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M. Heneka, M. O’Banion (2007)Inflammatory processes in Alzheimer's disease
Journal of Neuroimmunology, 184
P. Mcgeer, H. Akiyama, S. Itagaki, E. Mcgeer (1989)Activation of the classical complement pathway in brain tissue of Alzheimer patients
Neuroscience Letters, 107
E. Vanmechelen, Hugo Vanderstichele, P. Davidsson, E. Kerschaver, B. Perre, Magnus Sjögren, Niels Andreasen, K. Blennow (2000)Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: a sandwich ELISA with a synthetic phosphopeptide for standardization
Neuroscience Letters, 285
J. Poirier (1994)Apolipoprotein E in animal models of CNS injury and in alzheimer's disease
Trends in Neurosciences, 17
P. Mcgeer, E. Mcgeer (2007)NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
Neurobiology of Aging, 28
Rogers (1992)Complement activation by beta-amyloid in Alzheimer disease
Proc Natl Acad Sci USA, 89
E. Rogaeva, E. Rogaeva, Y. Meng, Joseph Lee, Yongjun Gu, Yongjun Gu, T. Kawarai, T. Kawarai, F. Zou, T. Katayama, T. Katayama, C. Baldwin, R. Cheng, H. Hasegawa, H. Hasegawa, Fusheng Chen, Fusheng Chen, N. Shibata, N. Shibata, K. Lunetta, R. Pardossi-Piquard, R. Pardossi-Piquard, Christopher Bohm, Christopher Bohm, Y. Wakutani, Y. Wakutani, L. Cupples, K. Cuenco, R. Green, L. Pinessi, I. Rainero, S. Sorbi, A. Bruni, R. Duara, R. Duara, R. Friedland, R. Inzelberg, W. Hampe, H. Bujo, You-Qiang Song, O. Andersen, T. Willnow, N. Graff-Radford, R. Petersen, D. Dickson, S. Der, S. Der, P. Fraser, P. Fraser, G. Schmitt-Ulms, G. Schmitt-Ulms, S. Younkin, R. Mayeux, L. Farrer, P. George-Hyslop, P. George-Hyslop (2007)The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Nature Genetics, 39
H. Zetterberg, L. Wahlund, K. Blennow (2003)Cerebrospinal fluid markers for prediction of Alzheimer's disease
Neuroscience Letters, 352
H. Akiyama, S. Barger, S. Barnum, B. Bradt, J. Bauer, G. Cole, N. Cooper, P. Eikelenboom, M. Emmerling, B. Fiebich, C. Finch, S. Frautschy, W. Griffin, H. Hampel, M. Hull, G. Landreth, L. Lue, R. Mrak, I. Mackenzie, P. Mcgeer, M. O’Banion, J. Pachter, G. Pasinetti, C. Plata-salamán, J. Rogers, R. Rydel, Yong Shen, W. Streit, R. Strohmeyer, Ikuo Tooyoma, F. Muiswinkel, R. Veerhuis, D. Walker, S. Webster, Beatrice Wegrzyniak, G. Wenk, T. Wyss-Coray (2000)Inflammation and Alzheimer’s disease
Neurobiology of Aging, 21
P. Mcgeer, E. Mcgeer (2001)Inflammation, autotoxicity and Alzheimer disease
Neurobiology of Aging, 22
M. Watson, A. Roher, K. Kim, K. Spiegel, Mark Emmerlin (1997)Complement interactions with amyloid β1–42: A nidus for inflammation in AD brains
R. Strohmeyer, M. Ramirez, G. Cole, Kyle Mueller, J. Rogers (2002)Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in the Alzheimer's disease brain
Journal of Neuroimmunology, 131
Joseph Lee, R. Cheng, N. Schupf, J. Manly, R. Lantigua, Y. Stern, E. Rogaeva, Y. Wakutani, L. Farrer, P. George-Hyslop, R. Mayeux (2007)The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.
Archives of neurology, 64 4
L. Johnson, William Leitner, Alexander Rivest, Michelle Staples, M. Radeke, Don Anderson (2002)The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
Proceedings of the National Academy of Sciences of the United States of America, 99
L. Lau, Shih-Jen Chen, Ching-Yu Cheng, M. Yen, F. Lee, Ming-Wei Lin, W. Hsu, Yau-Huei Wei (2006)Association of the Y402H polymorphism in complement factor H gene and neovascular age-related macular degeneration in Chinese patients.
