Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Exploring candidate gene associations with neuropsychological performance

Exploring candidate gene associations with neuropsychological performance We hypothesize that quantitative phenotypes related to Alzheimer's disease (AD), rather than the dichotomous disease phenotype, will increase the statistical power for identifying genetic risk factors. Neuropsychological test scores, which allow for the measurement of loss of cognitive function over time, are a particularly promising option for this approach. Using data from a cohort study of prodromal AD in 365 community‐recruited subjects with and without memory problems with a baseline and often one or more follow‐up administrations of a detailed neuropsychological test battery, we performed both cross‐sectional and longitudinal analyses using the known AD gene APOE and four other putative AD genes as predictors. APOE and a promoter polymorphism in insulin degrading enzyme (IDE_4U) showed evidence for association with cross‐sectional and longitudinal changes in memory (P = 0.016–0.025) and other cognitive functions. APOE and a polymorphism in the alpha‐2‐macroglobulin gene (A2M18i) also showed evidence for association with cross‐sectional and longitudinal changes in executive functioning (P = 0.010–0.042). In some cases, longitudinal analysis offered stronger evidence for association than could be seen cross‐sectionally. These preliminary results suggest that this approach has promised the development of a quantitative phenotype related to AD, but more elaborate methods will be required to address multiple comparisons issues in the setting of correlated data. © 2007 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics part B Wiley

Exploring candidate gene associations with neuropsychological performance

Download PDF
5 pages

Loading next page...
 
/lp/wiley/exploring-candidate-gene-associations-with-neuropsychological-XPnEvkgzTI

References (25)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley‐Liss, Inc., A Wiley Company
ISSN
1552-4841
eISSN
1552-485X
DOI
10.1002/ajmg.b.30500
pmid
17579348
Publisher site
See Article on Publisher Site

Abstract

We hypothesize that quantitative phenotypes related to Alzheimer's disease (AD), rather than the dichotomous disease phenotype, will increase the statistical power for identifying genetic risk factors. Neuropsychological test scores, which allow for the measurement of loss of cognitive function over time, are a particularly promising option for this approach. Using data from a cohort study of prodromal AD in 365 community‐recruited subjects with and without memory problems with a baseline and often one or more follow‐up administrations of a detailed neuropsychological test battery, we performed both cross‐sectional and longitudinal analyses using the known AD gene APOE and four other putative AD genes as predictors. APOE and a promoter polymorphism in insulin degrading enzyme (IDE_4U) showed evidence for association with cross‐sectional and longitudinal changes in memory (P = 0.016–0.025) and other cognitive functions. APOE and a polymorphism in the alpha‐2‐macroglobulin gene (A2M18i) also showed evidence for association with cross‐sectional and longitudinal changes in executive functioning (P = 0.010–0.042). In some cases, longitudinal analysis offered stronger evidence for association than could be seen cross‐sectionally. These preliminary results suggest that this approach has promised the development of a quantitative phenotype related to AD, but more elaborate methods will be required to address multiple comparisons issues in the setting of correlated data. © 2007 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics part B – Wiley

Published: Dec 5, 2007

Keywords: neuropsychological; genetic; longitudinal

There are no references for this article.