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Effect of near‐infrared laser treatment on improving erectile function in rats with diabetes mellitus

Effect of near‐infrared laser treatment on improving erectile function in rats with diabetes... INTRODUCTIONErectile dysfunction (ED) is common worldwide.1 Although phosphodiesterase type‐5 inhibitors (PDE5i) remain the first‐line treatment for ED, their efficacy is much lower in patients with diabetes mellitus‐induced erectile dysfunction (DMED).2–4 A safe, effective, economical, and convenient treatment would be the ideal choice for the treatment of DMED.DMED treatment difficulties are primarily because of the tissues of the corpus cavernosum (CC) (i.e., smooth muscle, endothelium, and nerve) being injured by diabetes mellitus (DM) and oxidative stress (OS) accounts for the principal pathway of injury.5,6 Although there are numerous studies on treatments targeting OS in an attempt to improve erectile function in DM rats, the majority of these studies focused on drugs used or specific proteins.7–9Mitochondria are the primary source of OS.10 Through photobiomodulation (PBM) effect, near‐infrared (NIR) laser can activate mitochondria and elicit anti‐OS actions.11,12 NIR transcranial photobiomodulation (NIR‐tPBM) has been adopted as a novel treatment for multiple neurological and psychological disorders, such as traumatic brain injury, Alzheimer's disease, Parkinson's disease, anxiety, and depression, because of its anti‐OS function.12–16 Therefore, ascertaining whether NIR might improve erectile function in DMED rats through its anti‐OS properties has scientific significance.In this study, we exploited streptozotocin (STZ)‐induced DM rat as our animal model. We http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Andrology Wiley

Effect of near‐infrared laser treatment on improving erectile function in rats with diabetes mellitus

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Publisher
Wiley
Copyright
© 2023 American Society of Andrology and European Academy of Andrology.
ISSN
2047-2919
eISSN
2047-2927
DOI
10.1111/andr.13422
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONErectile dysfunction (ED) is common worldwide.1 Although phosphodiesterase type‐5 inhibitors (PDE5i) remain the first‐line treatment for ED, their efficacy is much lower in patients with diabetes mellitus‐induced erectile dysfunction (DMED).2–4 A safe, effective, economical, and convenient treatment would be the ideal choice for the treatment of DMED.DMED treatment difficulties are primarily because of the tissues of the corpus cavernosum (CC) (i.e., smooth muscle, endothelium, and nerve) being injured by diabetes mellitus (DM) and oxidative stress (OS) accounts for the principal pathway of injury.5,6 Although there are numerous studies on treatments targeting OS in an attempt to improve erectile function in DM rats, the majority of these studies focused on drugs used or specific proteins.7–9Mitochondria are the primary source of OS.10 Through photobiomodulation (PBM) effect, near‐infrared (NIR) laser can activate mitochondria and elicit anti‐OS actions.11,12 NIR transcranial photobiomodulation (NIR‐tPBM) has been adopted as a novel treatment for multiple neurological and psychological disorders, such as traumatic brain injury, Alzheimer's disease, Parkinson's disease, anxiety, and depression, because of its anti‐OS function.12–16 Therefore, ascertaining whether NIR might improve erectile function in DMED rats through its anti‐OS properties has scientific significance.In this study, we exploited streptozotocin (STZ)‐induced DM rat as our animal model. We

Journal

Andrology – Wiley

Published: Mar 4, 2023

Keywords: diabetes mellitus; erectile dysfunction; near‐infrared laser therapy; oxidative stress; photobiomodulation; rats

References

  • Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus
    Vickers, MA; Satyanarayana, R
  • Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database
    Penson, DF; Latini, DM; Lubeck, DP; Wallace, KL; Henning, JM; Lue, TF
  • Low‐intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta‐analysis
    Lu, Z; Lin, G; Reed‐Maldonado, A; Wang, C; Lee, YC; Lue, TF
  • The role of free radical in the pathogenesis of impotence in streptozotocin‐induced diabetic rats
    Ryu, JK; Kim, DJ; Lee, T; Kang, YS; Yoon, SM; Suh, JK
  • TNF‐α, erectile dysfunction, and NADPH oxidase‐mediated ROS generation in corpus cavernosum in high‐fat diet/streptozotocin‐induced diabetic rats
    Long, T; Liu, G; Wang, Y; Chen, Y; Zhang, Y; Qin, D
  • Cysteine‐rich whey protein isolate (CR‐WPI) ameliorates erectile dysfunction by diminishing oxidative stress via DDAH/ADMA/NOS pathway
    Li, K; Zhu, A; Gutman, J; Fu, Q; Liu, S
  • N‐acetylcysteine improves diabetic associated erectile dysfunction in streptozotocin‐induced diabetic mice by inhibiting oxidative stress
    Ma, Z; Wang, W; Pan, C
  • The near‐infrared dye IR‐61 restores erectile function in a streptozotocin‐induced diabetes model via mitochondrial protection
    Yue, XF; Shen, CX; Wang, JW
  • Mitochondria in health and disease
    Annesley, SJ; Fisher, PR
  • Mitochondrial signaling in mammalian cells activated by red and near‐IR radiation
    Karu, TI
  • Mechanisms and mitochondrial redox signaling in photobiomodulation
    Hamblin, MR
  • Shining light on the head: photobiomodulation for brain disorders
    Hamblin, MR
  • Photobiomodulation and the brain: a new paradigm
    Hennessy, M; Hamblin, MR
  • Transcranial low‐level laser (light) therapy for brain injury
    Thunshelle, C; Hamblin, MR
  • Brain photobiomodulation therapy: a narrative review
    Salehpour, F; Mahmoudi, J; Kamari, F; Sadigh‐Eteghad, S; Rasta, SH; Hamblin, MR
  • Biphasic dose response in low level light therapy
    Huang, YY; Chen, AC; Carroll, JD; Hamblin, MR
  • Biphasic dose response in low level light therapy—an update
    Huang, YY; Sharma, SK; Carroll, J; Hamblin, MR
  • Proposed mechanisms of photobiomodulation or low‐level light therapy
    Freitas, LF; Hamblin, MR
  • Cell biology: power games
    Lane, N
  • Low‐level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3K/Akt signaling pathway
    Li, Y; Xu, Q; Shi, M
  • Effects of low‐energy shockwave therapy on the erectile function and tissue of a diabetic rat model
    Qiu, X; Lin, G; Xin, Z
  • Recruitment of intracavernously injected adipose‐derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury
    Fandel, TM; Albersen, M; Lin, G
  • Imbalance between matrix metalloproteinase‐1 (MMP‐1) and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) contributes to bladder compliance changes in rabbits with partial bladder outlet obstruction
    Yang, L; Liu, R; Wang, X; He, D
  • The effect of laser beams on the growth of hair in mice
    Mester, E; Szende, B; Gärtner, P
  • Laser stimulation of wound healing
    Mester, E; Nagylucskay, A; Döklen, A; Tisza, S
  • Erectile dysfunction
    Shamloul, R; Ghanem, H