Investigative ophthalmology & visual science, 47 8
T. Clemons, Molly Rankin, W. Mcbee (2006)Cognitive impairment in the Age-Related Eye Disease Study: AREDS report no. 16.
Archives of ophthalmology, 124 4
A. Edwards, R. Ritter, K. Abel, A. Manning, Carolien Panhuysen, L. Farrer (2005)Complement Factor H Polymorphism and Age-Related Macular Degeneration
McGeer (2003)Inflammatory processes in Alzheimer's disease
Prog Neuropsychopharmacol Biol Psychiatry, 27
McKhann (1984)Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
L. Johnson, William Leitner, Alexander Rivest, Michelle Staples, M. Radeke, Don Anderson (2002)The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.
Proceedings of the National Academy of Sciences of the United States of America, 99 18
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn (1997)Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Blennow (2006)Alzheimer's disease
T. Blackmore, V. Fischetti, T. Sadlon, H. Ward, D. Gordon (1998)M Protein of the Group A StreptococcusBinds to the Seventh Short Consensus Repeat of Human Complement Factor H
Infection and Immunity, 66
G. Hageman, Don Anderson, L. Johnson, L. Hancox, Andrew Taiber, Lisa Hardisty, Jill Hageman, Heather Stockman, J. Borchardt, K. Gehrs, Richard Smith, G. Silvestri, S. Russell, C. Klaver, I. Barbazetto, Stanley Chang, L. Yannuzzi, G. Barile, J. Merriam, R. Smith, Adam Olsh, J. Bergeron, J. Zernant, J. Merriam, B. Gold, M. Dean, R. Allikmets (2005)A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.
Proceedings of the National Academy of Sciences of the United States of America, 102 20
J. Hardy, D. Selkoe (2009)The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics
L. Johnson, William Leitner, Michelle Staples, Don Anderson (2001)Complement activation and inflammatory processes in Drusen formation and age related macular degeneration.
Experimental eye research, 73 6
K. Blennow, H. Hampel (2003)CSF markers for incipient Alzheimer's disease
The Lancet Neurology, 2
G. Mckhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E. Stadlan (1984)Clinical diagnosis of Alzheimer's disease
Abdul Hye, S. Lynham, M. Thambisetty, M. Causevic, James Campbell, H. Byers, C. Hooper, F. Rijsdijk, S. Tabrizi, S. Banner, C. Shaw, C. Foy, M. Poppe, N. Archer, Gillian Hamilton, J. Powell, Richard Brown, P. Sham, M. Ward, S. Lovestone (2006)Proteome-based plasma biomarkers for Alzheimer's disease.
Brain : a journal of neurology, 129 Pt 11
P. Mcgeer, H. Akiyama, S. Itagaki, E. Mcgeer (1989)Immune System Response in Alzheimer's Disease
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 16
C. Mold, M. Kingzette, H. Gewurz (1984)C-reactive protein inhibits pneumococcal activation of the alternative pathway by increasing the interaction between factor H and C3b.
Journal of immunology, 133 2
K. Blennow, A. Ricksten, J. Prince, Anthony Brookes, T. Emahazion, C. Wasslavik, Nenad Bogdanovic, Niels Andreasen, Stellan Båtsman, Jan Marcusson, Katarina Nägga, A. Wallin, B. Regland, Hasse Olofsson, C. Hesse, P. Davidsson, L. Minthon, A. Jansson, L. Palmqvist, Lars Rymo (2000)No association between the α2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression
Journal of Neural Transmission, 107
Don Anderson, R. Mullins, G. Hageman, L. Johnson (2002)A role for local inflammation in the formation of drusen in the aging eye.
American journal of ophthalmology, 134 3
L. Johnson, S. Ozaki, Michelle Staples, P. Erickson, Don Anderson (2000)A potential role for immune complex pathogenesis in drusen formation.
