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Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate... Immune engIneerIng In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co-workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease-protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression. www.advancedscience.com http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Science Wiley

Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis (Adv. Sci. 11/2023)

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Publisher
Wiley
Copyright
© 2023 Wiley‐VCH GmbH
eISSN
2198-3844
DOI
10.1002/advs.202370064
Publisher site
See Article on Publisher Site

Abstract

Immune engIneerIng In article number 2202720, Nunzio Bottini, Nisarg J. Shah, and co-workers report the development of microparticles as a new potential therapy for autoimmune arthritis. When injected in inflamed joints, the microparticles slowly biodegrade and release an immunomodulatory agent that strengthens disease-protective immune cells. In mouse models of disease, the treatment approach protects joints from damage systemically while avoiding generalized immunosuppression. www.advancedscience.com

Journal

Advanced ScienceWiley

Published: Apr 1, 2023

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