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Commentary on “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 neuroinvasion”

Commentary on “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2... This commentary highlights and discusses the significance and contributions of the article titled “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 neuroinvasion” by Balasubramanian et al. The manuscript suggests that alcohol use disorder (AUD) affects the expression of angiotensin‐converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in neural circuits and other entry points, referred to as neuroinvasion, of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). SARS‐CoV‐2 receptors, ACE2 and TMPRSS2 are upregulated in the brains of alcohol‐dependent people. ACE2 and TMPRSS2 are responsible for receptor‐mediated endocytosis of SARS‐CoV‐2. SARS‐CoV‐2 internalization is linked to alcohol‐related pathophysiology, specifically the renin‐angiotensin system (RAS). This study suggests some potential mechanisms underlying SARS‐CoV‐2's entry into the central nervous system (CNS) and increased vulnerability to cardiovascular, respiratory, and neuropsychiatric complications.The authors exposed C57BL/6J (B6) mice to chronic intermittent ethanol (CIE) vapor for 4 weeks to examine the immunofluorescence of ACE2; western blot of TMPRSS2, Cathepsin L (CTSL) and A disintegrin and metalloprotease 17 (ADAM17); and RT‐qPCR of RAS pathway regulators and inflammatory markers. Following CIE, ACE2 expression is increased in the olfactory bulb (OB), hypothalamus (HT), raphe magnus (RMG), raphe obscurus (ROB), locus coeruleus (LC), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcoholism Wiley

Commentary on “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 neuroinvasion”

Chang, Sulie L.; Zhang, Jonathan
Alcoholism , Volume Early View – May 26, 2023
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References (20)

Publisher
Wiley
Copyright
© 2023 by the Research Society on Alcoholism
ISSN
0145-6008
eISSN
1530-0277
DOI
10.1111/acer.15122
Publisher site
See Article on Publisher Site

Abstract

This commentary highlights and discusses the significance and contributions of the article titled “Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 neuroinvasion” by Balasubramanian et al. The manuscript suggests that alcohol use disorder (AUD) affects the expression of angiotensin‐converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in neural circuits and other entry points, referred to as neuroinvasion, of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). SARS‐CoV‐2 receptors, ACE2 and TMPRSS2 are upregulated in the brains of alcohol‐dependent people. ACE2 and TMPRSS2 are responsible for receptor‐mediated endocytosis of SARS‐CoV‐2. SARS‐CoV‐2 internalization is linked to alcohol‐related pathophysiology, specifically the renin‐angiotensin system (RAS). This study suggests some potential mechanisms underlying SARS‐CoV‐2's entry into the central nervous system (CNS) and increased vulnerability to cardiovascular, respiratory, and neuropsychiatric complications.The authors exposed C57BL/6J (B6) mice to chronic intermittent ethanol (CIE) vapor for 4 weeks to examine the immunofluorescence of ACE2; western blot of TMPRSS2, Cathepsin L (CTSL) and A disintegrin and metalloprotease 17 (ADAM17); and RT‐qPCR of RAS pathway regulators and inflammatory markers. Following CIE, ACE2 expression is increased in the olfactory bulb (OB), hypothalamus (HT), raphe magnus (RMG), raphe obscurus (ROB), locus coeruleus (LC),

Journal

Alcoholism – Wiley

Published: May 26, 2023

Keywords: alcohol consumption; blood–brain barrier (BBB); gut microbiome; ingenuity pathway analysis (IPA); Qiagen Knowledge Base (QKB)

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