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circCIMT Silencing Promotes Cadmium‐Induced Malignant Transformation of Lung Epithelial Cells Through the DNA Base Excision Repair Pathway (Adv. Sci. 14/2023)

circCIMT Silencing Promotes Cadmium‐Induced Malignant Transformation of Lung Epithelial Cells... Malignant transforMtion of Cells a Cadmium (Cd) exposure derived from air pollution and smoking may cause lung cancer. In article number 2206896, Lihua Huang, Yiguo Jiang, and co-workers reveal the mechanism of the role of circRNA in DNA damage and repair during Cd-induced transformation of lung epithelial cell. Cd affects the binding of circCIMT and APEX1 protein, which further inhibited DNA base excision repair, resulting in DNA damage accumulation and promoting lung cancer occurrence. These findings provide significant insights into the importance of genetic- epigenetic interactions upon chemical-induced carcinogenesis in human. www.advancedscience.com http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Science Wiley

circCIMT Silencing Promotes Cadmium‐Induced Malignant Transformation of Lung Epithelial Cells Through the DNA Base Excision Repair Pathway (Adv. Sci. 14/2023)

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Publisher
Wiley
Copyright
© 2023 Wiley‐VCH GmbH
eISSN
2198-3844
DOI
10.1002/advs.202370086
Publisher site
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Abstract

Malignant transforMtion of Cells a Cadmium (Cd) exposure derived from air pollution and smoking may cause lung cancer. In article number 2206896, Lihua Huang, Yiguo Jiang, and co-workers reveal the mechanism of the role of circRNA in DNA damage and repair during Cd-induced transformation of lung epithelial cell. Cd affects the binding of circCIMT and APEX1 protein, which further inhibited DNA base excision repair, resulting in DNA damage accumulation and promoting lung cancer occurrence. These findings provide significant insights into the importance of genetic- epigenetic interactions upon chemical-induced carcinogenesis in human. www.advancedscience.com

Journal

Advanced Science – Wiley

Published: May 1, 2023

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