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R. Cantor, N. Kono, J. Duvall, A. Alvarez-Retuerto, J. Stone, M. Alarcón, S. Nelson, D. Geschwind (2005)Replication of autism linkage: fine-mapping peak at 17q21.
American journal of human genetics, 76 6
Xingguang Luo, T. Klempan, J. Lappalainen, R. Rosenheck, D. Charney, J. Erdos, D. Kammen, H. Kranzler, J. Kennedy, J. Gelernter (2004)NOTCH4 gene haplotype is associated with schizophrenia in African Americans
Biological Psychiatry, 55
(2000)Practice parameter: Screening and diagnosis of autism: Report of the Quality Standards Subcommittee
N. Risch, E. Burchard, E. Ziv, Hua Tang (2002)Categorization of humans in biomedical research: genes, race and disease
Genome Biology, 3
C. Lord, M. Rutter, A. Couteur (1994)Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders
Journal of Autism and Developmental Disorders, 24
A. Collins, D. Ma, P. Whitehead, E. Martin, H. Wright, R. Abramson, J. Hussman, J. Haines, M. Cuccaro, J. Gilbert, M. Pericak-Vance (2006)Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
Andrew Skol, K. Young, D. Tsuang, S. Faraone, S. Faraone, S. Haverstock, S. Bingham, S. Prabhudesai, F. Mena, A. Menon, Chang-En Yu, P. Rundell, J. Pepple, J. Pepple, F. Sauter, C. Baldwin, D. Weiss, J. Collins, T. Keith, M. Boehnke, G. Schellenberg, M. Tsuang, M. Tsuang (2003)Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 118B
L. Hudgins, J. Geer, S. Cassidy (1998)Phenotypic differences in African Americans with Prader-Willi syndrome
Genetics in Medicine, 1
T. Dyches, Lynn Wilder, R. Sudweeks, F. Obiakor, B. Algozzine (2004)Multicultural Issues in Autism
Journal of Autism and Developmental Disorders, 34
H. Coon (2006)Current perspectives on the genetic analysis of autism
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 142C
N. Ramoz, J. Reichert, Thomas Corwin, Christopher Smith, J. Silverman, E. Hollander, J. Buxbaum (2006)Lack of Evidence for Association of the Serotonin Transporter Gene SLC6A4 with Autism
Biological Psychiatry, 60
M. Yeargin-Allsopp, C. Rice, Tanya Karapurkar, N. Doernberg, C. Boyle, C. Murphy (2003)Prevalence of autism in a US metropolitan area.
JAMA, 289 1
A. Reiner, E. Ziv, D. Lind, C. Nievergelt, N. Schork, S. Cummings, Angie Phong, E. Burchard, T. Harris, B. Psaty, P. Kwok (2005)Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study.
American journal of human genetics, 76 3
D. Mandell, J. Listerud, S. Levy, J. Pinto-Martin (2002)Race differences in the age at diagnosis among medicaid-eligible children with autism.
Journal of the American Academy of Child and Adolescent Psychiatry, 41 12
(1999)Autism Diagnostic Observation Schedule-WPS (WPS Edition)
L. Hudgins, J. Geer, S. Cassidy (1998)Phenotypic differerencss in African Americans with Prader-Willi syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics, 1 1
S. Santangelo, K. Tsatsanis (2005)What is known about autism: genes, brain, and behavior.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 5 2
H. Tager-Flusberg, R. Joseph (2003)Identifying neurocognitive phenotypes in autism.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 358 1430
(2003)2003.AutismDiagnostic Interview, Revised (ADI-R)
R. Rabionet, J. McCauley, J. Jaworski, A. Ashley-Koch, E. Martin, J. Sutcliffe, J. Haines, G. Delong, R. Abramson, H. Wright, M. Cuccaro, J. Gilbert, M. Pericak-Vance (2006)Lack of association between autism and SLC25A12.
The American journal of psychiatry, 163 5
R. Hu (2003)Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
C. Lord, A. Pickles, J. McLennan, M. Rutter, J. Bregman, Susan Folstein, E. Fombonne, M. Leboyer, N. Minshew (1997)Diagnosing Autism: Analyses of Data from the Autism Diagnostic Interview
Journal of Autism and Developmental Disorders, 27
J. Almirall, T. López (2002)Spironolactone and ACE inhibition in chronic renal failure.
The New England journal of medicine, 346 6
D. Mandell, M. Novak, Cynthia Zubritsky (2005)Factors Associated With Age of Diagnosis Among Children With Autism Spectrum Disorders
A. Epstein (2002)Volume and outcome--it is time to move ahead.
The New England journal of medicine, 346 15
R. Hillman, N. Kanafani, T. Takahashi, J. Miles (2000)Prevalence of autism in Missouri: changing trends and the effect of a comprehensive state autism project.
Missouri medicine, 97 5
T. Campbell, C. Dollaghan, H. Rockette, J. Paradise, H. Feldman, L. Shriberg, D. Sabo, M. Kurs‐Lasky (2003)Risk factors for speech delay of unknown origin in 3-year-old children.
Child development, 74 2
E. Fombonne (2003)Epidemiological Surveys of Autism and Other Pervasive Developmental Disorders: An Update
Journal of Autism and Developmental Disorders, 33
(2003)and the Child Neurology Society
L. Croen, J. Grether, S. Selvin (2002)Descriptive Epidemiology of Autism in a California Population: Who Is at Risk?
Journal of Autism and Developmental Disorders, 32
J. Roberts, M. Burchinal, M. Durham (1999)Parents' report of vocabulary and grammatical development of African American preschoolers: child and environmental associations.
Child development, 70 1
M. Alarcón, Amanda Yonan, T. Gilliam, R. Cantor, D. Geschwind (2005)Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs
Molecular Psychiatry, 10
P. Desai, H. Hendrie, R. Evans, J. Murrell, S. DeKosky, M. Kamboh (2003)Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African‐Americans
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 116B
S. Santangelo, K. Tsatsanis (2005)What is Known About Autism
American Journal of Pharmacogenomics, 5
D. Mandell, M. Novak (2005)The role of culture in families' treatment decisions for children with autism spectrum disorders.
Mental retardation and developmental disabilities research reviews, 11 2
T. Rebbeck (2005)Genetics, disparities, and prostate cancer.
LDI issue brief, 10 7
E. Hoff (2003)The specificity of environmental influence: socioeconomic status affects early vocabulary development via maternal speech.
Child development, 74 5
E. Hoff-Ginsberg (1991)Mother-child conversation in different social classes and communicative settings.
Child development, 62 4
Unlike other complex diseases, the study of autism has been almost exclusively limited to Caucasian families. This study represents a first effort to examine clinical and phenotypic findings in individuals with autism from African American families. Drawing from an ongoing genetic study of autism we compared African American (N = 46, mean age = 118 months) and Caucasian (N = 298, mean age = 105 months) groups on autism symptoms and developmental language symptoms. The African American group showed greater delays in language but did not differ from the Caucasian group on core autism symptoms. These findings, while suggestive of a more severe phenotype, may reflect an ascertainment bias. Nonetheless, we believe that more studies of racial‐ethnic groups should be conducted with several goals in mind including strengthening recruiting strategies to include more ethnic‐racial groups and more thoughtful evaluation of phenotypic traits. Such considerations will aid greatly in the search for genetic variants in autism. © 2007 Wiley‐Liss, Inc.
American Journal of Medical Genetics part B – Wiley
Published: Dec 5, 2007
Keywords: autism; phenotype; African American; racial‐ethnic; genetics
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