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Detection of human herpesvirus 8 DNA in serum from blood donors with HHV‐8 antibodies indicates possible bloodborne virus transmission

Detection of human herpesvirus 8 DNA in serum from blood donors with HHV‐8 antibodies indicates... Human herpesvirus 8 (HHV‐8) is associated with Kaposi's sarcoma. There is a high seroprevalence of HHV‐8 in several African countries, but the transmission route is not known definitively. In this study 174 serum samples from blood donors in Tanzania were examined by immunofluorescence assays detecting antibodies to latent and lytic HHV‐8 antigens. Real‐time polymerase chain reaction was used for detection and quantification of HHV‐8 DNA in serum. In all, 83/174 (48%) of the subjects had antibodies to latent or lytic antigens. Forty (23%) had antibodies to both antigens and of those eight (20%) had detectable HHV‐8 DNA in serum. HHV‐8 DNA load correlated with antibody titres to lytic, but not latent, HHV‐8 antigens. This supports the usefulness of anti‐lytic antibodies in HHV‐8 serology and suggests that transmission of HHV‐8 by blood contact could be of importance in this region. J. Med. Virol. 68: 264–267, 2002. © 2002 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

Detection of human herpesvirus 8 DNA in serum from blood donors with HHV‐8 antibodies indicates possible bloodborne virus transmission

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References (30)

Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services
ISSN
0146-6615
eISSN
1096-9071
DOI
10.1002/jmv.10183
pmid
12210417
Publisher site
See Article on Publisher Site

Abstract

Human herpesvirus 8 (HHV‐8) is associated with Kaposi's sarcoma. There is a high seroprevalence of HHV‐8 in several African countries, but the transmission route is not known definitively. In this study 174 serum samples from blood donors in Tanzania were examined by immunofluorescence assays detecting antibodies to latent and lytic HHV‐8 antigens. Real‐time polymerase chain reaction was used for detection and quantification of HHV‐8 DNA in serum. In all, 83/174 (48%) of the subjects had antibodies to latent or lytic antigens. Forty (23%) had antibodies to both antigens and of those eight (20%) had detectable HHV‐8 DNA in serum. HHV‐8 DNA load correlated with antibody titres to lytic, but not latent, HHV‐8 antigens. This supports the usefulness of anti‐lytic antibodies in HHV‐8 serology and suggests that transmission of HHV‐8 by blood contact could be of importance in this region. J. Med. Virol. 68: 264–267, 2002. © 2002 Wiley‐Liss, Inc.

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2002

Keywords: ; ;

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