Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature

Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation,... Background. Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth. Methods. The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis. Results. HBO2 treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected. Conclusions. This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Head & Neck: Journal for the Sciences & Specialties of the Head and Neck Wiley

Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature

Loading next page...
 
/lp/wiley/effects-of-hyperbaric-oxygen-exposure-on-experimental-head-and-neck-Ee3dYh0SBb

References (32)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Periodicals, Inc.
ISSN
1043-3074
eISSN
1097-0347
DOI
10.1002/hed.20169
pmid
15818558
Publisher site
See Article on Publisher Site

Abstract

Background. Hyperbaric oxygen (HBO2) is used to promote healing in irradiated tissues, but concern persists about the possibility that it may promote residual tumor growth. Methods. The tumor growth of SQ20B and Detroit 562 head and neck squamous cell carcinoma xenografts were studied after single‐dose irradiation and 5×/week HBO2 treatment at 2.4 atm absolute for 90 minutes. The effect of HBO2 treatment on tumor hypoxia and vasculature was also examined by immunohistochemical analysis. Results. HBO2 treatment increased tumor oxygenation during the treatment interval but did not promote the growth of either irradiated or unirradiated tumors. No increase in tumor vascular endothelial growth factor expression or vascularization was detected. Conclusions. This study found no evidence for persistent changes in tumor microenvironment or tumor growth promotion caused by hyperbaric oxygen exposure. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005

Journal

Head & Neck: Journal for the Sciences & Specialties of the Head and NeckWiley

Published: May 1, 2005

There are no references for this article.