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An antigen specific to the liver stage of rodent malaria recognized by a monoclonal antibody

An antigen specific to the liver stage of rodent malaria recognized by a monoclonal antibody Summary Vaccines currently being evaluated against malaria are based on proteins derived from the blood, sporozoite and sexual stages. Antigens from the liver stage, which is now recognized as the major target of protective sporozoite induced immunity, have received comparatively little attention. This paper describes the generation of a monoclonal antibody (MoAb), which recognizes an antigen specific to the liver stage of the rodent malaria Plasmodium berghei. The antigen is expressed throughout liver stage development and appears to be localized to the parasitophorous vacuole membrane. The MoAb did not affect the growth of liver stages cultured in vitro nor could protection be demonstrated in vivo following passive transfer of the antibody. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Parasite Immunology Wiley

An antigen specific to the liver stage of rodent malaria recognized by a monoclonal antibody

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References (58)

Publisher
Wiley
Copyright
Copyright © 1990 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0141-9838
eISSN
1365-3024
DOI
10.1111/j.1365-3024.1990.tb00982.x
Publisher site
See Article on Publisher Site

Abstract

Summary Vaccines currently being evaluated against malaria are based on proteins derived from the blood, sporozoite and sexual stages. Antigens from the liver stage, which is now recognized as the major target of protective sporozoite induced immunity, have received comparatively little attention. This paper describes the generation of a monoclonal antibody (MoAb), which recognizes an antigen specific to the liver stage of the rodent malaria Plasmodium berghei. The antigen is expressed throughout liver stage development and appears to be localized to the parasitophorous vacuole membrane. The MoAb did not affect the growth of liver stages cultured in vitro nor could protection be demonstrated in vivo following passive transfer of the antibody.

Journal

Parasite ImmunologyWiley

Published: Sep 1, 1990

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