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A multi‐institutional comparison of outcomes of immunosuppressed and immunocompetent patients treated with surgery and radiation therapy for cutaneous squamous cell carcinoma of the head and neck

A multi‐institutional comparison of outcomes of immunosuppressed and immunocompetent patients... INTRODUCTIONApproximately 700,000 individuals are diagnosed with cutaneous squamous cell carcinoma (cSCC) in the United States annually. The overwhelming majority have excellent outcomes with single‐modality surgical clearance. However, there is a small, known subset of patients who demonstrate more aggressive behavior, including locoregional recurrence and even skin cancer‐related death. Their numbers are poorly understood because of their rarity and because skin cancer statistics are not collected by population‐based registries in the United States. Consequently, these bad actors are frequently not recognized until they present with multiply recurrent or more advanced disease. Conversely, immunosuppressed patients are a demographic in which skin cancer incidence and morbidity is known to be more common. It has been demonstrated that patients with chronic lymphoid malignancies have an 8‐fold to 13‐fold increase in the incidence of cSCC compared with the immunocompetent (IC) population, whereas organ transplant recipients (OTRs) receiving chronic immunosuppressive therapies have up to a 65‐fold to 100‐fold increase in the incidence of cSCC, with up to 50% of Caucasian OTRs developing a cutaneous neoplasm in their post‐transplantation lifetime. Although the overwhelming majority of these cancers are also easily cured with surgery alone, there is a growing body of data to suggest that high‐risk pathologic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

A multi‐institutional comparison of outcomes of immunosuppressed and immunocompetent patients treated with surgery and radiation therapy for cutaneous squamous cell carcinoma of the head and neck

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References (34)

Publisher
Wiley
Copyright
"© 2017 American Cancer Society"
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/cncr.30601
pmid
28171708
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONApproximately 700,000 individuals are diagnosed with cutaneous squamous cell carcinoma (cSCC) in the United States annually. The overwhelming majority have excellent outcomes with single‐modality surgical clearance. However, there is a small, known subset of patients who demonstrate more aggressive behavior, including locoregional recurrence and even skin cancer‐related death. Their numbers are poorly understood because of their rarity and because skin cancer statistics are not collected by population‐based registries in the United States. Consequently, these bad actors are frequently not recognized until they present with multiply recurrent or more advanced disease. Conversely, immunosuppressed patients are a demographic in which skin cancer incidence and morbidity is known to be more common. It has been demonstrated that patients with chronic lymphoid malignancies have an 8‐fold to 13‐fold increase in the incidence of cSCC compared with the immunocompetent (IC) population, whereas organ transplant recipients (OTRs) receiving chronic immunosuppressive therapies have up to a 65‐fold to 100‐fold increase in the incidence of cSCC, with up to 50% of Caucasian OTRs developing a cutaneous neoplasm in their post‐transplantation lifetime. Although the overwhelming majority of these cancers are also easily cured with surgery alone, there is a growing body of data to suggest that high‐risk pathologic

Journal

CancerWiley

Published: Jan 1, 2017

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