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Effects of interleukin‐10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects

Effects of interleukin‐10 gene polymorphism on the development of gastric cancer and peptic ulcer... Background: Anti‐inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti‐inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the IL‐10 polymorphism, one of the representative anti‐inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan. Methods: The IL‐10‐1082 (A/G)/‐819 (T/C)/‐592 (A/C) polymorphisms were assessed in Helicobacter pylori‐positive patients with gastritis only (n = 162), gastric ulcers (n = 110), duodenal ulcers (n = 94), or gastric cancers (n = 105), and H. pylori‐negative controls (n = 168) by allele specific primer–polymerase chain reaction methods. Results: The carriage of IL‐10‐592 C (age and sex‐adjusted odds ratio (OR): 1.851, 95% confidence interval (CI): 1.018–3.380) and IL‐10‐819 C (adjusted OR: 1.868, 95%CI: 1.023–3.411) allele were associated with an increased risk for gastric cancer development, not gastric ulcer and duodenal ulcer. The IL‐10‐1082 polymorphism had no association with development of gastric cancer and peptic ulcers. The presence of the ATA/GCC haplotype of IL‐10‐1082/‐819/‐592 polymorphism significantly increased the risk of gastric cancer development (adjusted OR: 2.805, 95%CI: 1.258–6.254) compared with presence of the ATA/ATA haplotype. Conclusions: The IL‐10‐1082/‐819/‐592 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan. The genotyping test of this anti‐inflammatory cytokine would be useful for the detection of individuals with higher risk of gastric cancer development. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Gastroenterology and Hepatology Wiley

Effects of interleukin‐10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects

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References (46)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0815-9319
eISSN
1440-1746
DOI
10.1111/j.1440-1746.2006.04613.x
pmid
17716348
Publisher site
See Article on Publisher Site

Abstract

Background: Anti‐inflammatory cytokines play an important role in downregulation of inflammation and the prevention of neoplastic disorders. Genetic variations of anti‐inflammatory cytokines are assumed to influence such responses. The aim of the present study was to clarify the association between the IL‐10 polymorphism, one of the representative anti‐inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan. Methods: The IL‐10‐1082 (A/G)/‐819 (T/C)/‐592 (A/C) polymorphisms were assessed in Helicobacter pylori‐positive patients with gastritis only (n = 162), gastric ulcers (n = 110), duodenal ulcers (n = 94), or gastric cancers (n = 105), and H. pylori‐negative controls (n = 168) by allele specific primer–polymerase chain reaction methods. Results: The carriage of IL‐10‐592 C (age and sex‐adjusted odds ratio (OR): 1.851, 95% confidence interval (CI): 1.018–3.380) and IL‐10‐819 C (adjusted OR: 1.868, 95%CI: 1.023–3.411) allele were associated with an increased risk for gastric cancer development, not gastric ulcer and duodenal ulcer. The IL‐10‐1082 polymorphism had no association with development of gastric cancer and peptic ulcers. The presence of the ATA/GCC haplotype of IL‐10‐1082/‐819/‐592 polymorphism significantly increased the risk of gastric cancer development (adjusted OR: 2.805, 95%CI: 1.258–6.254) compared with presence of the ATA/ATA haplotype. Conclusions: The IL‐10‐1082/‐819/‐592 genotype status and haplotype were associated with an increased risk for gastric cancer development, not peptic ulcer, in Japan. The genotyping test of this anti‐inflammatory cytokine would be useful for the detection of individuals with higher risk of gastric cancer development.

Journal

Journal of Gastroenterology and HepatologyWiley

Published: Sep 1, 2007

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