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Genetics of tension‐type headache: A population based twin study

Genetics of tension‐type headache: A population based twin study The purpose was to investigate the importance of genetic and environmental factors in tension‐type headache using a genetic modeling analysis. Twins age 12–41 years old from the population based Danish Twin Registry received a validated posted questionnaire about tension‐type headache and migraine. Inclusion required that both twins in a pairs replied on the questionnaire and known zygosity. Twin pairs where one or both twins had co‐occurrence of migraine were excluded. Migraine significantly increases the risk as well as the frequency of tension–type headache. The quantitative genetic modeling included 2,437 monozygotic (MZ), 2,720 same gender dizygotic (DZ), and 2,203 opposite gender DZ twin pairs without co‐occurrence of migraine. Polychoric correlations were significantly higher in MZ than same gender DZ twin pairs analyzed separately by gender, while polychoric correlation were higher in same gender than opposite gender DZ twin pairs, although this was not significant in the comparison with male same gender DZ twin pairs. The best fitting model is based on gender specific prevalence and variance components without gender specific genetic effects. Heritability estimates of 48% in men and 44% in women were obtained. Genetic effects contribute to nearly half of variance in the liability to tension‐type headache. © 2007 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics part B Wiley

Genetics of tension‐type headache: A population based twin study

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References (33)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley‐Liss, Inc., A Wiley Company
ISSN
1552-4841
eISSN
1552-485X
DOI
10.1002/ajmg.b.30497
pmid
17853404
Publisher site
See Article on Publisher Site

Abstract

The purpose was to investigate the importance of genetic and environmental factors in tension‐type headache using a genetic modeling analysis. Twins age 12–41 years old from the population based Danish Twin Registry received a validated posted questionnaire about tension‐type headache and migraine. Inclusion required that both twins in a pairs replied on the questionnaire and known zygosity. Twin pairs where one or both twins had co‐occurrence of migraine were excluded. Migraine significantly increases the risk as well as the frequency of tension–type headache. The quantitative genetic modeling included 2,437 monozygotic (MZ), 2,720 same gender dizygotic (DZ), and 2,203 opposite gender DZ twin pairs without co‐occurrence of migraine. Polychoric correlations were significantly higher in MZ than same gender DZ twin pairs analyzed separately by gender, while polychoric correlation were higher in same gender than opposite gender DZ twin pairs, although this was not significant in the comparison with male same gender DZ twin pairs. The best fitting model is based on gender specific prevalence and variance components without gender specific genetic effects. Heritability estimates of 48% in men and 44% in women were obtained. Genetic effects contribute to nearly half of variance in the liability to tension‐type headache. © 2007 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics part B – Wiley

Published: Dec 5, 2007

Keywords: tension‐type headache; twin pairs; genetics; migraine

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