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Gastrointestinal lymphoma: where morphology meets molecular biology

Gastrointestinal lymphoma: where morphology meets molecular biology Primary gastrointestinal lymphomas are best exemplified by mucosa‐associated lymphoid tissue (MALT) lymphoma of the stomach and enteropathy‐type T‐cell lymphoma (ETL). Both lymphomas were initially recognized on morphological grounds and their identification as distinct clinicopathological entities has subsequently been vindicated following integrated immunophenotypic, molecular, and cellular biological investigations. Delineation of the phenotypic, molecular, and biological properties of these lymphomas at various clinicopathological stages of their development has also provided critical information for the clinical management of patients with these diseases. Here, the histopathology and recent advances in phenotypic and molecular characterization of gastric MALT lymphoma and ETL and their applications in diagnosis and clinical management are reviewed. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

Gastrointestinal lymphoma: where morphology meets molecular biology

The Journal of Pathology , Volume 205 (2) – Jan 1, 2005

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References (145)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services
ISSN
0022-3417
eISSN
1096-9896
DOI
10.1002/path.1703
pmid
15643667
Publisher site
See Article on Publisher Site

Abstract

Primary gastrointestinal lymphomas are best exemplified by mucosa‐associated lymphoid tissue (MALT) lymphoma of the stomach and enteropathy‐type T‐cell lymphoma (ETL). Both lymphomas were initially recognized on morphological grounds and their identification as distinct clinicopathological entities has subsequently been vindicated following integrated immunophenotypic, molecular, and cellular biological investigations. Delineation of the phenotypic, molecular, and biological properties of these lymphomas at various clinicopathological stages of their development has also provided critical information for the clinical management of patients with these diseases. Here, the histopathology and recent advances in phenotypic and molecular characterization of gastric MALT lymphoma and ETL and their applications in diagnosis and clinical management are reviewed. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Journal

The Journal of PathologyWiley

Published: Jan 1, 2005

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