphoma.2 The serum of patients with this disease contains antibodies to HTLV-I,3 and there is monoclonal integration of HTLV-I proviruses in the malignant cells.4 The principal clinical features of adult T-cell leukemia-lymphoma5 are lymphadenopathy, hepatosplenomegaly, skin lesions, and hypercalcemia. Compromise of the immune system can allow opportunistic infection. The blood contains abnormal lymphocytes with characteristic indented or convoluted nuclei (``flower cells''). These malignant lymphocytes are activated CD4-positive T cells with increased expression of the alpha chain of the interleukin-2 receptor. Four different clinical subtypes of adult . . .

Journal

The New England Journal of MedicineThe New England Journal of Medicine

Published: Jun 29, 1995

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