Experimental eye research, 70 4
Johnson (2002)The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
Proc Natl Acad Sci USA, 99
J. Haines, M. Hauser, S. Schmidt, W. Scott, L. Olson, P. Gallins, Kylee Spencer, S. Kwan, M. Noureddine, J. Gilbert, N. Schnetz-Boutaud, A. Agarwal, E. Postel, M. Pericak-Vance (2005)Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration
J. Caprioli, F. Castelletti, Sara Bucchioni, P. Bettinaglio, E. Bresin, G. Pianetti, S. Gamba, S. Brioschi, E. Daina, G. Remuzzi, M. Noris (2003)Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease.
Human molecular genetics, 12 24
S. Webster, L. Lue, L. Brachova, A. Tenner, P. Mcgeer, K. Terai, D. Walker, B. Bradt, N. Cooper, J. Rogers (1997)Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease
Neurobiology of Aging, 18
Hageman (2005)A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
Proc Natl Acad Sci U S A, 102
Fearon (1978)Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway
Proc Natl Acad Sci USA, 75
L. Farrer, L. Cupples, J. Haines, B. Hyman, W. Kukull, R. Mayeux, R. Myers, M. Pericak-Vance, N. Risch, C. Duijn (1997)Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
JAMA, 278 16
N. Fuse, A. Miyazawa, Mingge Mengkegale, Madoka Yoshida, Ryosuke Wakusawa, T. Abe, M. Tamai (2006)Polymorphisms in Complement Factor H and Hemicentin-1 genes in a Japanese population with dry-type age-related macular degeneration.
American journal of ophthalmology, 142 6
A. Saunders, W. Strittmatter, D. Schmechel, P. George-Hyslop, M. Pericak-Vance, S. Joo, B. Rosi, J. Gusella, D. Crapper-MacLachlan, M. Alberts (1993)Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Neurology, 43 8
P. Baird, F. Islam, A. Richardson, M. Cain, N. Hunt, R. Guymer (2006)Analysis of the Y402H variant of the complement factor H gene in age-related macular degeneration.
Investigative ophthalmology & visual science, 47 10
R. Strohmeyer, Yong Shen, J. Rogers (2000)Detection of complement alternative pathway mRNA and proteins in the Alzheimer's disease brain.
Brain research. Molecular brain research, 81 1-2
J. Monfort (1993)A population-based study of dementia in 85-year-olds.
The New England journal of medicine, 329 1
C. Franceschi, M. Capri, D. Monti, S. Giunta, F. Olivieri, F. Sevini, M. Panourgia, L. Invidia, L. Celani, M. Scurti, E. Cevenini, G. Castellani, S. Salvioli (2007)Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
Mechanisms of Ageing and Development, 128
L. Bertram, R. Tanzi (2004)Alzheimer's disease: one disorder, too many genes?
Human molecular genetics, 13 Spec No 1
J. Prince, H. Zetterberg, N. Andreasen, J. Marcusson, K. Blennow (2004)APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.
Neurology, 62 11
J. Prince, H. Zetterberg, N. Andreasen, J. Marcusson, K. Blennow (2004)APOE ε4 allele is associated with reduced cerebrospinal fluid levels of Aβ42
S. Zareparsi, K. Branham, Mingyao Li, S. Shah, R. Klein, J. Ott, J. Hoh, G. Abecasis, A. Swaroop (2005)Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration.
American journal of human genetics, 77 1
C. Bengtsson, G. Blohmé, L. Hallberg, T. Hällström, B. Isaksson, K. Korsan‐Bengtsen, G. Rybo, E. Tibblin, G. Tibblin, H. Westerberg (2009)The study of women in Gothenburg 1968-1969--a population study. General design, purpose and sampling results.
Acta medica Scandinavica, 193 4
L. Grimaldi, V. Casadei, C. Ferri, F. Veglia, F. Licastro, G. Annoni, I. Biunno, G. Bellis, S. Sorbi, C. Mariani, N. Canal, W. Griffin, M. Franceschi (2000)Association of early‐onset Alzheimer's disease with an interleukin‐1α gene polymorphism
Annals of Neurology, 47
W. Griffin, J. Sheng, M. Royston, S. Gentleman, J. McKenzie, D. Graham, G. Roberts, R. Mrak (1998)Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression
Brain Pathology, 8
D. Fearon (1978)Regulation by membrane sialic acid of beta1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway.
Proceedings of the National Academy of Sciences of the United States of America, 75 4
T. Sepp, J. Khan, D. Thurlby, H. Shahid, D. Clayton, A. Moore, A. Bird, J. Yates (2006)Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers.
