Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Case–Control Study of Maternal Residential Atrazine Exposure and Male Genital Malformations

Case–Control Study of Maternal Residential Atrazine Exposure and Male Genital Malformations Exposure to endocrine disrupting chemicals has been associated with risk for male genital malformations. However, residential prenatal exposure to atrazine, an endocrine disrupting pesticide, has not been evaluated. We obtained data from the Texas Birth Defects Registry for 16,433 cases with isolated male genital malformations and randomly selected, population‐based controls delivered during 1999–2008. County‐level estimates of atrazine exposure from the United States Geological Survey were linked to all subjects. We evaluated the relationship between estimated maternal residential atrazine exposure and risk for male genital malformations in offspring. Separate unconditional logistic regression analyses were conducted for hypospadias, cryptorchidism, and small penis. We observed modest, but consistent, associations between medium‐low and/or medium levels of estimated periconceptional maternal residential atrazine exposure and every male genital malformation category evaluated (e.g., adjusted odds ratio for medium compared to low atrazine levels and all male genital malformations: 1.2, 95% confidence interval: 1.1–1.3). Previous literature from animal and epidemiological studies supports our findings. Our results provide further evidence of a suspected teratogenic role of atrazine. © 2013 Wiley Periodicals, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Part A Wiley

Case–Control Study of Maternal Residential Atrazine Exposure and Male Genital Malformations

Loading next page...
 
/lp/wiley/case-control-study-of-maternal-residential-atrazine-exposure-and-male-hH0EVENBM3

References (24)

Publisher
Wiley
Copyright
Copyright © 2012 Wiley Periodicals, Inc.
ISSN
1552-4825
eISSN
1552-4833
DOI
10.1002/ajmg.a.35815
pmid
23494929
Publisher site
See Article on Publisher Site

Abstract

Exposure to endocrine disrupting chemicals has been associated with risk for male genital malformations. However, residential prenatal exposure to atrazine, an endocrine disrupting pesticide, has not been evaluated. We obtained data from the Texas Birth Defects Registry for 16,433 cases with isolated male genital malformations and randomly selected, population‐based controls delivered during 1999–2008. County‐level estimates of atrazine exposure from the United States Geological Survey were linked to all subjects. We evaluated the relationship between estimated maternal residential atrazine exposure and risk for male genital malformations in offspring. Separate unconditional logistic regression analyses were conducted for hypospadias, cryptorchidism, and small penis. We observed modest, but consistent, associations between medium‐low and/or medium levels of estimated periconceptional maternal residential atrazine exposure and every male genital malformation category evaluated (e.g., adjusted odds ratio for medium compared to low atrazine levels and all male genital malformations: 1.2, 95% confidence interval: 1.1–1.3). Previous literature from animal and epidemiological studies supports our findings. Our results provide further evidence of a suspected teratogenic role of atrazine. © 2013 Wiley Periodicals, Inc.

Journal

American Journal of Medical Genetics Part AWiley

Published: May 1, 2013

Keywords: ; ; ; ;

There are no references for this article.