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Evaluation of Clarithromycin Resistance in Helicobacter pylori Obtained from Culture Isolates, Gastric Juice, and Feces

Evaluation of Clarithromycin Resistance in Helicobacter pylori Obtained from Culture Isolates,... Dear Editor, The increase resistance of Helicobacter pylori to clarithromycin is worrisome because clarithromycin is often used to treat an H. pylori infection. We previously reported a highly sensitive non‐invasive method for the detection of clarithromycin‐resistant H. pylori in feces [ 1 ]. Alternatively, gastric juice has also been reported as a useful sample for the detection of clarithromycin‐resistant H. pylori [ 2,3 ]. Since the difference in the clarithromycin‐resistant H. pylori detection rates between sample types has not been sufficiently studied, we compared three samples, culture isolates, gastric juice, and feces for the detection of clarithromycin‐resistant H. pylori in this study. Fifty H. pylori ‐infected patients (24 males and 26 females; mean age 54.4 ± 15.2 years) who had visited Tokyo Medical University, Tokyo, Japan, between 2004 and 2008 were included in this study. Three types of samples, biopsy material, gastric juice, and feces, were obtained from each patient. Thirty‐one patients had no experience of the treatment for H. pylori eradication and the remaining 19 patients had failed to be treated by the regimen including clarithromycin. No antibiotic therapy was administered between the endoscopy and collection of the feces. H. pylori isolated from gastric biopsy material were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Helicobacter Wiley

Evaluation of Clarithromycin Resistance in Helicobacter pylori Obtained from Culture Isolates, Gastric Juice, and Feces

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References (6)

Publisher
Wiley
Copyright
© 2009 Blackwell Publishing Ltd
ISSN
1083-4389
eISSN
1523-5378
DOI
10.1111/j.1523-5378.2009.00663.x
pmid
19298344
Publisher site
See Article on Publisher Site

Abstract

Dear Editor, The increase resistance of Helicobacter pylori to clarithromycin is worrisome because clarithromycin is often used to treat an H. pylori infection. We previously reported a highly sensitive non‐invasive method for the detection of clarithromycin‐resistant H. pylori in feces [ 1 ]. Alternatively, gastric juice has also been reported as a useful sample for the detection of clarithromycin‐resistant H. pylori [ 2,3 ]. Since the difference in the clarithromycin‐resistant H. pylori detection rates between sample types has not been sufficiently studied, we compared three samples, culture isolates, gastric juice, and feces for the detection of clarithromycin‐resistant H. pylori in this study. Fifty H. pylori ‐infected patients (24 males and 26 females; mean age 54.4 ± 15.2 years) who had visited Tokyo Medical University, Tokyo, Japan, between 2004 and 2008 were included in this study. Three types of samples, biopsy material, gastric juice, and feces, were obtained from each patient. Thirty‐one patients had no experience of the treatment for H. pylori eradication and the remaining 19 patients had failed to be treated by the regimen including clarithromycin. No antibiotic therapy was administered between the endoscopy and collection of the feces. H. pylori isolated from gastric biopsy material were

Journal

HelicobacterWiley

Published: Apr 1, 2009

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