Investigative ophthalmology & visual science, 47 2
B. Steen (2004)Maximizing outcome of dementia treatment: the role of nutrition.
Archives of gerontology and geriatrics. Supplement, 9
R. Klein, C. Zeiss, E. Chew, J. Tsai, R. Sackler, Chad Haynes, A. Henning, J. Sangiovanni, S. Mane, S. Mayne, M. Bracken, F. Ferris, J. Ott, C. Barnstable, J. Hoh (2005)Complement Factor H Polymorphism in Age-Related Macular Degeneration
E. Giannakis, T. Jokiranta, D. Male, S. Ranganathan, R. Ormsby, V. Fischetti, C. Mold, D. Gordon (2000)A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein.
European journal of immunology, 33 4
C. Klaver, A. Ott, A. Hofman, J. Assink, M. Breteler, P. Jong (1999)Is age-related maculopathy associated with Alzheimer's Disease? The Rotterdam Study.
American journal of epidemiology, 150 9
G. Hageman, P. Luthert, N. Chong, L. Johnson, Don Anderson, R. Mullins (2001)An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration
Progress in Retinal and Eye Research, 20
F. Hulstaert, K. Blennow, A. Ivanoiu, H. Schoonderwaldt, M. Riemenschneider, P. Deyn, C. Bancher, P. Cras, J. Wiltfang, P. Mehta, Khadija Iqbal, H. Pottel, E. Vanmechelen, H. Vanderstichele (1999)Improved discrimination of AD patients using β-amyloid(1-42) and tau levels in CSF
J. Rogers, N. Cooper, S. Webster, J. Schultz, P. Mcgeer, S. Styren, W. Civin, L. Brachova, B. Bradt, P. Ward (1992)Complement activation by beta-amyloid in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America, 89 21
L. Bertram, M. McQueen, K. Mullin, D. Blacker, R. Tanzi (2007)Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Nature Genetics, 39
E. Souied, N. Leveziel, F. Richard, M. Dragon-Durey, G. Coscas, G. Soubrane, P. Benlian, V. Frémeaux-Bacchi (2005)Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population.
Molecular vision, 11
Alzheimer's disease (AD) and age‐related macular degeneration (AMD) share several epidemiological and biochemical features. The present study aimed to assess the possible influence of the AMD‐associated complement factor H (CFH) Y402H (1277T > C) polymorphism on the risk of AD. Caucasian subjects (n = 800) meeting the criteria for probable (n = 717) or definite (n = 83) AD and Caucasian non‐demented controls (n = 1265) were included in this multi‐center case‐control study, in which genotype and allele frequencies of the CFH 1277T > C polymorphism were determined and related to diagnosis, APOE genotype, Mini‐Mental State Examination score (MMSE) and the cerebrospinal fluid (CSF) biomarkers total‐tau (T‐tau), phospho‐tau181 (P‐tau181), and β‐amyloid1–42 (Aβ1–42). The AMD‐associated CFH genotypes (1277CC and 1277TC) were overrepresented in subjects with AD as compared to control individuals (P = 0.029). Positive C carrier status was associated with an odds ratio (OR) for AD of 1.24 (95% confidence interval (CI) 1.02–1.50). When APOE ε4 carrier status was included in the regression model, this association was even stronger (OR 1.34, 95% CI: 1.08–1.65, P = 0.007). Subgroup analysis showed that the association between CFH C allele positivity and AD was only evident for individuals carrying the APOE ε4 allele. Positive C carrier status was also associated with lower levels of CSF Aβ1–42 selectively in the control group in an APOE ε4‐independent manner (P = 0.003). In conclusion, the CFH 1277T > C polymorphism seems to influence the risk of AD and there appears to be an interaction between CFH 1277C and APOE ε4 alleles. The CFH 1277C allele may predispose patients for co‐morbidity in AD and AMD. © 2007 Wiley‐Liss, Inc.
American Journal of Medical Genetics part B – Wiley
Published: Sep 5, 2008
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