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Engineering Tough, Injectable, Naturally Derived, Bioadhesive Composite Hydrogels

Engineering Tough, Injectable, Naturally Derived, Bioadhesive Composite Hydrogels Engineering mechanically robust bioadhesive hydrogels that can withstand large strains may open new opportunities for the sutureless sealing of highly stretchable tissues. While typical chemical modifications of hydrogels, such as increasing the functional group density of crosslinkable moieties and blending them with other polymers or nanomaterials have resulted in improved mechanical stiffness, the modified hydrogels have often exhibited increased brittleness resulting in deteriorated sealing capabilities under large strains. Furthermore, highly elastic hydrogels, such as tropoelastin derivatives are highly expensive. Here, gelatin methacryloyl (GelMA) is hybridized with methacrylate‐modified alginate (AlgMA) to enable ion‐induced reversible crosslinking that can dissipate energy under strain. The hybrid hydrogels provide a photocrosslinkable, injectable, and bioadhesive platform with an excellent toughness that can be tailored using divalent cations, such as calcium. This class of hybrid biopolymers with more than 600% improved toughness compared to GelMA may set the stage for durable, mechanically resilient, and cost‐effective tissue sealants. This strategy to increase the toughness of hydrogels may be extended to other crosslinkable polymers with similarly reactive moieties. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Healthcare Materials Wiley

Engineering Tough, Injectable, Naturally Derived, Bioadhesive Composite Hydrogels

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References (57)

Publisher
Wiley
Copyright
© 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2192-2640
eISSN
2192-2659
DOI
10.1002/adhm.201901722
Publisher site
See Article on Publisher Site

Abstract

Engineering mechanically robust bioadhesive hydrogels that can withstand large strains may open new opportunities for the sutureless sealing of highly stretchable tissues. While typical chemical modifications of hydrogels, such as increasing the functional group density of crosslinkable moieties and blending them with other polymers or nanomaterials have resulted in improved mechanical stiffness, the modified hydrogels have often exhibited increased brittleness resulting in deteriorated sealing capabilities under large strains. Furthermore, highly elastic hydrogels, such as tropoelastin derivatives are highly expensive. Here, gelatin methacryloyl (GelMA) is hybridized with methacrylate‐modified alginate (AlgMA) to enable ion‐induced reversible crosslinking that can dissipate energy under strain. The hybrid hydrogels provide a photocrosslinkable, injectable, and bioadhesive platform with an excellent toughness that can be tailored using divalent cations, such as calcium. This class of hybrid biopolymers with more than 600% improved toughness compared to GelMA may set the stage for durable, mechanically resilient, and cost‐effective tissue sealants. This strategy to increase the toughness of hydrogels may be extended to other crosslinkable polymers with similarly reactive moieties.

Journal

Advanced Healthcare MaterialsWiley

Published: May 1, 2020

Keywords: ; ; ; ; ;

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