Get 20M+ Full-Text Papers For Less Than $1.50/day. Subscribe now for You or Your Team.

Learn More →

Death‐associated protein kinase (DAPK) and signal transduction: regulation in cancer

Death‐associated protein kinase (DAPK) and signal transduction: regulation in cancer Death‐associated protein kinase (DAPK) is a pro‐apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post‐translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Febs Journal Wiley

Death‐associated protein kinase (DAPK) and signal transduction: regulation in cancer

Loading next page...
 
/lp/wiley/death-associated-protein-kinase-dapk-and-signal-transduction-yPK27tZ3rm

References (53)

Publisher
Wiley
Copyright
© 2009 The Authors Journal compilation © 2009 FEBS
ISSN
1742-464X
eISSN
1742-4658
DOI
10.1111/j.1742-4658.2009.07414.x
pmid
19878310
Publisher site
See Article on Publisher Site

Abstract

Death‐associated protein kinase (DAPK) is a pro‐apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post‐translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK.

Journal

Febs JournalWiley

Published: Jan 1, 2010

There are no references for this article.